Single-dose intravenous iron infusion versus red blood cell transfusion for the treatment of severe postpartum anaemia: a randomized controlled pilot study.

Abstract:

BACKGROUND AND OBJECTIVES:There are no randomized trials comparing intravenous iron to RBC transfusion for the treatment of severe postpartum anaemia. The objectives of this study were to evaluate the feasibility of randomizing women with severe postpartum anaemia secondary to postpartum haemorrhage to RBC transfusion or intravenous iron, and to describe patient-reported outcomes, and haematological and iron parameters. MATERIALS AND METHODS:Women with a postpartum haemorrhage exceeding 1000 ml and an Hb between 5·6 and 8·1 g/dl were randomized to 1500 mg of intravenous iron (n = 7) isomaltoside or RBC transfusion (n = 6). Participants completed the Multidimensional Fatigue Inventory and Edinburgh Postnatal Depression Scale, and blood samples were drawn at inclusion, daily during the first week and at weeks 3, 8 and 12. RESULTS:We screened 162 women and included 13 (8%). There was no significant difference between groups in fatigue or depression scores. RBC transfusion was associated with a higher Hb on day 1, inhibition of reticulocytosis during the first week and low iron levels. Intravenous iron was associated with increased reticulocytosis during the first week, repleted iron stores and a higher Hb in weeks 3-12. CONCLUSION:This pilot study shows that intravenous iron could be an attractive alternative to RBC transfusion in severe postpartum anaemia, and that a larger trial is needed and feasible.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Holm C,Thomsen LL,Norgaard A,Langhoff-Roos J

doi

10.1111/vox.12475

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

122-131

issue

2

eissn

0042-9007

issn

1423-0410

journal_volume

112

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00161.x

    authors: Horowitz B,Rowe AW,Stryker MH,Van der Sande J,Waldman AA,Wong SC,Gass JD,Woods KR

    更新日期:1985-01-01 00:00:00

  • Hemovigilance in the United States of America.

    abstract::Although hemovigilance is not a word used commonly in the United States, the concept of monitoring morbidity associated with blood transfusion is accepted widely. Currently, quality management focuses on error avoidance rather than error detection in both the "manufacturing" and "clinical" aspects of blood banking. "M...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05455.x

    authors: Menitove JE

    更新日期:1998-01-01 00:00:00

  • Plasmodium falciparum malaria and the immunogenetics of ABO, HLA, and CD36 (platelet glycoprotein IV).

    abstract::Plasmodium falciparum malaria has long been a killer of the young, and has selected for polymorphisms affecting not only erythrocytes, but the immunogenetics of three histocompatibility systems: ABO, human leukocyte antigen (HLA), and CD36. The ABO system is important because the original allele, encoding glycosylatio...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2010.01429.x

    authors: Cserti-Gazdewich CM,Mayr WR,Dzik WH

    更新日期:2011-01-01 00:00:00

  • Assessment of methods for cytomegalovirus antibody testing of blood donations.

    abstract::As part of a programme to establish a panel of individuals with high titres of anticytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect haemagglutination assay, enzyme immunoassay, and complement fixation. The indirect haemagglutination assay ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb04137.x

    authors: Chung A,Chang W,Leung MK,Ofosu FA,Moore BP

    更新日期:1984-01-01 00:00:00

  • Rapid thawing of fresh-frozen plasma with radio wave-based thawing technology and effects on coagulation factors during prolonged storage at 4 degrees C.

    abstract:BACKGROUND AND OBJECTIVES:With traditional techniques the thawing time for fresh-frozen plasma (FFP) is about 20-30 min. A new technology using radio waves, radio wave thawing device (RTD), was applied for thawing FFP. With this technology the thawing time can substantially be reduced. The new technique was compared to...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01175.x

    authors: Boström F,Ekemar L,Olsson D,Egberg N,Lundahl J

    更新日期:2009-07-01 00:00:00

  • The effect of plasmapheresis on blood pressure in voluntary plasma donors.

    abstract:BACKGROUND AND OBJECTIVES:Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of cellular components to the donor. Although plasma volume generally returns to normal, some residual effect on vital signs may be possible. This analysis was performed to determine the possible eff...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12188

    authors: Rosa-Bray M,Wisdom C,Marier JF,Mouksassi MS,Wada S

    更新日期:2015-01-01 00:00:00

  • Azapropazone-associated antibodies.

    abstract::2 patients on the drug azapropazone developed positive antiglobulin tests. Their sera were each found to contain two distinct antibodies. One was an IgG antibody, probably a drug-dependent autoantibody of the alpha-methyldopa type, but could have been related to the disease. The other was certainly a drug-dependent an...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00095.x

    authors: Bird GW,Wingham J,Babb RG,Bacon P,Wood D

    更新日期:1984-01-01 00:00:00

  • Monitoring bacterial contamination of blood components in Germany: effect of contamination reduction measures.

    abstract:BACKGROUND AND OBJECTIVES:National guidelines for monitoring bacterial contamination of blood components were introduced in Germany in 1997. Between 1998 and 2002, numerous measures were implemented to prevent bacterial contamination. This study investigates their impact on contamination rates. MATERIALS AND METHODS:C...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2010.01432.x

    authors: Walther-Wenke G,Wirsing von König CH,Däubener W,Heiden M,Hoch J,Hornei B,Volkers P,Working Party on Bacteria Safety in Transfusion Medicine, Advisory Board of the German Ministry of Health, Berlin.

    更新日期:2011-05-01 00:00:00

  • Selective depression of blood group antigens associated with hereditary ovalocytosis among melanesians.

    abstract::Recessively inherited ovalocytosis in coastal Melanesians is associated with widespread, but selective, depression of blood group antigens in homozygotes, who comprise about 15% of these populations. It is suggested that a membrane anomaly exists, and that the series of depressed determinants all depend, for their ful...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb00612.x

    authors: Booth PB,Serjeantson S,Woodfield DG,Amato D

    更新日期:1977-01-01 00:00:00

  • "VA", a new type of erythrocyte polyagglutination characterized by depressed H receptors and associated with hemolytic anemia. I. Serological and hematological observations.

    abstract::This report describes a case of persistent polyagglutinability restriced to the red blood cells, and associated with hemolytic anemia in a 20-year-old male. AIME WITH NORMAL INTERVALS. His red blood cells were weakly agglutinated by almost all adult sera. No autoagglutination was noted and the direct antihuman globuli...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Graninger W,Rameis H,Fischer K,Poschmann A,Bird GW,Wingham J,Neumann E

    更新日期:1977-01-01 00:00:00

  • A radial immunodiffusion method for the measurement of rat fibrinogen and fibrin degradation products.

    abstract::The present report describes a technique for the production of monospecific rabbit antiserum to rat fibrinogen and its use in a quantitative radial immunodiffusion assay for measurement of rat fibrinogen and fibrin degradation products. It is a suitable technique for measurement of these parameters in small samples wh...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04400.x

    authors: Kaplan JE,Blumenstock FA,Saba TM

    更新日期:1979-01-01 00:00:00

  • A family demonstrating inheritance of the Leach phenotype: a Gerbich-negative phenotype associated with elliptocytosis.

    abstract::The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglyco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb04860.x

    authors: Daniels GL,Shaw MA,Judson PA,Reid ME,Anstee DJ,Colpitts P,Cornwall S,Moore BP,Lee S

    更新日期:1986-01-01 00:00:00

  • A virally inactivated functional growth factor preparation from human platelet concentrates.

    abstract:BACKGROUND:Human platelet growth factors (HPGF) are essential for tissue regeneration and may replace fetal bovine serum (FBS) in cell therapy. No method for the manufacture of standardized virally inactivated HPGF has been developed yet. STUDY DESIGN AND METHODS:Platelet concentrates (PC) were subjected to solvent/de...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01180.x

    authors: Su CY,Kuo YP,Lin YC,Huang CT,Tseng YH,Burnouf T

    更新日期:2009-08-01 00:00:00

  • Standardization of CD62P measurement: results of an international comparative study.

    abstract:BACKGROUND AND OBJECTIVES:Despite long being a mainstay in describing platelet activation via degranulation, interlaboratory variation remains an issue in measurement of membrane CD62P by flow cytometry. Our objective was to identify actions that may minimize this variation. MATERIALS AND METHODS:Sixteen laboratories ...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/vox.12023

    authors: Levin E,Serrano K,Devine DV,Biomedical Excellence for Safer Transfusion (BEST) Collaborative.

    更新日期:2013-07-01 00:00:00

  • Inefficacy of plasma exchange in cold agglutinin hemolytic anemia--a case study.

    abstract::A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. In spite of considerable improvement of pertinent parameters (total IgM, cold agglutinin titer and thermal amplitude) this treatment failed to induc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00763.x

    authors: Rodenhuis S,Maas A,Hazenberg CA,Das PC,Nieweg HO

    更新日期:1985-01-01 00:00:00

  • Transfusion history, T cell subsets and natural killer cytotoxicity in patients with colorectal cancer.

    abstract::Blood transfusions are associated with clinical phenomena which are attributable to immune suppression. Since suppression of immune function is associated with a high risk of spontaneous malignancies, we studied T cell subsets and natural killer (NK) cytotoxicity in colorectal cancer patients and correlated the result...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb04954.x

    authors: Tartter PI,Steinberg B,Barron DM,Martinelli G

    更新日期:1989-01-01 00:00:00

  • Complement and biocompatibility.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05435.x

    authors: Mollnes TE

    更新日期:1998-01-01 00:00:00

  • Biofilm-associated accumulation-associated protein (Aap): A contributing factor to the predominant growth of Staphylococcus epidermidis in platelet concentrates.

    abstract:BACKGROUND AND OBJECTIVES:Staphylococcus epidermidis is a predominant contaminant of platelet concentrates (PCs), outcompeting other skin flora bacteria such as Staphylococcus capitis. The accumulation-associated protein (Aap), encoded by the aap gene, is involved in formation of bacterial aggregates (biofilms) in S. e...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12729

    authors: Alabdullatif M,Ramirez-Arcos S

    更新日期:2019-01-01 00:00:00

  • Method for processing leukocyte- and platelet-poor red cells in closed bags.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb04881.x

    authors: Shimizu T,Ishikawa Y,Tsurumi H,Hibi S,Takakura R,Morishima Y,Hasegawa I,Goto S

    更新日期:1986-01-01 00:00:00

  • Autoimmune hemolytic anemia associated with autoanti-Ge.

    abstract::The first reported example of autoimmune hemolytic anemia due to an autoanti-Gerbich is described. The patient's red blood cells exhibited a strongly positive direct antiglobulin test with both IgG and complement antiglobulin reagents. The serum contained a potent antibody which produced agglutination of red blood cel...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb01015.x

    authors: Reynolds MV,Vengelen-Tyler V,Morel PA

    更新日期:1981-01-01 00:00:00

  • Simultaneous occurrence of anti-F1 and anti-I cold agglutinins in a patient's serum.

    abstract::The second example of anti-F1 cold agglutinins recognizing a developmentally regulated antigen like I is described. The antibody occurred transiently and simultaneously together with an anti-I cold agglutinin. Although anti-F1 and anti-I specificities are entirely different, the data on the biochemistry of F1 and I an...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb01573.x

    authors: Roelcke D,Weber MT

    更新日期:1984-01-01 00:00:00

  • Molecular basis of red cell protein antigen deficiencies.

    abstract::Blood group antigens reside on cell surface molecules of wide structural and functional diversity. Although all are serologically detectable on red blood cells, most are also expressed in non erythroid tissues, but with a few exceptions their biological role on erythrocytes and tissues often remains elusive. Deficienc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:

    authors: Cartron JP

    更新日期:2000-01-01 00:00:00

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12148

    authors: Ramirez-Arcos S,Kou Y,Perkins H

    更新日期:2014-08-01 00:00:00

  • Pasteurisation of a factor I (C3b inactivator) concentrate from human plasma.

    abstract::A method of pasteurising a concentrate of factor I (C3b inactivator) prepared from human blood plasma is described. As well as obtaining a high yield of factor I by this virus inactivation procedure it is furthermore possible, by adjustment of the stabiliser concentration, to obtain a very pronounced reduction in the ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb00835.x

    authors: Alsøe KO,Kihl J

    更新日期:1989-01-01 00:00:00

  • Segregation of proteins and sodium in human plasma upon freezing.

    abstract::The proteins and sodium in human source blood plasma are segregated and concentrated on freezing, particularly in plasma that is frozen slowly in a large container. The temperature and the concentration gradients at the freezing front induce a convection in the liquid phase and thus play the primary role in the segreg...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01890.x

    authors: Chang CE

    更新日期:1983-01-01 00:00:00

  • Screening plasma donors for high-titre antibody to cytomegalovirus using a latex agglutination test.

    abstract::Cytomegalovirus (CMV) can cause severe morbidity in immunosuppressed patients. Regional transfusion centres in the UK are required to supply high-titre anti-CMV plasma to the Blood Products Laboratory (BPL), now called 'Bio-Products Laboratory', for the production of specific intravenous immunoglobulin at the Protein ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1990.tb05014.x

    authors: McDonald C,Barbara JA,al-Izzi A,Contreras M

    更新日期:1990-01-01 00:00:00

  • Biochemical studies on McLeod phenotype erythrocytes.

    abstract::Red cells of the McLeod phenotype in the Kell blood group system have an acanthocytic morphology. The membrane protein composition analyzed on sodium dodecyl-sulfate-polyacrylamide gel electrophoresis, the ATP level and the activities of a large number of intracellular enzymes appear to be normal. Membranes prepared f...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb00664.x

    authors: Tang LL,Redman CM,Williams D,Marsh WL

    更新日期:1981-01-01 00:00:00

  • Blood donations indeterminate in HIV-1 western blot analysed by IgM immunoblot and polymerase chain reaction.

    abstract::The presence of IgM antibodies to human immunodeficiency virus 1 (HIV-1) was investigated in blood donor sera which were indeterminate in anti-HIV-1 IgG Western blot testing. In 7 of 173 instances out of approximately 1,000,000 blood donation sera with an isolated anti-p24 IgG produced an anti-gp41-45 IgM immunoblot r...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb02524.x

    authors: Knüver-Hopf J,Heinze H,Lambrecht B,Mohr H,Beyer J,Schmitt H

    更新日期:1993-01-01 00:00:00

  • Study of the immunopotentiator effects of dialyzable leukocyte extracts obtained out of leukocytes previously used for interferon production.

    abstract::The existence of immunopotentiator factors able to induce blastogenesis, chemotaxis and able of inhibiting migration of leukocytes was investigated in alcohol precipitates of different batches of dialyzed leukocyte extracts (DLE). These were prepared either out of fresh leukocytes from a large pool of buffy coats obta...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb00018.x

    authors: Arala-Chaves MP,Porto MT,Kauppinen HL,Massa AA,Myllylä G

    更新日期:1982-11-01 00:00:00

  • Solvent/detergent treatment of human plasma--a very robust method for virus inactivation. Validated virus safety of OCTAPLAS.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05474.x

    authors: Biesert L,Suhartono H

    更新日期:1998-01-01 00:00:00