beta 2-Microglobulin: structure, function and significance.

abstract：:Bivalent 7S subunits were obtained from 7 purified IgM human monoclonal anti-D antibodies with 33-63% of the total protein-retaining functional binding activity. The number of sites per red cell recognized by these subunits ranged between 9,400 and 28,500. The values are taken to indicate that a number of different ep...

journal_title：Vox sanguinis

authors： Hughes-Jones NC,Gorick BD,Beale D

更新日期：1990-01-01 00:00:00

abstract：:We have employed a PCR approach to determine the nucleotide sequences of the coding region in the last two coding exons of the histo-blood group ABO genes from one A(X) and one B(A) individual. Compared with A1 alleles, the (A(X)) allele has a single nucleotide substitution (T-->A at nucleotide 646) resulting in an am...

journal_title：Vox sanguinis

authors： Yamamoto F,McNeill PD,Yamamoto M,Hakomori S,Harris T

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The low-prevalence Rh antigen, JAL, was named after the index case, Mr. J. Allen. Based on reactivity of seven multi-specific sera with his RBCs, it was apparent that they express at least one additional low-prevalence antigen. The purpose of this study was to investigate the other low-prevalence antigen(s) ...

journal_title：Vox sanguinis

authors： Hue-Roye K,Reid ME,Westhoff CM,Lomas-Francis C

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To determine the frequency of maternal-fetal hemorrhage at or above 1 microliter of maternal whole blood. METHODS:Seventy-three mothers whose red blood cells bore an Rh antigen (Rh D, Rh c, Rh E) that was absent on red blood cells of their newborns were identified and a new cytological method, the Kleihauerimm...

journal_title：Vox sanguinis

authors： Brossard Y,Pons JC,Jrad I,van Nifterik J,Gillot R,Saure C,Le Gaudion M,Richard A,Papiernik E

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype agai...

journal_title：Vox sanguinis

authors： McGowan EC,Lopez GH,Knauth CM,Liew YW,Condon JA,Ramadi L,Parsons K,Turner EM,Flower RL,Hyland CA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In order to reduce the potential for transmission of hepatitis C virus (HCV) from an RNA-positive, anti-HCV-negative blood donation, the National Blood Service (NBS) introduced nucleic acid amplification technology (NAT) testing for HCV in England and Wales. The objective of this study was to ...

journal_title：Vox sanguinis

authors： Grant PR,Sims CM,Krieg-Schneider F,Love EM,Eglin R,Tedder RS

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Leucocyte-derived cytokines accumulate in stored whole blood. Pre-storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non-haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesize...

journal_title：Vox sanguinis

authors： Chudziak D,Sireis W,Pfeiffer HU,Henschler R,Seifried E,Bönig H

更新日期：2009-02-01 00:00:00

abstract：:Significantly more peripheral blood mononuclear cells (PBM) from 39 patients with lymphoma (p less than 0.001), myeloma (p less than 0.001), or leukemia (p less than 0.001-0.025) bind transferrin (Trf) than those of 23 normals. That Trf was bound to a receptor on these cells was shown by the inhibition of these cells ...

journal_title：Vox sanguinis

authors： Yeh CJ,Taylor CG,Faulk WP

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:Positive direct antiglobulin tests (DAT) occur occasionally, without obvious cause, among normal blood donors. This is sometimes associated with a false-positive serologic test for syphilis. Positive DATs due to antiphospholipid antibodies (APAbs) are well documented in the antiphospholipid syndrome with sys...

journal_title：Vox sanguinis

authors： Win N,Islam SI,Peterkin MA,Walker ID

更新日期：1997-01-01 00:00:00

abstract：:We developed a photodynamic method to inactivate viruses in human fresh plasma. Single plasma bags were illuminated with visible light in the presence of low doses of phenothiazine dyes like methylene blue or toluidine blue. By this treatment the infectivity of different enveloped viruses including the causative agent...

journal_title：Vox sanguinis

authors： Lambrecht B,Mohr H,Knüver-Hopf J,Schmitt H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transfusion of fresh-frozen plasma is still a pillar in emergency medicine for using to prevent dilutional coagulopathy or disseminated intravascular coagulation after severe blood loss, but thawing procedures can delay its availability. On the other hand, the wastage of plasma, once thawed an...

journal_title：Vox sanguinis

authors： Buchta C,Felfernig M,Höcker P,Macher M,Körmöczi GF,Quehenberger P,Heinzl H,Knöbl P

更新日期：2004-10-01 00:00:00

abstract：:Previously described methods of phenotyping red cells sensitised with IgG using the indirect antiglobulin test required the dissociation of the coating protein. Based on an entirely different principle, Fab fragments of anti-human IgG (Fab anti-IgG) were used to block the antiglobulin binding sites on cell-bound IgG m...

journal_title：Vox sanguinis

authors： Henry SM,Baird SJ,Woodfield DG

更新日期：1987-01-01 00:00:00

abstract：:Allelic subdeterminants (or splits) of the B12-Bw21 complex were characterized by the use of highly selected antisera and cell donors. The B12 antigen was separated into two major components, Bw44 and Bw45; and possibly a third. It was shown that Bw44 is primarily an antigen of whites, and Bw45 of blacks. Of the 68 pe...

journal_title：Vox sanguinis

authors： Mittal KK

更新日期：1980-01-01 00:00:00

abstract：:To determine what effect different preparative protocols and different platelet storage bags have on in vitro release, platelet concentrates were prepared according to two different protocols (group I: 2,200 g for 3.5 min followed by 4,900 g for 5 min; group II: 1,000 g for 9 min and 3,000 g for 20 min). The storage b...

journal_title：Vox sanguinis

authors： Snyder EL,Koerner TA Jr,Hezzey A

更新日期：1982-01-01 00:00:00

abstract：:The 2nd-generation anti-HCV test system was applied to a Saudi Arabian multi-ethnic donor population. When donors were stratified according to first-time donations versus repeat donations, the latter having been screened previously by a 1st-generation set of tests, it was found that in Saudi Arabian and Middle East na...

journal_title：Vox sanguinis

authors： Bernvil SS,Andrews VJ,Sasich F

更新日期：1994-01-01 00:00:00

abstract：:A method is described for the production of mouse monoclonal antibodies to HBsAg. 4 clones produced antibodies directed at the a and one at the d determinant of HBsAg. These antibodies were conjugated to horse radish peroxidase and used in an Elisa for the detection of HBsAg in donated blood. Antibody C10 produced con...

journal_title：Vox sanguinis

authors： Els MC,Govender M,Marimuthu T,Bubb MO,Conradie JD

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The absence of the red cell antigens P, P1 and Pk , known as 'p', represents an extremely rare red cell phenotype. Individuals with this phenotype spontaneously form anti-PP1Pk isoantibodies, associated with severe haemolytic transfusion reactions, recurrent spontaneous abortion and haemolytic disease of the...

journal_title：Vox sanguinis

authors： Di Ciaccio P,Cutts B,Alahakoon TI,Dennington PM,Soo LA,Curnow J

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Although most attention has been paid to viral infections as a complication of transfusion, some parasitic infections are readily transmissible and generate a heavy burden of disease, particularly in the developing world. Additionally, bacterial infection as a result of transfusion is the most...

journal_title：Vox sanguinis

authors： Dodd RY

更新日期：2000-01-01 00:00:00

abstract：:The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglyco...

journal_title：Vox sanguinis

authors： Daniels GL,Shaw MA,Judson PA,Reid ME,Anstee DJ,Colpitts P,Cornwall S,Moore BP,Lee S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The clinical significance of immune thrombocytopenia (ITP) is mainly reflected by bleeding and/or bleeding risks, which, in some cases, cannot be adequately controlled by standard therapy. Tranexamic acid (TA) is increasingly used in preventing and reducing bleeding in several medical settings...

journal_title：Vox sanguinis

authors： Mayer B,Salama A

更新日期：2017-11-01 00:00:00

abstract：:A selected group of women previously immunized in pregnancy by the Rh(D) antigen were boosted with 0.5 ml of Rh(D)-positive frozen recovered red cells from an accredited donor panel. The response was prompt and sustained and increased the anti-D content by almost 10-fold. In spite of the reduced rate of clinical immun...

journal_title：Vox sanguinis

authors： Gabra GS,Black M,Mitchell R

更新日期：1986-01-01 00:00:00

abstract：:As part of a programme to establish a panel of individuals with high titres of anticytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect haemagglutination assay, enzyme immunoassay, and complement fixation. The indirect haemagglutination assay ...

journal_title：Vox sanguinis

authors： Chung A,Chang W,Leung MK,Ofosu FA,Moore BP

更新日期：1984-01-01 00:00:00

abstract：:A panel of 50 blood group antibodies covering a range of blood group antigens has been tested in the presence of 0.25% beta-propiolactone as a possible means of reducing infectivity of high-risk HTLV III/HBsAg samples. 11/50 (22%) antibodies could not be detected by the indirect antiglobulin test, and 6/40 (15%) were ...

journal_title：Vox sanguinis

authors： Hunt AF,Jones MT,Howkins GJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma t...

journal_title：Vox sanguinis

authors： Karam O,Demaret P,Duhamel A,Shefler A,Spinella PC,Tucci M,Leteurtre S,Stanworth SJ,PlasmaTV investigators.

更新日期：2017-02-01 00:00:00

abstract：:The use of granulocyte transfusions in profoundly neutropenic patients has increased markedly in recent years. Whenever a pulmonary infiltrate develops during the course of these transfusions, the question arises as to what role the transfusions are playing and whether the transfusions should be discontinued to preven...

journal_title：Vox sanguinis

authors： Karp DD,Ervin TJ,Tuttle S,Gorgone BC,Lavin P,Yunis EJ

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In previous studies, we found that platelet microparticles (PMPs) bind to cord blood (CB) CD34+ cells and transfer adhesion molecules to them, which enhances their engraftment. Before applying this phenomenon in actual transplants, we investigated the effect of PMPs on cryopreserved CD34+ cell...

journal_title：Vox sanguinis

authors： Liu B,Chen JS,Cao M,Gu SL,Liao C,Li DZ,Zhong HZ

更新日期：2004-08-01 00:00:00

abstract：:Since its discovery, human plasminogen (PLG) polymorphism has received widespread acceptance in population genetics and forensic haematology. Due to the large number of variant alleles described, a PLG reference typing and Plasminogen Symposium was held, at which a nomenclature proposal was inaugurated. The technology...

journal_title：Vox sanguinis

authors： Skoda U,Bertrams J,Dykes D,Eiberg H,Hobart M,Hummel K,Kühnl P,Mauff G,Nakamura S,Nishimukai H

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:In Europe, buffy-coat processing allows for the use of platelet additive solutions (PAS). These solutions, however, have long been questioned for their lack of glucose, a potentially essential nutrient for platelet storage. Using a novel, practical, two-part system for incorporation of glucose into an additi...

journal_title：Vox sanguinis

authors： Gyongyossy-Issa MI,Zhang JG,Culibrk B,Hunter F,Levin E,Scammell K,Weiss S,Holmes DL,Holme S

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Red-blood-cells (RBCs) undergo structural and metabolic changes with prolonged storage, which ultimately may decrease their survival after transfusion. Although the storage-induced damage to RBCs has been rather well described biochemically, little is known about the mechanisms underlying the ...

journal_title：Vox sanguinis

authors： Hult A,Toss F,Malm C,Oldenborg PA

更新日期：2020-11-01 00:00:00

abstract：:To maximize the availability of platelet concentrates (PC) and minimize their outdate, competing criteria, a computer simulation model of platelet production and distribution was developed. Based on 2 years of actual platelet orders placed with a regional blood center, the simulation program generated daily platelet o...

journal_title：Vox sanguinis

authors： Katz AJ,Carter CW,Saxton P,Blutt J,Kakaiya RM

更新日期：1983-01-01 00:00:00