Purification of human immunoglobulin G: a new approach to plasma fractionation.

abstract：BACKGROUND:There exists only few data on in vitro and in vivo effects of gamma irradiation of leucoreduced red blood cells (RBCs). Reported studies reflect the effects of early irradiation and subsequent storage. The effects of irradiation on RBCs shortly before the end of their shelf-life have not been examined. STUD...

journal_title：Vox sanguinis

authors： Zimmermann R,Schoetz AM,Frisch A,Hauck B,Weiss D,Strobel J,Eckstein R

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This study was undertaken to provide denominator data relating to the timing and location of transfusion, to support interpretation of reports of incorrect blood component transfused (IBCT) events to the UK Serious Hazards of Transfusion (SHOT) scheme. MATERIALS AND METHODS:The study was carr...

journal_title：Vox sanguinis

authors： Tinegate HN,Thompson CL,Jones H,Stainsby D

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In order to reduce the potential for transmission of hepatitis C virus (HCV) from an RNA-positive, anti-HCV-negative blood donation, the National Blood Service (NBS) introduced nucleic acid amplification technology (NAT) testing for HCV in England and Wales. The objective of this study was to ...

journal_title：Vox sanguinis

authors： Grant PR,Sims CM,Krieg-Schneider F,Love EM,Eglin R,Tedder RS

更新日期：2002-05-01 00:00:00

abstract：:This report describes the recovery of highly purified immune-serum globulin (ISG) from the 42% ethanol precipitate fraction (42% P) generated during the first step of albumin purification. The method consists of three purification steps: (1) reprecipitation of the 42% P at 20% ethanol, pH 7.2; (2) solubilization of IS...

journal_title：Vox sanguinis

authors： Hao YL,Wickerhauser M

更新日期：1981-04-01 00:00:00

abstract：:2,140 pregnant Sudanese women attending the antenatal clinic in Omdurman Maternity Hospital during the period November 1975 to December 1976 had ABO and Rh typing performed. Their sera were also screened by a modified papain enzyme technique for the presence of atypical antibodies. The rate of Rhesus immunization, the...

journal_title：Vox sanguinis

authors： Abu-Sin AY,Ayoub M,Abdelrazig H

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Individual genomic screening for viruses in blood donations is becoming increasingly pressing as an alternative to pool testing to improve the safety of the blood supply. MATERIALS AND METHODS:To determine the feasibility and, possibly, efficacy of genomic screening for hepatitis C virus (HCV...

journal_title：Vox sanguinis

authors： Petrik J,Hewitt P,Barbara J,Allain J

更新日期：1999-01-01 00:00:00

abstract：:The effect on cryoprecipitate factor VIII recovery of three imortant variables has been investigated. The design of the study was such as to eliminate, for the purpose of internal comparisons, spurious effects such as those due to the variation in factor VIII levels in donor plasma. The choice of anticoagulant was sho...

journal_title：Vox sanguinis

authors： Wensley RT,Snape TJ

更新日期：1980-01-01 00:00:00

abstract：:Tissue oxygen delivery depends on red blood cell (RBC) content and RBC flow regulation in the microcirculation. The important role of the RBC in tissue oxygenation is clear from anaemia and the use of RBC transfusion which has saved many lives. Whether RBC transfusion actually restores tissue oxygenation is difficult ...

journal_title：Vox sanguinis

authors： Raat NJ,Ince C

更新日期：2007-07-01 00:00:00

abstract：:A panel of 50 blood group antibodies covering a range of blood group antigens has been tested in the presence of 0.25% beta-propiolactone as a possible means of reducing infectivity of high-risk HTLV III/HBsAg samples. 11/50 (22%) antibodies could not be detected by the indirect antiglobulin test, and 6/40 (15%) were ...

journal_title：Vox sanguinis

authors： Hunt AF,Jones MT,Howkins GJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Serologic tests for granulocyte antibodies, i.e., the granulocyte agglutination test and the granulocyte immunofluorescence test, require panels of typed granulocytes that cannot be preserved for more than a few hours. We have developed a new method in which granulocyte antigens, extracted int...

journal_title：Vox sanguinis

authors： Araki N,Nose Y,Kohsaki M,Mito H,Ito K

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Warm autoantibodies (WAA) are antibodies that react with an antigen on a patient's own red-blood-cells and can complicate compatibility testing whether or not they cause clinical haemolysis. The goal of this study was to understand the overall prevalence of WAA, the risk of RBC alloimmunization and determine...

journal_title：Vox sanguinis

authors： Delaney M,Apelseth TO,Bonet Bub C,Cohn CS,Dunbar NM,Mauro Kutner J,Murphy M,Perelman I,Selleng K,Staves J,Wendel S,Ziman A,Biomedical Excellence for Safer Transfusion (BEST) Collaborative.

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Host- or donor-derived alloimmune thrombocytopenia can develop after non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT). We report the first case of host-derived HPA-1a antibodies. CASE REPORT:A 52-year-old male patient received HSCT from his human leucocyte antigen ...

journal_title：Vox sanguinis

authors： Macher S,Schallmoser K,Staber PB,Neumeister P,Posch U,Lanzer G,Panzer S

更新日期：2005-11-01 00:00:00

abstract：:The 2nd-generation anti-HCV test system was applied to a Saudi Arabian multi-ethnic donor population. When donors were stratified according to first-time donations versus repeat donations, the latter having been screened previously by a 1st-generation set of tests, it was found that in Saudi Arabian and Middle East na...

journal_title：Vox sanguinis

authors： Bernvil SS,Andrews VJ,Sasich F

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Packed red blood cell transfusion has been associated with increased infection in a variety of critically ill patient populations. We evaluated the microbiology and time course of infection in transfused patients in the intensive care unit (ICU) as no data exist on these parameters. MATERIALS...

journal_title：Vox sanguinis

authors： Rachoin JS,Daher R,Schorr C,Milcarek B,Parrillo JE,Gerber DR

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Antibodies to the core of hepatitis B virus (anti-HBc) are considered to be the best serologically reliable markers of hepatitis B virus (HBV) infection. Through a national epidemiological survey, two young and first-time blood donors, originating from HBV-endemic areas, were identified as HBV...

journal_title：Vox sanguinis

authors： Laperche S,Guitton C,Smilovici W,Courouce AM

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Refractoriness to platelet transfusion because of HLA antibodies can jeopardize the outcome of patients who require platelet support during surgery. As routine screening for HLA antibodies would pose a huge burden on presurgical work-ups, a stratification of patients according to the risk of having HLA antib...

journal_title：Vox sanguinis

authors： Sanz C,Ghita G,Franquet C,Martínez I,Pereira A

更新日期：2010-10-01 00:00:00

abstract：:The risk of non-A, non-B hepatitis transmission by an intravenous immunoglobulin (IVIG) preparation was assessed in a prospective multicenter trial in 68 patients with primary immunodeficiency disorders (40 children or adolescents and 28 adults). During the 4-week prestudy evaluation period the clinical examinations a...

journal_title：Vox sanguinis

authors： Imbach P,Perret BA,Babington R,Kaminski K,Morell A,Heiniger HJ

更新日期：1991-01-01 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia (NAIT) is usually induced by platelet-specific antibodies against HPA-1a (Zwa) or HPA-5b (Bra). Recently, low-frequency alloantigens on the platelet glycoprotein (GP) IIb/IIIa complex have been discovered as a cause for NAIT. In this report, a new low-frequency platelet-specific al...

journal_title：Vox sanguinis

authors： Kiefel V,Vicariot M,Giovangrandi Y,Kroll H,Böhringer M,Greinacher A,Breitfeld C,Santoso S,Mueller-Eckhardt C

更新日期：1995-01-01 00:00:00

abstract：:A model of the Rh blood group system is proposed which is based on discontinuous gene structure. The R29 control subregion consists of a single exon flanked by introns. Following the R29 subregion, the R1 subregion exists as seven exon structures which alternate with introns. The expression of each exon is controlled ...

journal_title：Vox sanguinis

authors： Giorno R

更新日期：1981-01-01 00:00:00

abstract：:Although we still do not know enough about the influence of anaemia and transfusion on outcomes for the surgical patient, it is possible to develop a general consensus about many aspects of management. A quality programme to improve consistency of practice in these consensus areas is feasible. (Table 6) This should be...

journal_title：Vox sanguinis

authors： McClelland B

更新日期：1998-01-01 00:00:00

abstract：:A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in ...

journal_title：Vox sanguinis

authors： Verheugt FW,van Noord-Bokhorst JC,von dem Borne AE,Engelfriet CP

更新日期：1979-01-01 00:00:00

abstract：:In vivo immune phagocytosis of neonatal monocytes was significantly correlated to the extent of maternal HLA immunization. Monocytes from all 15 neonates of mothers with HLA antibodies show reduced immune phagocytosis. In contrast, this holds true for monocytes from only 6 out of 13 neonates of mothers without detecta...

journal_title：Vox sanguinis

authors： Neppert J,Mueller-Eckhardt G,Heine O

更新日期：1988-01-01 00:00:00

abstract：:beta 2-Microglobulin is a low molecular weight protein with sequence homology to immunoglobulins. As a portion of the HLA complex this protein is an important cell-surface structure. Under normal conditions beta 2-microglobulin is synthesized and shed by many cells, particularly lymphocytes, and is detectable in the c...

journal_title：Vox sanguinis

authors： Bernier GM

更新日期：1980-06-01 00:00:00

abstract：:Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-...

journal_title：Vox sanguinis

authors： Morell A,Schürch B,Ryser D,Hofer F,Skvaril F,Barandun S

更新日期：1980-01-01 00:00:00

abstract：:We report the development of a semi-continuous method for preparation of factor IX complex from human plasma using ion exchange resins. Traditionally, stirred batch adsorption has been used due to the high pressure drops and low flow rates associated with soft gels in packed columns. Batch methods, however, typically ...

journal_title：Vox sanguinis

authors： Tharakan JP,Gee DM,Clark DB

更新日期：1989-01-01 00:00:00

abstract：:Paraformaldehyde-fixed platelets from normal donors were used for detection of antibody to platelet by in vitro sensitization (indirect method) utilizing rabbit anti-human IgG heavy chain specific antibody-coated polyacrylamide gels (Immunobeads). The sensitized platelets formed rosettes with Immunobeads and the posit...

journal_title：Vox sanguinis

authors： Salmassi S,Yokoyama MM,Maples JA,Matsui Y

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Weak ABO variants may escape tests using unlicensed sera. MATERIALS AND METHODS:Prior to transfusion, ABO grouping was performed using an automated system and in-house diluted sera, and manual and bedside test techniques. Genotyping and sequencing were performed using standard methods. RESUL...

journal_title：Vox sanguinis

authors： Pruss A,Heymann GA,Braun J,Kiesewetter HH,Salama A

更新日期：2006-04-01 00:00:00

abstract：:A selected group of women previously immunized in pregnancy by the Rh(D) antigen were boosted with 0.5 ml of Rh(D)-positive frozen recovered red cells from an accredited donor panel. The response was prompt and sustained and increased the anti-D content by almost 10-fold. In spite of the reduced rate of clinical immun...

journal_title：Vox sanguinis

authors： Gabra GS,Black M,Mitchell R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:With traditional techniques the thawing time for fresh-frozen plasma (FFP) is about 20-30 min. A new technology using radio waves, radio wave thawing device (RTD), was applied for thawing FFP. With this technology the thawing time can substantially be reduced. The new technique was compared to...

journal_title：Vox sanguinis

authors： Boström F,Ekemar L,Olsson D,Egberg N,Lundahl J

更新日期：2009-07-01 00:00:00

abstract：:Pre- and posttransfusion antibody titers were performed on 6 patients with anti-Sda transfused with incompatible blood. In 3 of these patients a significant rise in IgG antibody titer was found. The data suggest that in occasional patients the Sda antigen does evoke a secondary immune response. We evaluated 245 pregna...

journal_title：Vox sanguinis

authors： Spitalnik S,Cox MT,Spennacchio J,Guenther R,Blumberg N

更新日期：1982-01-01 00:00:00