The effect of previous blood transfusion on lymphocyte subsets and natural killer cell function in patients with colorectal cancer.

Abstract:

:To elucidate the possible influence of previous blood transfusion on immune functions, the transfusion history of 153 patients admitted to hospital for elective colorectal surgery was correlated with lymphocyte subsets and natural killer (NK) cell function. The subsets determined were CD2, CD3, CD4, CD8, CD16, CD20, CD56, CD57 and HLA-DR-positive. The NK cell function was determined by measuring the killing capacity against cFDA-labelled K562 target cells monitored via a flow-cytometer. We found that 42 patients (27%) had been transfused before surgery, of these 13 had been transfused less than 30 days before surgery and 29 (19%) transfused more than 30 days before (median 10 years, range 0.1-37 years). In transfused patients, we found a significantly reduced number of B lymphocytes (CD20; p = 0.01), a reduction in HLA-DR-positive cells (p = 0.02) and a just significant reduction of NK cell function in transfused compared to nontransfused patients. The reduction in NK cell function is marginal and the NK cell function is within normal range, and probably without clinical significance. Reduction in NK cell function has been described before, whereas the reduction in B cells has not been reported earlier. The results may suggest an impaired humoral immunity and a minor reduction in cellular immunity in patients following blood transfusion.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Mathiesen O,Lund L,Brodthagen U,Gandrup P,Grunnet N,Balslev I,Jersild C

doi

10.1111/j.1423-0410.1994.tb05035.x

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

36-41

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

67

pub_type

杂志文章
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    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1159/000031079

    authors: Busch M,Chamberland M,Epstein J,Kleinman S,Khabbaz R,Nemo G

    更新日期:1999-01-01 00:00:00

  • Validation of the NucliSens Extractor in combination with the hepatitis C virus Cobas Amplicor 2.0 assay in four laboratories in the Netherlands utilizing nucleic acid amplification technology for blood screening.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2001.00055.x

    authors: Cuijpers HT,Molijn MH,Bos HJ,Peeters AP,van der Poel CL,Lelie PN

    更新日期:2001-07-01 00:00:00

  • Platelet concentrates. Influence of different preparative protocols on the in vitro release reaction.

    abstract::To determine what effect different preparative protocols and different platelet storage bags have on in vitro release, platelet concentrates were prepared according to two different protocols (group I: 2,200 g for 3.5 min followed by 4,900 g for 5 min; group II: 1,000 g for 9 min and 3,000 g for 20 min). The storage b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Snyder EL,Koerner TA Jr,Hezzey A

    更新日期:1982-01-01 00:00:00

  • Benefits and complications of regular blood transfusion in patients with beta-thalassaemia major.

    abstract::Early and regular blood transfusion therapy in patients with homozygous beta-thalassaemia decreases the complications of severe anaemia and prolongs survival. In the long term, however, the beneficial effects of transfusions are limited by the organ damage resulting from iron overload, a consequence of the body's limi...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1159/000031230

    authors: Prati D

    更新日期:2000-01-01 00:00:00

  • Single-dose intravenous iron infusion versus red blood cell transfusion for the treatment of severe postpartum anaemia: a randomized controlled pilot study.

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    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/vox.12475

    authors: Holm C,Thomsen LL,Norgaard A,Langhoff-Roos J

    更新日期:2017-02-01 00:00:00

  • Immunological monitoring of a patient with Guillain-Barré syndrome successfully treated with plasma exchange.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb01103.x

    authors: Fiorini G,Bigi G,Paracchini ML,Marinig C,Gibelli A

    更新日期:1982-01-01 00:00:00

  • A study of IgE in immunoglobulin preparations for intravenous administration. I. IgE in intravenous IgG.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb00220.x

    authors: Paganelli R,Quinti I,D'Offizi GP,Papetti C,Cabello A,Aiuti F

    更新日期:1986-01-01 00:00:00

  • Transmission of parasites and bacteria by blood components.

    abstract:BACKGROUND AND OBJECTIVES:Although most attention has been paid to viral infections as a complication of transfusion, some parasitic infections are readily transmissible and generate a heavy burden of disease, particularly in the developing world. Additionally, bacterial infection as a result of transfusion is the most...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:

    authors: Dodd RY

    更新日期:2000-01-01 00:00:00

  • Clinical consequences of the extremely rare anti-PP1Pk isoantibodies in pregnancy: a case series and review of the literature.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.13042

    authors: Di Ciaccio P,Cutts B,Alahakoon TI,Dennington PM,Soo LA,Curnow J

    更新日期:2020-12-16 00:00:00

  • Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00761.x

    authors: Goodrich RP,Li J,Pieters H,Crookes R,Roodt J,Heyns Adu P

    更新日期:2006-05-01 00:00:00

  • Red blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003-2016.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12775

    authors: Thorvaldsson HH,Vidarsson B,Sveinsdottir SV,Olafsson GB,Halldorsdottir AM

    更新日期:2019-07-01 00:00:00

  • Weak D alleles in Japanese: a c.960G>A silent mutation in exon 7 of the RHD gene that affects D expression.

    abstract:BACKGROUND AND OBJECTIVES:The molecular basis of the weak D phenotype has been investigated for many years, and more than 80 different alleles producing weak D phenotypes have been identified. Most alleles producing weak D phenotypes have a single missense mutation in exons corresponding to a transmembrane domain of th...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12322

    authors: Ogasawara K,Sasaki K,Isa K,Tsuneyama H,Uchikawa M,Satake M,Tadokoro K

    更新日期:2016-02-01 00:00:00

  • In vivo recovery and survival of red cells after photodynamic treatment with thiopyrylium and red light using a canine model.

    abstract::Recently, we have shown that thiopyrylium has robust inactivation capabilities against a broad spectrum of pathogens in the human red blood cell (RBC) suspensions while retaining key RBC in vitro properties. The 24-h recovery and survival of canine red cells were measured upon autologus reinfusion of control and photo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00864.x

    authors: Skripchenko A,Balch A,Mackin A,Wagner SJ

    更新日期:2007-02-01 00:00:00

  • Collection and use of stem cells; role of transfusion centers in bone marrow transplantation.

    abstract::Marrow transplantation is increasing, hematopoietic stem cells are being obtained from a wider variety of donors, and the cells almost always undergo some processing steps. These activities, along with the hematologic complexities of marrow transplant patients, create many varied opportunities for blood centers. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1994.tb04541.x

    authors: McCullough J

    更新日期:1994-01-01 00:00:00

  • Estimation of the infectious viral load required for transfusion-transmitted human T-lymphotropic virus type 1 infection (TT-HTLV-1) and of the effectiveness of leukocyte reduction in preventing TT-HTLV-1.

    abstract:BACKGROUND AND OBJECTIVES:The risk of transfusion-transmitted human T-lymphotropic virus type 1 infection (TT-HTLV-1) after prestorage leucocyte reduction (LR) remains unknown, as the proviral load in the blood component that would cause TT-HTLV-1 is undetermined. On the basis of the distribution of HTLV-1 proviral loa...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12263

    authors: Sobata R,Matsumoto C,Uchida S,Suzuki Y,Satake M,Tadokoro K

    更新日期:2015-08-01 00:00:00

  • Biochemistry of whole blood in poly(ethylene-co-ethylacrylate) experimental blood containers.

    abstract::The biochemical status of whole blood stored in containers fabricated of ethylene ethylacrylate (EEA) film was monitored at several times during 4 weeks of storage at 4 degrees C. Fifteen biochemical indicators were studied to reflect on erythrocyte integrity, cellular metabolism, plasma protein stability, and microag...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00161.x

    authors: Horowitz B,Rowe AW,Stryker MH,Van der Sande J,Waldman AA,Wong SC,Gass JD,Woods KR

    更新日期:1985-01-01 00:00:00

  • Biochemical, serological and family studies in individuals with Cis AB phenotypes.

    abstract::Pedigree studies and serological characterization of three cis AB families are presented. Serums of these persons exhibit strongly reduced activities of A gene-specified alpha-acetylgalactosaminyltransferase and only trace activities of B gene-dependent alpha-galactosyltransferase. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1975.tb00510.x

    authors: Pacuszka T,Kościelak J,Seyfried H,Walewska I

    更新日期:1975-01-01 00:00:00

  • Evaluation of a new microporous filtration membrane system for therapeutic plasma exchange.

    abstract::A new therapeutic plasma exchange device developed by Sarns Inc./3M was evaluated in plasmapheresis of 20 healthy volunteers and in a multicenter clinical study of therapeutic plasma exchange that included 49 patients. Safety and efficacy of plasma separation from whole blood were assessed for a module that contains D...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04925.x

    authors: Kurtz SR,Carey PM,McGill M,Pineda AA,Zaroulis CG,Case MT

    更新日期:1987-01-01 00:00:00

  • Clinical tolerance of methylene blue virus-inactivated plasma. A randomized crossover trial in 12 healthy human volunteers.

    abstract:OBJECTIVES:Baxter's methylene blue (MB) photoinactivation of fresh frozen plasma (FFP) is a method that effectively removes any intracellular potentially infectious agent, such as prions, by filtration combined with an improved photochemical virus inactivation on a single unit of FFP. The purpose of this study was to d...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000031129

    authors: Simonsen AC,Sørensen H

    更新日期:1999-01-01 00:00:00

  • Detection of a new weak A blood-group allele (Aw11).

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00752.x

    authors: Pruss A,Heymann GA,Braun J,Kiesewetter HH,Salama A

    更新日期:2006-04-01 00:00:00

  • Opsonic and complement-dependent bactericidal activities of various immunoglobulin preparations for intravenous use.

    abstract::Some effector functions of various immunoglobulin (IgG) preparations have been compared. Tests for opsonic activity were performed in vitro with human peripheral blood leukocytes and in vivo with mice. The augmentation effects on luminol-dependent chemiluminescence were investigated with human leukocytes. The compleme...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb01968.x

    authors: Yasuda H,Yajima T,Tanii T,Ashiba T,Iwata M

    更新日期:1986-01-01 00:00:00

  • Estimated risk of transmission of hepatitis C virus by blood transfusion.

    abstract:OBJECTIVE:The risk of transmitting hepatitis C (HCV) by transfusion of anti-HCV-negative screened blood was estimated for the blood donor population of Baden-Württemberg (southwestern Germany). METHODS:The data from the blood donors screened for anti-HCV and for HBsAg during 1990-1995 were analyzed. RESULTS:The preva...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Koerner K,Cardoso M,Dengler T,Kerowgan M,Kubanek B

    更新日期:1998-01-01 00:00:00

  • Influence of granulocyte antibodies on granulocyte function.

    abstract::The following substances were tested for their influence on granulocyte function: 8 sera that contained human granulocyte-specific alloantibodies against the antigens NA1, NA2 and NB1, two HLA antisera, and the monoclonal antibodies W6/32 and CLB-FcR-gran 1. The effects examined included spontaneous and directed migra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb03059.x

    authors: Bux J,Dickmann JO,Stockert U,Mueller-Eckhardt C

    更新日期:1993-01-01 00:00:00

  • A competitive inhibition assay for gelatin binding fibronectin.

    abstract::A competitive inhibition assay for functional fibronectin (Fn), based on ELISA technology, is described. The assay measures Fn's physiologic ability to bind to denatured collagen (gelatin). Affinity-purified Fn inhibits the binding of alkaline phosphatase coupled Fn to gelatin-coated wells of a microtiter plate in a c...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01910.x

    authors: Doran JE,Callaway BD,Reese AC,Wynn JJ,Mansberger AR

    更新日期:1983-01-01 00:00:00

  • Rapid thawing of fresh-frozen plasma with radio wave-based thawing technology and effects on coagulation factors during prolonged storage at 4 degrees C.

    abstract:BACKGROUND AND OBJECTIVES:With traditional techniques the thawing time for fresh-frozen plasma (FFP) is about 20-30 min. A new technology using radio waves, radio wave thawing device (RTD), was applied for thawing FFP. With this technology the thawing time can substantially be reduced. The new technique was compared to...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01175.x

    authors: Boström F,Ekemar L,Olsson D,Egberg N,Lundahl J

    更新日期:2009-07-01 00:00:00

  • An electronic method for counting human T and B cell rosettes.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb02298.x

    authors: Denny TN,Kinsley KM,Benson JW,Bull RW

    更新日期:1979-01-01 00:00:00

  • The ABCB6 mutation p.Arg192Trp is a recessive mutation causing the Lan- blood type.

    abstract:BACKGROUND AND OBJECTIVE:The membrane transporter ABCB6 has recently been shown to carry the high-frequency red-blood-cell (RBC) antigen Lan. All the Lan- individuals genotyped so far have inherited two recessive null mutations in ABCB6. The finding of a family with the Lan- blood type occurring in two successive gener...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2012.01650.x

    authors: Saison C,Helias V,Peyrard T,Merad L,Cartron JP,Arnaud L

    更新日期:2013-02-01 00:00:00

  • Use of segments for the quality control of the factor VIII: coagulant activity of fresh frozen plasma.

    abstract::The storage of fresh frozen plasma (FFP) for short periods at -20 degrees C for 6 weeks, -30 degrees C for 12 weeks, or -40 degrees C for 12 weeks, did not result in significant deterioration in factor VIII: coagulant (factor VIII:C) activity in the primary packs. In studies examining whether plasma segments could be ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00174.x

    authors: Ofosu FA,Blajchman MA,Kaegi A,Turc JM

    更新日期:1985-01-01 00:00:00

  • Blood transfusion in sickle cell disease.

    abstract::Blood transfusion is used as a life-saving and prophylactic treatment in sickle cell disease. Despite the many complications associated with its use, few randomised controlled trials and careful research studies have been performed to fully define its role. This subjects is, therefore, discussed in the context of the ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1995.tb03916.x

    authors: Davies SC,Olatunji PO

    更新日期:1995-01-01 00:00:00

  • Editorial: Red cell ageing and death.

    abstract::To obtain red cell populations of increasing mean age erythropoiesis was arrested through continuous actinomycin treatment or maintained transfusion polycythemia in mice and rats respectively. The parameters studied included cell indices, enzyme activities and rheological characteristics. Further, the life-span of age...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02809.x

    authors: Ganzoni AM,Barras JP,Marti HR

    更新日期:1976-01-01 00:00:00