Segregation of proteins and sodium in human plasma upon freezing.

Abstract:

:The proteins and sodium in human source blood plasma are segregated and concentrated on freezing, particularly in plasma that is frozen slowly in a large container. The temperature and the concentration gradients at the freezing front induce a convection in the liquid phase and thus play the primary role in the segregation of proteins and sodium in the frozen mass. Unidirectional freezing, where the freezing front moves against gravity, minimizes segregation because the density gradient-induced convection is minimized at the solid-liquid interface. Microscopic observation of the freezing front of the plasma indicates that ice crystals are the primary solid formed. Their shape is generally irregular, and they become highly dendritic as the freezing rate increases. Apparently, the liquid phase at the freezing front is trapped between the ice crystals; it then undergoes a complex secondary freezing process at a lower temperature behind the primary freezing front of the ice crystals.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Chang CE

doi

10.1111/j.1423-0410.1983.tb01890.x

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

238-45

issue

4

eissn

0042-9007

issn

1423-0410

journal_volume

44

pub_type

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