Abstract:
:Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body's response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. Using new proteomic technology, we have investigated serum profile of pro- (IL-1β , IL-6, IL-8, IL-12, GM-CSF, and TNF-α ) and anti-inflammatory cytokines (IL-4, IL-10), along with angiogenic factors (VEGF, bFGF) in order to assess tumoural aggressiveness. Our results indicate significant dysregulation in serum levels of cytokines and angiogenic factors, with over threefold upregulation of IL-6, IL-1β , TNF-α , and IL-10 and up to twofold upregulation of VEGF, FGF-2, IL-8, IL-2, and GM-CSF. These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Albulescu R,Codrici E,Popescu ID,Mihai S,Necula LG,Petrescu D,Teodoru M,Tanase CPdoi
10.1155/2013/979748subject
Has Abstractpub_date
2013-01-01 00:00:00pages
979748eissn
0962-9351issn
1466-1861journal_volume
2013pub_type
杂志文章abstract::Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1080/09629350400003118
更新日期:2004-08-01 00:00:00
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350410001664798
更新日期:2004-02-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
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journal_title:Mediators of inflammation
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pub_type: 临床试验,杂志文章
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journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/680853
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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