Abstract:
:A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include proinflammatory cytokines, adhesion molecules, and matrix degrading enzymes. At the transcriptional level, they are regulated by the histone deacetylase sirtuin (SIRT) 1 via its actions on the proinflammatory transcription factor nuclear factor-κB (NF-κB). The role of SIRT6, also a histone deacetylase, in regulating inflammation in endothelial cells is not known. The aim of this study was to determine the effect of SIRT6 knockdown on inflammatory markers in human umbilical vein endothelial cells (HUVECs) in the presence of lipopolysaccharide (LPS). LPS decreased expression of SIRT6 in HUVECs. Knockdown of SIRT6 increased the expression of proinflammatory cytokines (IL-1β, IL-6, IL-8), COX-prostaglandin system, ECM remodelling enzymes (MMP-2, MMP-9 and PAI-1), the adhesion molecule ICAM-1, and proangiogenic growth factors VEGF and FGF-2; cell migration; cell adhesion to leukocytes. Loss of SIRT6 increased the expression of NF-κB, whereas overexpression of SIRT6 was associated with decreased NF-κB transcriptional activity. Taken together, these results demonstrate that the loss of SIRT6 in endothelial cells is associated with upregulation of genes involved in inflammation, vascular remodelling, and angiogenesis. SIRT6 may be a potential pharmacological target for inflammatory vascular diseases.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Lappas Mdoi
10.1155/2012/597514subject
Has Abstractpub_date
2012-01-01 00:00:00pages
597514eissn
0962-9351issn
1466-1861journal_volume
2012pub_type
杂志文章abstract::Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6012795
更新日期:2017-01-01 00:00:00
abstract::Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory pro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/942159
更新日期:2015-01-01 00:00:00
abstract::Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinfl...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7650978
更新日期:2020-07-23 00:00:00
abstract::To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/287381
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/823279
更新日期:2011-01-01 00:00:00
abstract::Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences shows that MDSC...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/159269
更新日期:2015-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890983
更新日期:1998-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3685948
更新日期:2018-09-26 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2945650
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2018/3809092.]. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,已发布勘误
doi:10.1155/2019/4524179
更新日期:2019-06-18 00:00:00
abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/792393
更新日期:2010-01-01 00:00:00
abstract::Behçet's disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways. The objective of this study was to investigate the association of the DC stimulatory molecu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/5761392
更新日期:2019-09-09 00:00:00
abstract::Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6173893
更新日期:2019-06-25 00:00:00
abstract:Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4798209
更新日期:2018-06-28 00:00:00
abstract::Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6573802
更新日期:2017-01-01 00:00:00
abstract::Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/804298
更新日期:2010-01-01 00:00:00
abstract::Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/7501985
更新日期:2018-11-18 00:00:00
abstract::We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3859856
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients with gonarthrosis comparing two methods of isolation and to investigate their immune regulatory properties. Extracellular vesicles (EVs) have been isolated from inflamed SF by polymer precipitation method and quantified by ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4814987
更新日期:2017-01-01 00:00:00
abstract::The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/804167
更新日期:2015-01-01 00:00:00
abstract::Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/432785
更新日期:2014-01-01 00:00:00
abstract::Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/606819
更新日期:2015-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/267590
更新日期:2015-01-01 00:00:00
abstract::TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/909827
更新日期:2015-01-01 00:00:00
abstract::Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/515048
更新日期:2013-01-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is a major worldwide health problem. Chronic infection induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual cirrhosis, and possible hepatocellular carcinoma. Eradication of the virus is one of the most important treatment aims. A number of promising ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/6841628
更新日期:2016-01-01 00:00:00
abstract::Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 pa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000518
更新日期:1996-01-01 00:00:00
abstract::Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4316316
更新日期:2017-01-01 00:00:00
abstract::There is much evidence that degradation of the extracellular matrix is essential for the development of cholesteatomas and that this is induced by activation of matrix metalloproteinases (MMPs). Vitamin D3 (VD3) has several well-recognised biological activities, including suppression of MMP production. The present stu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.210
更新日期:2005-08-31 00:00:00
abstract:BACKGROUND AND AIM:Immunization with live virus vaccines may cause an immunosuppression with lymphopaenia, impaired cytokine production and defective lymphocyte response to mitogenes. These abnormalities were described in subjects vaccinated against measles. This study was performed to analyse the host immune response ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350310001599639
更新日期:2003-08-01 00:00:00