Abstract:
:Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-associated mortality. The inadvertent transfusion of neutrophil antibodies can cause pulmonary transfusion reactions and TRALI. However, not all patients transfused with neutrophil antibodies experience transfusion reactions. A 22-year-old man with severe aplastic anaemia (SAA) experienced TRALI after a platelet transfusion. The donor was found to be alloimmunized to human neutrophil antigen (HNA)-3a, an antigen expressed by neutrophils from approximately 90% of Caucasians. Eleven other platelet components from this donor were transfused prior to this event and two caused reactions: one chills and one TRALI. Both episodes of TRALI occurred in the same male patient with SAA. The fact that one patient experienced TRALI following both exposures to anti-HNA-3a from the same donor whereas nine other recipients did not adds evidence to the observation that patient factors make a significant contribution to neutrophil antibody-mediated transfusion reactions.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Muniz M,Sheldon S,Schuller RM,Young NS,Klein HG,Leitman SF,Stroncek DFdoi
10.1111/j.1423-0410.2007.00982.xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
70-3issue
1eissn
0042-9007issn
1423-0410pii
VOX982journal_volume
94pub_type
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