In vivo behaviour of gamma globulin preparations.

Abstract:

:Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-GG from intramuscular deposits, its elimination from the intravascular compartment and from the body were studied in 2 probands. Metabolic properties of GG preparations for intravenous use were compared with those of St-GG in 3-4 probands after simultaneous injection of 125I- and 131I-labelled tracer doses. Important differences in the half-times of intravascular survival, in the rates of catabolism and in the distribution in the body were noticed for most of the preparations for intravenous use except for an improved acid-treated (pH 4) GG, the in vivo behaviour of which was similar to that of St-GG.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Morell A,Schürch B,Ryser D,Hofer F,Skvaril F,Barandun S

doi

10.1111/j.1423-0410.1980.tb02367.x

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

272-83

issue

5

eissn

0042-9007

issn

1423-0410

journal_volume

38

pub_type

杂志文章
  • Predicting massive blood transfusion using clinical scores post-trauma.

    abstract:BACKGROUND AND OBJECTIVES:Early prediction of massive transfusion (MT) post-trauma may reduce mortality by earlier delivery of blood products. A clinical prediction tool (PWH score) for this purpose was developed at the Prince of Wales Hospital, Hong Kong. The aims of this study were to apply this tool to major trauma ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2011.01564.x

    authors: Mitra B,Rainer TH,Cameron PA

    更新日期:2012-05-01 00:00:00

  • Technical aspects of the development and validation of tests for variant Creutzfeldt-Jakob disease in blood transfusion.

    abstract::The development of tests for variant Creutzfeldt-Jakob disease in the context of blood transfusion is technically complicated by a number of factors, including the long asymptomatic period and uncertainty as to whether infectivity is present in human blood at all. The specific needs of a donor test impose constraints....

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.0042-9007.2004.00411.x

    authors: Minor PD

    更新日期:2004-04-01 00:00:00

  • The low prevalence Rh antigen Be(a) (Rh36) is associated with RHCE*ce 662C>G in exon 5, which is predicted to encode Rhce 221Arg.

    abstract:BACKGROUND AND OBJECTIVES:The low prevalence antigen, Be(a), is produced by a complex that also produces weak c, e and f (ce). We report here the molecular basis associated with Be(a) antigen expression. MATERIALS AND METHODS:Peripheral blood samples from four Be(a+) probands were tested. Haemagglutination, gDNA extra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01277.x

    authors: Hue-Roye K,O'Shea K,Gillett R,Wadsworth LD,Hume H,Barnes J,Kinney J,Hodgins K,Fuchisawa A,Lomas-Francis C,Reid M

    更新日期:2010-04-01 00:00:00

  • Factors influencing plasma transfusion practices in paediatric intensive care units around the world.

    abstract:BACKGROUND AND OBJECTIVES:Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma t...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12490

    authors: Karam O,Demaret P,Duhamel A,Shefler A,Spinella PC,Tucci M,Leteurtre S,Stanworth SJ,PlasmaTV investigators.

    更新日期:2017-02-01 00:00:00

  • Splenic lymphoma presenting as warm autoimmune hemolytic anemia associated with pure red cell aplasia.

    abstract:BACKGROUND AND OBJECTIVE:Warm autoimmune hemolytic anemia (AIHA) is a condition in which peripheral red blood cell (RBC) destruction is induced by the presence of an autoantibody. Pure red cell aplasia (PRCA) represents an isolated process of decreased erythropoiesis. The combination of both is quite rare, with a very ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031163

    authors: Zeidman A,Fradin Z,Barac Y,Bendayan D,Mittelman M,Orlin J

    更新日期:2000-01-01 00:00:00

  • Estimation of the infectious viral load required for transfusion-transmitted human T-lymphotropic virus type 1 infection (TT-HTLV-1) and of the effectiveness of leukocyte reduction in preventing TT-HTLV-1.

    abstract:BACKGROUND AND OBJECTIVES:The risk of transfusion-transmitted human T-lymphotropic virus type 1 infection (TT-HTLV-1) after prestorage leucocyte reduction (LR) remains unknown, as the proviral load in the blood component that would cause TT-HTLV-1 is undetermined. On the basis of the distribution of HTLV-1 proviral loa...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12263

    authors: Sobata R,Matsumoto C,Uchida S,Suzuki Y,Satake M,Tadokoro K

    更新日期:2015-08-01 00:00:00

  • An analysis of autologous blood donor motivational factors.

    abstract::Little is known about the patient's reasons for participating in an autologous blood (AUB) collection program. We surveyed 110 AUB donors in our hospital-based collection program. Although fear of infection from an allogeneic blood transfusion was cited by 20% of AUB donors, 68.2% indicated that their physician's reco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb01679.x

    authors: Domen RE,Ribicki LA,Hoeltge GA

    更新日期:1995-01-01 00:00:00

  • Flow-cytometric method for the quantitation of the Fc function of intravenous immunoglobulin preparations.

    abstract:OBJECTIVES:We have developed and optimised a new flow-cytometric method for the measurement of the Fc function of intravenous immunoglobulin (IVIg) preparations, which is important in predicting the effector function of immunoglobulin (Ig) in such preparations. MATERIALS AND METHODS:Ig was bound to a monocytic cell li...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031178

    authors: Ramasamy I,Tran E,Charnock A,Farrugia A

    更新日期:2000-01-01 00:00:00

  • Separable anti-T and anti-Tk lectins from the seeds of Vicia hyrcanica.

    abstract::Separable anti-T and anti-Tk lectins can be extracted from the seeds of Vicia hyrcanica. The anti-T lectin is similar to that of the peanut, Arachis hypogaea; the anti-Tk lectin compares favourably with that of Griffonia simplicifolia II. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb03909.x

    authors: Liew YW,Bird GW

    更新日期:1988-01-01 00:00:00

  • Evaluation of HLA-haplotype disparate parental marrow grafts depleted of T lymphocytes by differential agglutination with a soybean lectin and E-rosette depletion for the treatment of severe combined immunodeficiency.

    abstract::The factors that impact upon successful bone marrow transplantation leading to immunologic reconstitution in severe combined immune deficiency (SCID). Wiskott-Aldrich syndrome, and in other lethal congenital immunodeficiencies are reviewed. Evidence is presented that graft-versus-host disease (GVHD) can be abrogated b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb02013.x

    authors: O'Reilly RJ,Brochstein J,Collins N,Keever C,Kapoor N,Kirkpatrick D,Kernan N,Dupont B,Burns J,Reisner Y

    更新日期:1986-01-01 00:00:00

  • Platelet storage media.

    abstract::Present platelet storage media often designated platelet additive solutions (PAS) basically contain acetate, citrate and phosphate and recently also potassium and magnesium. However, there seems to be an increasing interest in developing PASs that can be used also after further reduction of residual plasma content bel...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/vox.12172

    authors: Gulliksson H

    更新日期:2014-10-01 00:00:00

  • A Swiss family showing independent segregation of the Lutheran and Swann genes.

    abstract::A family is reported in which the parents' mating is of the 'double back-cross' type with respect to the Sw, Lu and Se genes. The inheritance of these genes in the children shows, with reference to a possible linkage between Sw and the two other loci, four non-recombinants and three recombinants (or vice versa). The i...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02221.x

    authors: Metaxas MN,Metaxas-Buehler M

    更新日期:1976-01-01 00:00:00

  • Method for processing leukocyte- and platelet-poor red cells in closed bags.

    abstract::If leukocyte- and platelet-poor red cells have been processed and stored in closed bags, their delivery, especially on holidays, will be easy. The modified warm-centrifuge method was applied to a quadruple bag prepared for such purpose. Red cells were processed in the first bag by the centrifugation of whole blood. Th...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb04881.x

    authors: Shimizu T,Ishikawa Y,Tsurumi H,Hibi S,Takakura R,Morishima Y,Hasegawa I,Goto S

    更新日期:1986-01-01 00:00:00

  • A new preparation of modified immune serum globulin (human) suitable for intravenous administration. II. Functional characterization.

    abstract::The commercial immune serum globulin (ISG) product is suitable for use in passive immunization only by intramuscular administration; intravenous use results in vasomotor side reactions. We report the functional characterization of a chemically modified ISG (MISG) that is essentially free of nonspecific complement-bind...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb00726.x

    authors: Schroeder DD,Tankersley DL,Lundblad JL

    更新日期:1981-01-01 00:00:00

  • Measuring clinical bleeding using a standardized daily report form and a computer algorithm for adjudication of WHO bleeding grades.

    abstract:INTRODUCTION:Bleeding is increasingly considered an important end point in clinical platelet transfusion studies. Accurate recording and adjudication into well-defined bleeding grades, however, remains a major challenge. METHODS:We developed a computer algorithm for automatic adjudication. The algorithm's results were...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/vox.12030

    authors: Middelburg RA,Ypma PF,van der Meer PF,van Wordragen-Vlaswinkel RJ,Eissen O,Kerkhoffs JL

    更新日期:2013-08-01 00:00:00

  • Preparation of human immunoglobulin free of plasmin and anticomplement activities.

    abstract::Human IgG separated by Cohn fractionation showed variability in the content of aggregates, plasminogen and anticomplement activity. The plasminogen was removed or markedly reduced by affinity chromatography on Sepharose-lysine. Anticomplement activity was reduced by chromatography of Cohn fraction II on DEAE-cellulose...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb00619.x

    authors: Habeeb AF,Francis RD

    更新日期:1977-01-01 00:00:00

  • Genetic control of immune responsiveness in man.

    abstract::Interest in immunogenetics originated from two streams: (a) histocompatibility in mouse and man, and (b) inheritance of specific immune responses in the guinea pig and mouse. In the mouse, there are genes associated with the major histocompatibility complex (MHC) which (i) code for antigens determining allograft respo...

    journal_title:Vox sanguinis

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1423-0410.1977.tb00598.x

    authors: Mackay IR,Wittingham S,Tait B

    更新日期:1977-01-01 00:00:00

  • Assessment of methods for cytomegalovirus antibody testing of blood donations.

    abstract::As part of a programme to establish a panel of individuals with high titres of anticytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect haemagglutination assay, enzyme immunoassay, and complement fixation. The indirect haemagglutination assay ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb04137.x

    authors: Chung A,Chang W,Leung MK,Ofosu FA,Moore BP

    更新日期:1984-01-01 00:00:00

  • HLA-DR: serology versus restriction fragment length polymorphism.

    abstract::The results of the serological typing and the patterns of restriction fragment length polymorphisms for the detection of HLA-DR gene products are compared. The data shown demonstrate that the use of DNA typing gives a clearer definition of the HLA-DR antigens and that the HLA-DR polymorphism is greater than detected b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00928.x

    authors: Nagy M,Mayr WR,Menzel GR

    更新日期:1991-01-01 00:00:00

  • Evaluation of the de-selection of men who have had sex with men from blood donation in England.

    abstract:BACKGROUND AND OBJECTIVES:The Blood Services of the UK permanently de-select men who have had sex with men (MSM) from donating blood. The rationale for this has been questioned. This article attempts to evaluate whether this selection criterion does contribute to blood safety. MATERIALS AND METHODS:Data about transfus...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2003.00295.x

    authors: Soldan K,Sinka K

    更新日期:2003-05-01 00:00:00

  • Haemolytic disease of the fetus and newborn.

    abstract::Haemolytic Disease of the Fetus and Newborn (HDFN) is caused by maternal alloimmunization against red blood cell antigens. In severe cases, HDFN may lead to fetal anaemia with a risk for fetal death and to severe forms of neonatal hyperbilirubinaemia with a risk for kernicterus. Most severe cases are caused by anti-D,...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/vox.12265

    authors: de Haas M,Thurik FF,Koelewijn JM,van der Schoot CE

    更新日期:2015-08-01 00:00:00

  • Monoclonal antibody recognizing a unique Rh-related specificity.

    abstract::A mouse IgG1 monoclonal antibody (MAb) UMRh, was prepared by immunizing Balb/c mice with the Jurkat T cell acute lymphoblastic leukemia (T-ALL) cell line. The MAb UMRh is directed against a widely distributed Rh-related cell surface antigen, present on red blood cells (RBCs) expressing the more common Rh phenotypes. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb03061.x

    authors: Poss MT,Swanson JL,Telen MJ,Lasky LC,Vallera DA

    更新日期:1993-01-01 00:00:00

  • Alanine aminotransferase, gamma-glutamyltransferase, antibodies to hepatitis B core antigen and antibodies to hepatitis C virus in blood donor screening. A prospective study in Finland.

    abstract::Alanine aminotransferase (ALT), gamma-glutamyl-transferase and hepatitis B core antibodies were evaluated as donor markers in a prospective study of 685 open-heart surgery patients. Of these three surrogate markers, only an ALT level greater than or equal to 2 SD above the log mean had a significant association with r...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00909.x

    authors: Ebeling F

    更新日期:1991-01-01 00:00:00

  • Use of segments for the quality control of the factor VIII: coagulant activity of fresh frozen plasma.

    abstract::The storage of fresh frozen plasma (FFP) for short periods at -20 degrees C for 6 weeks, -30 degrees C for 12 weeks, or -40 degrees C for 12 weeks, did not result in significant deterioration in factor VIII: coagulant (factor VIII:C) activity in the primary packs. In studies examining whether plasma segments could be ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00174.x

    authors: Ofosu FA,Blajchman MA,Kaegi A,Turc JM

    更新日期:1985-01-01 00:00:00

  • Factors associated with fainting: before, during and after whole blood donation.

    abstract::BACKGROUND  Whole blood (WB) donation encompasses several periods during which some donors faint. Identification of factors associated with fainting during each period should guide intervention strategies. Reducing faint reactions may reduce donor injuries and disability. METHODS  Blood donation was divided into three...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2011.01494.x

    authors: Bravo M,Kamel H,Custer B,Tomasulo P

    更新日期:2011-11-01 00:00:00

  • Resuscitation fluids.

    abstract:BACKGROUND AND OBJECTIVES:The aim of this review was to summarize the properties of the commonly available resuscitation fluids and highlight where knowledge of the characteristics of individual fluids might guide their use in clinical practice. Some of the current controversies surrounding resuscitation fluids are als...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1423-0410.2002.00123.x

    authors: Grocott MP,Hamilton MA

    更新日期:2002-01-01 00:00:00

  • International standards for minimum potency of anti-A and anti-B blood grouping reagents: evaluation of candidate preparations in an international collaborative study.

    abstract:BACKGROUND AND OBJECTIVES:The aim of the study was to evaluate lyophilized monoclonal IgM anti-A and anti-B preparations for use as international standards (IS) to specify recommended minimum potencies of anti-A and anti-B blood grouping reagents in tube tests. MATERIALS AND METHODS:The candidate IS for minimum potenc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00834.x

    authors: Thorpe SJ,Fox B,Heath AB,Scott M,de Haas M,Kochman S,Padilla A

    更新日期:2006-11-01 00:00:00

  • Lactated Ringer's solution versus hydroxyethyl starch for volume replacement in autologous blood donors with cardiovascular disease: a controlled, randomized trial.

    abstract:BACKGROUND AND OBJECTIVES:The study was designed to evaluate whether volume replacement following blood donation can prevent arterial hypotension in autologous blood donors with cardiovascular disease. MATERIALS AND METHODS:One hundred nineteen autologous blood donors with known cardiovascular disease were randomly al...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kasper SM,Dahlmann H,Mellinghoff H,Ellering J,Baumann M,Buzello W

    更新日期:1998-01-01 00:00:00

  • Donor selection in Japan: a trial of new criteria with predonation haemoglobin testing.

    abstract:BACKGROUND AND OBJECTIVES:In Japan, eligibility for blood donation depends on blood specific gravity, which does not directly measure blood haemoglobin. Additionally, the criteria are not based on normal values. Therefore, we investigated the feasibility of predonation screening by using actual haemoglobin levels, and ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.0042-9007.2001.00145.x

    authors: Shimoyama R,Nakase T,Kojima S,Tanaka S,Yamamori K,Kaneko C,Ishimaru K,Ikeda H

    更新日期:2002-02-01 00:00:00

  • Collaborative study to calibrate hepatitis C virus genotypes 2-6 against the HCV International Standard, 96/790 (genotype 1).

    abstract:BACKGROUND AND OBJECTIVES:A major requirement of a hepatitis C virus (HCV) RNA nucleic acid amplification technology (NAT) assay validation is the ability of the assay to detect the six major genotypes of HCV with equivalent sensitivities. The aim of this study was to characterize and calibrate an HCV genotype panel fo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2003.00260.x

    authors: Saldanha J,Heath A,Collaborative Study Group.

    更新日期:2003-01-01 00:00:00