Transfusion practice in massively bleeding patients: time for a change?

Abstract:

BACKGROUND AND OBJECTIVES:We identified some fatal cases where massively bleeding patients received inadequate transfusion therapy. The aim of this study was to review and evaluate the transfusion practice in acutely multitransfused patients. MATERIALS AND METHODS:Patients receiving > 10 units of red blood cells (RBC) within 24 h of admission and 30 blood components within 7 days of admission were reviewed. RESULTS:Thirty-nine patients were identified, 13 of whom were inadequately transfused (IT) and had a higher mortality (12/13) than adequately transfused (AT) patients 13/26 (P = 0.013). Ten of 13 IT patients developed a microvascular bleed compared to four of 26 in the AT group (P = 0.001) and had a lower platelet count upon arrival at the intensive care unit (40 x 10(9)/l vs. 80 x 10(9)/l, P = 0.024). CONCLUSIONS:An early balanced transfusion therapy is vital in massively bleeding patients, and a pro-active approach from the blood bank is warranted. We have introduced an acute transfusion package (ATP) consisting of 5 RBC, 5 FFP and 2 PC units, indicated in massively bleeding patients, securing a balanced transfusion therapy.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Johansson PI,Hansen MB,Sørensen H

doi

10.1111/j.1423-0410.2005.00668.x

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

92-6

issue

2

eissn

0042-9007

issn

1423-0410

pii

VOX668

journal_volume

89

pub_type

杂志文章
  • Acute hypoproteinemic fluid overload: its determinants, distribution, and treatment with concentrated albumin and diuretics.

    abstract::We simulated the use of massive volumes of crystalloid fluids as a treatment of acute plasma loss in a standardized experimental model and studied the factors determining the retention or excretion of the resulting acute hypoproteinemic fluid overload, its distribution within the body, and its treatment with concentra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb04481.x

    authors: Pappova E,Bachmeier W,Crevoisier JL,Kollar J,Kollar M,Tobler P,Zahler HW,Zaugg D,Lundsgaard-Hansen P

    更新日期:1977-01-01 00:00:00

  • The D antigen characteristic of RoHar is a partial D antigen.

    abstract::The results of testing RoHarr cells with panels of monoclonal anti-D suggest that the D antigen (referred to as DHar) encoded by the haplotype (D)c(e) Rh33 is a partial D antigen. IgM monoclonal anti-D are more efficient than IgG monoclonal anti-D in detecting DHar.DHar expresses some but not all of both epD5 and epD6...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1996.tb01317.x

    authors: Wallace M,Lomas-Francis C,Tippett P

    更新日期:1996-01-01 00:00:00

  • Relevance of flow cytometric enumeration of post-thaw leucocytes: influence of temperature during cell staining on viable cell recovery.

    abstract:BACKGROUND AND OBJECTIVES:Our post-thaw cell recovery rates differed substantially in interlaboratory comparisons of identical samples, potentially due to different temperatures during cell staining. MATERIALS AND METHODS:Viable CD34(+) cells and leucocyte (WBC) subtypes were quantified by multiparameter single-platfo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12398

    authors: Fritsch G,Frank N,Dmytrus J,Frech C,Pichler H,Witt V,Geyeregger R,Scharner D,Trbojevic D,Zipperer E,Printz D,Worel N

    更新日期:2016-08-01 00:00:00

  • De novo protein synthesis in mature platelets: a consideration for transfusion medicine.

    abstract::Platelet function in thrombosis and haemostasis is reasonably well understood at the molecular level with respect to the proteins involved in cellular structure, signalling networks and platelet interaction with clotting factors and other cells. However, the natural history of these proteins has only recently garnered...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2010.01333.x

    authors: Schubert P,Devine DV

    更新日期:2010-08-01 00:00:00

  • A simplified method for the preparation of immune-serum globulin.

    abstract::This report describes the recovery of highly purified immune-serum globulin (ISG) from the 42% ethanol precipitate fraction (42% P) generated during the first step of albumin purification. The method consists of three purification steps: (1) reprecipitation of the 42% P at 20% ethanol, pH 7.2; (2) solubilization of IS...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb00706.x

    authors: Hao YL,Wickerhauser M

    更新日期:1981-04-01 00:00:00

  • The ABCB6 mutation p.Arg192Trp is a recessive mutation causing the Lan- blood type.

    abstract:BACKGROUND AND OBJECTIVE:The membrane transporter ABCB6 has recently been shown to carry the high-frequency red-blood-cell (RBC) antigen Lan. All the Lan- individuals genotyped so far have inherited two recessive null mutations in ABCB6. The finding of a family with the Lan- blood type occurring in two successive gener...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2012.01650.x

    authors: Saison C,Helias V,Peyrard T,Merad L,Cartron JP,Arnaud L

    更新日期:2013-02-01 00:00:00

  • Anti-A production by a group O spleen transplanted to a group A recipient.

    abstract::A group A1 diabetic received a pancreas-spleen transplant from a group 0 donor. Severe immune hemolysis due to anti-A ensued, requiring graft splenectomy. The transplanted spleen can be a potent source of blood group antibody. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00187.x

    authors: Salamon DJ,Ramsey G,Nusbacher J,Yang S,Starzl TE,Israel L

    更新日期:1985-01-01 00:00:00

  • pH, temperature and lactate production in human red blood cells: implications for blood storage and glycolytic control.

    abstract::The interaction of temperature and pH in biological systems comprises two components. Temperature change may perturb the pH of solutions, and it may change the pKa of some ionizable groups that are involved in enzyme catalysis. The pH optima of single reactions and whole pathways are therefore temperature sensitive. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1992.tb01173.x

    authors: Guppy M,Attwood PV,Hansen IA,Sabaratnam R,Frisina J,Whisson ME

    更新日期:1992-01-01 00:00:00

  • Autoantibodies in HIV-infected hemophilia patients against different epitopes on CD4+ lymphocytes and recombinant CD4.

    abstract::We studied 684 sera obtained from 20 hemophilia patients with AIDS/AIDS-related complex (ARC), 89 asymptomatic HIV+, 76 HIV- hemophilia patients and 151 healthy controls for antibodies against recombinant CD4 (rCD4). Twenty-two percent of AIDS/ARC patients, 10% of asymptomatic HIV+ patients, 17% of HIV-patients, and 1...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1992.tb01165.x

    authors: Daniel V,Weimer R,Zettlmeissl G,Langner K,Zimmermann R,Opelz G

    更新日期:1992-01-01 00:00:00

  • Intrapatient comparison of an intermittent and a continuous flow cell separator for the collection of progenitor and stem cells from the blood.

    abstract:BACKGROUND AND OBJECTIVES:Continuous-flow and intermittent-flow blood cell separators (CFCS and IFCS) are both used to collect stem cells from the blood to rescue patients undergoing myeloablative treatment for cancer. MATERIALS AND METHODS:We designed a study to compare the collection efficiency of the two systems. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Beretta F,van den Bosch S,Castelli D,Cavalli F,Ghielmini M

    更新日期:1998-01-01 00:00:00

  • Supernatants of stored polymorphonuclear neutrophils exhibit growth-promoting activity in several cell lines: perforin expression in polymorphonuclear neutrophils and its role in down-regulation of growth-promoting activity.

    abstract:BACKGROUND AND OBJECTIVES:Polymorphonuclear neutrophils (PMNs) play important roles in the host immune defence. This study was performed to identify roles of PMNs other than those already known. MATERIALS AND METHODS:PMNs were separated from the peripheral blood of healthy individuals and stored in vitro for 24 h in t...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00156.x

    authors: Nishimura M,Mitsunaga S,Juji T

    更新日期:2002-04-01 00:00:00

  • A 'new' allele, Kpc, at the Kell complex locus.

    abstract::Four Kp(a-b-) Japanese sisters, the product of a consanguineous mating, have otherwise normal Kell antigens. Kpc, a 'new' allele of Kpa and Kpb is the most probable background. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04395.x

    authors: Yamaguchi H,Okubo Y,Seno T,Matsushita K,Daniels GL

    更新日期:1979-01-01 00:00:00

  • Activity of B-gene-specified galactosyltransferase in individuals with Bm phenotypes.

    abstract::Blood group B-gene-specified alpha-galactosyltransferase was determined in serums and erythrocyte membranes of several related persons with Bm phenotypes. The level of this enzyme in serums was similar to, but in erythrocyte membranes much lower than that found in normal B and AB persons. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb04834.x

    authors: Kościelak J,Pacuszka T,Dzierzkowa-Borodej W

    更新日期:1976-01-01 00:00:00

  • Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation.

    abstract:BACKGROUND AND OBJECTIVES:Red-blood-cell (RBC) transfusion is associated with lung injury, which is further exacerbated by mechanical ventilation. Manufacturing methods of blood products differ globally and may play a role in the induction of pulmonary cell activation through alteration of the immunomodulatory property...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12911

    authors: Wirtz MR,Almizraq RJ,Weber NC,Norris PJ,Pandey S,Spinella PC,Muszynski JA,P Acker J,Juffermans NP

    更新日期:2020-07-01 00:00:00

  • A new method to collect granulocytes using a low dose of hydroxyethyl starch.

    abstract::A new granulocyte collection method employing discontinuous flow centrifugation and low donor dose of hydroxyethyl starch (HES) is presented. Following the procedure, the increase in serum polysaccharide concentration was 100 mg/dl, about 20% of that seen after standard discontinuous flow leukapheresis. The average ef...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb04111.x

    authors: Szymanski IO

    更新日期:1983-01-01 00:00:00

  • Photoinactivation of Leishmania donovani infantum in red cell suspensions by a flexible thiopyrylium sensitizer.

    abstract:BACKGROUND AND OBJECTIVES:Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, which are intracellular parasites of monocytes and macrophages. Transmission of the organism has been observed by transfusion of infected blood from asymptomatic donors to immunocompromised recipients, leading to...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00810.x

    authors: Wagner SJ,Skripchenko A,Salata J,Cardo LJ

    更新日期:2006-08-01 00:00:00

  • Maximising platelet availability by delaying cold storage.

    abstract:BACKGROUND AND OBJECTIVES:Cold-stored platelets may be an alternative to conventional room temperature (RT) storage. However, cold-stored platelets are cleared more rapidly from circulation, reducing their suitability for prophylactic transfusion. To minimise wastage, it may be beneficial to store platelets conventiona...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12649

    authors: Wood B,Johnson L,Hyland RA,Marks DC

    更新日期:2018-04-06 00:00:00

  • Comparison of three commercially available buffy coat pooling sets for the preparation of platelet concentrates.

    abstract:BACKGROUND:A disposable set for platelet concentrate (PC) preparation by the buffy coat method allows pooling of buffy coats, centrifugation and cell separation with in-line leucocyte filtration. This study compares three commercially available pooling sets in combination with INTERCEPT pathogen inactivation (PI). MAT...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12668

    authors: Feys HB,Devloo R,Sabot B,Coene J,Compernolle V

    更新日期:2018-05-24 00:00:00

  • The influence of ionic strength and incubation time on the sensitivity of methods using papainized red cells.

    abstract::The sensitivity of a combination of various papain methods with normal and low ionic strength (lis) of the serum-cell mixture for the detection of red cell antibodies was tested after varying periods of incubation of the mixture. The mixture was centrifuged before reading when the period of incubation was short. The m...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb02280.x

    authors: Jørgensen J,Nielsen M,Laugesen J,Stoltenberg S

    更新日期:1979-01-01 00:00:00

  • Severe thrombocytopenia due to host-derived anti-HPA-1a after non-myeloablative allogeneic haematopoietic stem cell transplantation for multiple myeloma: a case report.

    abstract:BACKGROUND AND OBJECTIVES:Host- or donor-derived alloimmune thrombocytopenia can develop after non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT). We report the first case of host-derived HPA-1a antibodies. CASE REPORT:A 52-year-old male patient received HSCT from his human leucocyte antigen ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2005.00692.x

    authors: Macher S,Schallmoser K,Staber PB,Neumeister P,Posch U,Lanzer G,Panzer S

    更新日期:2005-11-01 00:00:00

  • An analysis of autologous blood donor motivational factors.

    abstract::Little is known about the patient's reasons for participating in an autologous blood (AUB) collection program. We surveyed 110 AUB donors in our hospital-based collection program. Although fear of infection from an allogeneic blood transfusion was cited by 20% of AUB donors, 68.2% indicated that their physician's reco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb01679.x

    authors: Domen RE,Ribicki LA,Hoeltge GA

    更新日期:1995-01-01 00:00:00

  • Blood group ABH antigens on human cord red cells. Number of H antigenic sites and their distribution among different classes of membrane constituents.

    abstract::When the blood group H sites of cord erythrocytes obtained from newborn infants of groups O, A, B and AB were labelled specifically by incubation of the whole cells with the A1 gene dependent alpha-N-acetylgalactosaminyl transferase in the presence of UDP-N-acetyl [14C]-galactosamine, the incorporation of radioactivit...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1980.tb04497.x

    authors: Schenkel-Brunner H

    更新日期:1980-06-01 00:00:00

  • Legal, financial, and public health consequences of transfusion-transmitted hepatitis C virus in persons with haemophilia.

    abstract:BACKGROUND:Since the first cases of acquired immunodeficiency syndrome in persons with haemophilia were reported in 1982, much has been written about the consequences of human immunodeficiency virus (HIV) contamination of the blood supply. Relatively little attention has been paid to similar hepatitis C virus (HCV) con...

    journal_title:Vox sanguinis

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1423-0410.2007.00941.x

    authors: Angelotta C,McKoy JM,Fisher MJ,Buffie CG,Barfi K,Ramsey G,Frohlich L,Bennett CL

    更新日期:2007-08-01 00:00:00

  • Expression of genetic markers of erythrocyte immunoglobulin G autoantibodies in autoimmune hemolytic anemia.

    abstract::The Gm allotype constitution of the autoantibody molecules and the serum Gm phenotypes were determined in 19 patients with autiommune hemolytic anemia of IgG type. The results showed that the known heterogeneity of the antierythrocyte autoantibodies in this disease concerns not only the immunoglobulin class and the is...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02208.x

    authors: Le Petit JC,Rivat L,François N,Ropartz C,Brizard CP

    更新日期:1976-01-01 00:00:00

  • The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.

    abstract::With regard to hemostasis and thrombosis, collagens are among the most important physiologic components of the extracellular matrix in their role as platelet activators. Differences in the rate of platelet activation markedly influence normal hemostasis and the pathological outcome of thrombosis. Thus, collagen recept...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2002.tb05274.x

    authors: Kunicki TJ,Nugent DJ

    更新日期:2002-08-01 00:00:00

  • Improvement of enzyme-linked antiglobulin test by using an antiglobulin linked to glucose oxidase: description of the technique.

    abstract::The classic enzyme-linked antiglobulin test (ELAT) used to detect and quantify the amount of IgG antibodies on red blood cells (RBC) is sensitive to hemolysis and erythrocyte enzymatic activities. We describe a new ELAT by using glucose oxidase (GO) linked to antihuman IgG. The optical density base line of GO-ELAT, al...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00098.x

    authors: Rigal D,Monestier M,Lafont S,Raffin T,Got A,Meyer F,Jouvenceaux A

    更新日期:1984-01-01 00:00:00

  • Evaluation of a combined HIV-1/2 and HTLV-I/II assay for screening blood donors.

    abstract::A combined immunoassay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II (Bioelisa, Launch Diagnostics) has been evaluated to determine its suitability for routine use in blood screening. 84,222 donations were tested from 76,452 donors. One HIV- and 1 HTLV-1-positive donor were identified. The spec...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb02576.x

    authors: Flanagan P,McAlpine L,Ramskill SJ,Smith AG,Eglin R,Parry JV,Mortimer PP

    更新日期:1995-01-01 00:00:00

  • Radioimmunoassay of hepatitis B core antigen and antibody with autologous reagents.

    abstract::Anti-HBc is the most sensitive indicator of current or recent hepatitis B virus infection, hence its detection is valuable in laboratory diagnosis of the infection. Dane particles isolated from the plasma of a single chronic carrier and his autologous IgG labeled with 125I were utilized in a solid-phase sandwich radio...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb02259.x

    authors: Vyas GN,Roberts IM

    更新日期:1977-12-01 00:00:00

  • Clinical consequences of the extremely rare anti-PP1Pk isoantibodies in pregnancy: a case series and review of the literature.

    abstract:BACKGROUND:The absence of the red cell antigens P, P1 and Pk , known as 'p', represents an extremely rare red cell phenotype. Individuals with this phenotype spontaneously form anti-PP1Pk isoantibodies, associated with severe haemolytic transfusion reactions, recurrent spontaneous abortion and haemolytic disease of the...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.13042

    authors: Di Ciaccio P,Cutts B,Alahakoon TI,Dennington PM,Soo LA,Curnow J

    更新日期:2020-12-16 00:00:00

  • Use of Fab anti-IgG in phenotyping IgG-sensitised red cells.

    abstract::Previously described methods of phenotyping red cells sensitised with IgG using the indirect antiglobulin test required the dissociation of the coating protein. Based on an entirely different principle, Fab fragments of anti-human IgG (Fab anti-IgG) were used to block the antiglobulin binding sites on cell-bound IgG m...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04939.x

    authors: Henry SM,Baird SJ,Woodfield DG

    更新日期:1987-01-01 00:00:00