Human alloantibodies detecting a red cell antigen apparently identical to MER2.

Abstract:

:Three examples of an antibody were found to be detecting a red cell polymorphism probably identical to MER2. The antibodies were made by Jews originating from India and living in Israel. Two of them were sibs and the third was unrelated. All 3 had kidney disease requiring renal dialysis and regular blood transfusion. In 2 cases the antibodies were detected before dialysis was started and before the patients had been transfused. The human antibodies reacted with red cells of 90% of Israeli blood donors tested. In tests on selected blood donors, 82 English and 56 Israeli, one of the human antibodies gave almost identical reactions to those given by monoclonal anti-MER2. Anomalous reactions were probably due to anti-Bga. Two of the human antibodies completely blocked, and one partially blocked, the reaction of monoclonal anti-MER2 with MER2+ red cells.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Daniels GL,Levene C,Berrebi A,Schechter Y,Moulds M,Sela R,Poole J,Lacey P,Atkins CJ

doi

10.1111/j.1423-0410.1988.tb05085.x

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

161-4

issue

3

eissn

0042-9007

issn

1423-0410

journal_volume

55

pub_type

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