Abstract:
:The factors that impact upon successful bone marrow transplantation leading to immunologic reconstitution in severe combined immune deficiency (SCID). Wiskott-Aldrich syndrome, and in other lethal congenital immunodeficiencies are reviewed. Evidence is presented that graft-versus-host disease (GVHD) can be abrogated by the depletion of T cells, even from histoincompatible marrow grafts. However, graft resistance or restricted immune reconstitution has been observed with significant frequency. The bases for T cell reconstitution and limitations in B cell humoral immune recovery in the postgrafting period are reviewed, together with emerging evidence that pretransplant cytoreduction might obviate some of these problems.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
O'Reilly RJ,Brochstein J,Collins N,Keever C,Kapoor N,Kirkpatrick D,Kernan N,Dupont B,Burns J,Reisner Ydoi
10.1111/j.1423-0410.1986.tb02013.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
81-6eissn
0042-9007issn
1423-0410journal_volume
51 Suppl 2pub_type
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