Abstract:
:Auto-immune haemolytic anaemia (AIHA) has been found in a case of alpha-interferon treatment. Serum antibody and eluate were positive in the absence of the drug. Although the patient recovered after the treatment was stopped, DAGT remained positive for at least 8 months. The mechanism proposed to explain why this drug induced AIHA is similar to that proposed for alpha-methyl-dopa. Drugs could alter the red cell membrane and impair the immune system. Such changes have been observed with alpha-interferon and were related with increased autoimmunity.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Barbolla L,Paniagua C,Outeiriño J,Prieto E,Sánchez Fayos Jdoi
10.1111/j.1423-0410.1993.tb02135.xsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
156-7issue
2eissn
0042-9007issn
1423-0410journal_volume
65pub_type
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