Abstract:
BACKGROUND:The absence of the red cell antigens P, P1 and Pk , known as 'p', represents an extremely rare red cell phenotype. Individuals with this phenotype spontaneously form anti-PP1Pk isoantibodies, associated with severe haemolytic transfusion reactions, recurrent spontaneous abortion and haemolytic disease of the fetus and newborn (HDFN). METHODS:We report a series of four successful pregnancies in three women with anti-PP1Pk isoantibodies, one complicated by HDFN, another by intrauterine growth restriction, all managed supportively. We also review the literature regarding the management of pregnancy involving anti-PP1Pk isoimmunization. RESULTS:The literature surrounding anti-PP1Pk in pregnancy is limited to a very small number of case reports. The majority report management with therapeutic plasma exchange (TPE) with or without intravenous immunoglobulin. The relationship between titre and risk of pregnancy loss remains unclear, though a history of recurrent pregnancy loss appears important. Although a positive cord blood direct antiglobulin test is frequently noted, clinically significant HDFN appears uncommon, though possible. CONCLUSION:Early initiation of TPE in high risk patients should be strongly considered. If possible, pregnancies should be managed in a high-risk obstetric or maternal fetal medicine service. The fetus should be monitored closely with interval fetal ultrasound and middle cerebral artery peak systolic volume Doppler to screen for fetal anaemia. Timely sourcing of compatible blood products is likely to be highly challenging, and both directed and autologous donation should be contemplated where appropriate. The International Red Cell Donor Panel may also provide access to compatible products.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Di Ciaccio P,Cutts B,Alahakoon TI,Dennington PM,Soo LA,Curnow Jdoi
10.1111/vox.13042subject
Has Abstractpub_date
2020-12-16 00:00:00eissn
0042-9007issn
1423-0410pub_type
杂志文章相关文献
VOX SANGUINIS文献大全abstract::Two preparations of fresh frozen plasma were studied. The plasma from CPDA-1 whole blood units was either frozen within 6 h (FFP-I) or 18-20 h (FFP-II) of phlebotomy. Average activity for factor VIII for FFP-I (n = 6) and FFP-II (n = 19) was 102% and 55%, respectively (p less than 0.01). Average activity for factor V ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1984.tb00046.x
更新日期:1984-01-01 00:00:00
abstract::The biochemical status of whole blood stored in containers fabricated of ethylene ethylacrylate (EEA) film was monitored at several times during 4 weeks of storage at 4 degrees C. Fifteen biochemical indicators were studied to reflect on erythrocyte integrity, cellular metabolism, plasma protein stability, and microag...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1985.tb00161.x
更新日期:1985-01-01 00:00:00
abstract::We report a preliminary study on whether syphilis serology might be reactive in some blood donors at risk for human immunodeficiency virus (HIV) infection. We retrospectively analyzed voluntary blood donations with reactive Treponema pallidum antibody (TPA) tests according to the type of donation, the presence of othe...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1991.tb00895.x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Individual genomic screening for viruses in blood donations is becoming increasingly pressing as an alternative to pool testing to improve the safety of the blood supply. MATERIALS AND METHODS:To determine the feasibility and, possibly, efficacy of genomic screening for hepatitis C virus (HCV...
journal_title:Vox sanguinis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000031041
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Severe anaemia is an important cause of mortality in developing countries. However, few studies have explored the use of and possibilities for blood transfusion services. The aims of this study are to explore the use of blood transfusion services at a hospital in sub-Saharan Africa and to asse...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2012.01628.x
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The platelet gel is made by embedding concentrate platelets within a semisolid (gel) network of polymerized fibrin. It is believed that this blood component will be used more and more in the treatment of several clinical conditions and as an adjunctive material in tissue engineering. Several systems are avai...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2007.01027.x
更新日期:2008-04-01 00:00:00
abstract::A competitive inhibition assay for functional fibronectin (Fn), based on ELISA technology, is described. The assay measures Fn's physiologic ability to bind to denatured collagen (gelatin). Affinity-purified Fn inhibits the binding of alkaline phosphatase coupled Fn to gelatin-coated wells of a microtiter plate in a c...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01910.x
更新日期:1983-01-01 00:00:00
abstract::A sandwich-type solid phase radioimmunoassay, FRC-RIA (Finnish Red Cross-RIA) for hepatitis B surface antigen (HBsAg) is described. Polystyrene test tubes coated with sheep anti-HBs gamma-globulin serve as the solid phase. The technique is specific and has a sensitivity of about 1 ng/ml for the subtypes ad and ay of H...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1978.tb02884.x
更新日期:1978-01-01 00:00:00
abstract::Blood transfusion practices have evolved empirically, with few or no research data supporting them. In the past several decades, fuelled by fears of infection and reports of mistakes, patients have increasingly demanded their rights to choice, both in the components given to them as well as to refuse to receive these ...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.1423-0410.2006.00867.x
更新日期:2007-02-01 00:00:00
abstract::The results obtained in a multicentre clinical trial of an enzyme immunoassay (EIA) method for hepatitis B surface antigen (HBsAg) (65,451 sera tested) have demonstrated that this new test has a significantly higher sensitivity than a reversed haemagglutination test (rHA). In a part of the trial, EIA was also compared...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1978.tb02902.x
更新日期:1978-07-01 00:00:00
abstract::Alanine aminotransferase (ALT), gamma-glutamyl-transferase and hepatitis B core antibodies were evaluated as donor markers in a prospective study of 685 open-heart surgery patients. Of these three surrogate markers, only an ALT level greater than or equal to 2 SD above the log mean had a significant association with r...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1991.tb00909.x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Since July 1 1999, four laboratories in the Netherlands have been routinely screening plasma minipools for the release of labile blood components utilizing hepatitis C virus nucleic acid amplification technology (HCV NAT). This report describes the performance evaluation of the HCV NAT method ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1046/j.1423-0410.2001.00055.x
更新日期:2001-07-01 00:00:00
abstract::Inhibitor development represents the main complication in the treatment of haemophilia A. The risk of inhibitor formation is in part genetically determined by the type of the underlying factor VIII gene lesion but environmental factors may also play an important role. Due to the lack of efficiency of factor VIII in th...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::Some effector functions of various immunoglobulin (IgG) preparations have been compared. Tests for opsonic activity were performed in vitro with human peripheral blood leukocytes and in vivo with mice. The augmentation effects on luminol-dependent chemiluminescence were investigated with human leukocytes. The compleme...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1986.tb01968.x
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Previous data that showed maintenance of reticulocyte percentage in whole blood stored in CPDA-1 have led to the assumption that reticulocyte maturation becomes arrested during refrigerated storage. However, reticulocyte behaviour in red-blood-cell units stored in additive solutions has not ye...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12011
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pr1,2,3, PrM, Sa and Sia-l1, -b1, -lb1 are sialic acid (NeuNAc)-dependent antigens recognized by human cold agglutinins. Pr and Sa antigens are the O-glycans of glycophorins containing alpha 2,3NeuNAc (to galactose) and/or alpha 2,6NeuNAc (to galactosamine). The antigens of the Sia-l1, -b1, -l...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Currently, plasma fractionation involves multiple processing steps using established methods such as ethanol precipitation and column chromatography. The known limitations associated with conventional purification techniques, combined with strict regulations on safety and high demand for parti...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1046/j.1423-0410.2002.00241.x
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is concern regarding the lack of prevention of unnecessary transfusion of RhD negative red cells and unnecessary administration of Rh immunoglobulin (RhIG) to pregnant women. In this study, performance of ID RHD XT, a genotyping assay for identification of six RHD allelic variants and hu...
journal_title:Vox sanguinis
pub_type: 杂志文章,多中心研究
doi:10.1111/vox.12886
更新日期:2020-04-01 00:00:00
abstract::A combined immunoassay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II (Bioelisa, Launch Diagnostics) has been evaluated to determine its suitability for routine use in blood screening. 84,222 donations were tested from 76,452 donors. One HIV- and 1 HTLV-1-positive donor were identified. The spec...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1995.tb02576.x
更新日期:1995-01-01 00:00:00
abstract::To elucidate the possible influence of previous blood transfusion on immune functions, the transfusion history of 153 patients admitted to hospital for elective colorectal surgery was correlated with lymphocyte subsets and natural killer (NK) cell function. The subsets determined were CD2, CD3, CD4, CD8, CD16, CD20, C...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1994.tb05035.x
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Red-blood-cell (RBC) transfusion is associated with lung injury, which is further exacerbated by mechanical ventilation. Manufacturing methods of blood products differ globally and may play a role in the induction of pulmonary cell activation through alteration of the immunomodulatory property...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12911
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Miltenberger subtype III (Mi.III, GP.Mur) is one of the most important red cell phenotypes in the fields of transfusion in South-East Asia. GP.Mur is believed to evolve from homologous gene recombination events between glycophorin A (GYPA) and glycophorin B (GYPB). GYP.Mur differs from GYPB in...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12236
更新日期:2015-05-01 00:00:00
abstract::Serum IgE was determined by radioimmunoassay in 28 subjects affected by homozygous beta thalassemia (14 males and 14 females, aged 3-19 years, mean age 7 +/- 5.6 years). They were given transfusions with packed red cells and chelant therapy. Blood samples were taken just before a transfusion (basal value) and at 10-da...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01931.x
更新日期:1983-01-01 00:00:00
abstract::A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1979.tb04390.x
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There are no randomized trials comparing intravenous iron to RBC transfusion for the treatment of severe postpartum anaemia. The objectives of this study were to evaluate the feasibility of randomizing women with severe postpartum anaemia secondary to postpartum haemorrhage to RBC transfusion ...
journal_title:Vox sanguinis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/vox.12475
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is increasing interest in the development of rapid and reliable techniques for human platelet alloantigen (HPA) typing. This study investigates the reliability of flow cytometry for large-scale immunophenotyping of platelet alloantigens. MATERIALS AND METHODS:We used flow cytometry and ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::An example of a cold-reacting IgM anti-K2 is described. The patient has a history of blood transfusion and two pregnancies. It is, therefore, not possible to differentiate between natural occurrence or immune stimulation as an explanation of this antibody's presence. In 1966, Thomas and Konugres reported an unusual ex...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1985.tb00189.x
更新日期:1985-01-01 00:00:00
abstract::Forty-six subjects (44 HIV antibody-positive) with some degree of immune deficiency (at least TH/TS ratio below 1) were randomly distributed into 4 treatment groups. Each group was assigned to 1 of 4 products to be used exclusively for a 1-year period: 1 concentrate was of intermediate purity and not heat-treated, and...
journal_title:Vox sanguinis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1423-0410.1987.tb04911.x
更新日期:1987-01-01 00:00:00
abstract::We performed a flow-cytometric analysis of the expression of D antigen in D+W samples (previously termed Du). We also analysed a series of D-positive and D-negative (cde phenotype) samples to obtain positive and negative controls, respectively. The evaluation was carried out by immunofluorescence and the intensity of ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1994.tb01278.x
更新日期:1994-01-01 00:00:00
abstract::The commercial immune serum globulin (ISG) product is suitable for use in passive immunization only by intramuscular administration; intravenous use results in vasomotor side reactions. We report the functional characterization of a chemically modified ISG (MISG) that is essentially free of nonspecific complement-bind...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1981.tb00726.x
更新日期:1981-01-01 00:00:00