Abstract:
:Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucosa biopsies from 11 patients who underwent irradiation for prostate cancer were examined immunohistochemically for the expression of VEGF and CD31 at three time settings-before, at the completion of, and 6 months after radiotherapy. VEGF expressing vascular endothelial cells and CD31 expressing microvessels were counted separately in 10 high-power fields (HPFs). VEGF vascular index (VEGF-VI) and microvascular density (MVD) were calculated as the mean number of VEGF positive cells per vessel or the mean number of vessels per HPF, respectively. Histological features were also evaluated. Results. VEGF-VI was significantly higher at the completion of radiotherapy (0.17 ± 0.15 versus 0.41 ± 0.24, P = 0.001) declining 6 months after. MVD increased significantly only 6 months after radiotherapy (7.3 ± 3.2 versus 10.5 ± 3.1, P < 0.005). The histopathological examination revealed inflammatory changes at the completion of radiotherapy regressing in the majority of cases 6 months after. Conclusions. Our results showed that in postradiation rectal biopsy specimens neoangiogenesis seems to be inflammation-related and constitutes a significant postradiation component of the tissue injury.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Karamanolis G,Delladetsima I,Kouloulias V,Papaxoinis K,Panayiotides I,Haldeopoulos D,Triantafyllou K,Kelekis N,Ladas SDdoi
10.1155/2013/515048subject
Has Abstractpub_date
2013-01-01 00:00:00pages
515048eissn
0962-9351issn
1466-1861journal_volume
2013pub_type
杂志文章abstract::The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/354087
更新日期:2013-01-01 00:00:00
abstract::TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/909827
更新日期:2015-01-01 00:00:00
abstract::Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350120093731
更新日期:2001-10-01 00:00:00
abstract::Exposure to hog barn organic dust contributes to occupational lung diseases, which are mediated by inflammatory and oxidative stress pathways. Isoprostanes-a family of eicosanoids produced by oxidation of phospholipids by oxygen radicals-are biomarkers of pulmonary oxidative stress. Importantly, 8-isoprostane has been...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/7420468
更新日期:2019-08-01 00:00:00
abstract::The effects of anti-inflammatory plant extracts, such as black tea extract (BTE) and resveratrol (RSV) could modulate cell activation leading to atherosclerosis, however there is little comparative information about how different endothelial cell types are affected by these compounds. In order to compare human endothe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/146872
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases. OBJECTIVE:To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/708608
更新日期:2014-01-01 00:00:00
abstract::Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4786170
更新日期:2017-01-01 00:00:00
abstract::Incubation of rat hepatocytes in primary culture with IL-1beta at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (-35%) in the amount of apoE mRNA, but increased apoE synthesi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000498
更新日期:1992-01-01 00:00:00
abstract::The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359891162
更新日期:1998-01-01 00:00:00
abstract::Sanguisorbae Radix (SR) is well known as herbal medicine named "Zi-Yu" in Korea, which is the dried roots of Sanguisorba officinalis L. (Rosacease). We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2947390
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY:To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD:The eff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350410001664798
更新日期:2004-02-01 00:00:00
abstract::Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body's response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, pr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/979748
更新日期:2013-01-01 00:00:00
abstract::Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9524594
更新日期:2017-01-01 00:00:00
abstract::The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/690525
更新日期:2012-01-01 00:00:00
abstract::To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/287381
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/461536
更新日期:2013-01-01 00:00:00
abstract:Background:Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods:Fifty Sprague...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5301312
更新日期:2017-01-01 00:00:00
abstract::The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000610
更新日期:1996-01-01 00:00:00
abstract:Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7610436
更新日期:2020-05-22 00:00:00
abstract:OBJECTIVE:TRAIL is a potential biomarker of cardiovascular (CV) disease. Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with metabolic syndrome (MeS) and accelerated atherosclerosis. We assessed whether disease activity, systemic inflammation, and MeS features were associated with circulating ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/798060
更新日期:2014-01-01 00:00:00
abstract::Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4316316
更新日期:2017-01-01 00:00:00
abstract::Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/134605
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone. AIMS:To investigate levels of AA metabolites in BAL fluid, before and...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1080/09629350123056
更新日期:2001-02-01 00:00:00
abstract::Early onset sepsis due to group B streptococcus leads to neonatal morbidity, increased mortality, and long-term neurological deficencies. Interaction between septicemic GBS and confluent monolayers of human coronary artery endothelial cells (HCAECs) was analyzed by genome wide expression profiling. In total, 124 genes...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/971502
更新日期:2011-01-01 00:00:00
abstract::Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investiga...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4267158
更新日期:2018-03-18 00:00:00
abstract::Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induced skeletal muscle i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/865159
更新日期:2013-01-01 00:00:00
abstract::Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2120971
更新日期:2020-04-03 00:00:00
abstract::Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a c...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/1601486
更新日期:2018-02-18 00:00:00
abstract::OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020002877
更新日期:2000-01-01 00:00:00
abstract::It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/823486
更新日期:2010-01-01 00:00:00