Predictive factors of response to biological disease modifying antirheumatic drugs: towards personalized medicine.

abstract：:Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple cytokines. Although dysregulation of interleukin- (IL-) 22 is invol...

journal_title：Mediators of inflammation

authors： Liang M,Wang J,Chu H,Zhu X,He H,Liu Q,Qiu J,Zhou X,Guan M,Xue Y,Chen X,Zou H

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation ofthe immune system, in patients with histologically verified chronic active hepatitis associated to hepatitis C virus infection, with those in healthy subjects. S...

journal_title：Mediators of inflammation

authors： Caruso C,Candore G,Cigna D,Tripi S,Di Gaetano G,Migneco G,Montalto G,Ruggieri I,Notarbartolo A

更新日期：1994-01-01 00:00:00

abstract：:Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF-...

journal_title：Mediators of inflammation

authors： Zarzynska JM

更新日期：2014-01-01 00:00:00

abstract：Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...

journal_title：Mediators of inflammation

authors： Vitale A,Sota J,Obici L,Ricco N,Maggio MC,Cattalini M,Ruscitti P,Caso F,Manna R,Viapiana O,Caggiano V,Emmi G,Insalaco A,Montin D,Licciardi F,Soriano A,Dagna L,Salvarani C,Lamacchia V,Hernández-Rodríguez J,Giacomel

更新日期：2020-05-27 00:00:00

abstract：:Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression ...

journal_title：Mediators of inflammation

authors： Plawecki M,Morena M,Kuster N,Chenine L,Leray-Moragues H,Jover B,Fesler P,Lotierzo M,Dupuy AM,Klouche K,Cristol JP

更新日期：2018-10-08 00:00:00

abstract：:Background. Patients with UC have shown an important defect in the secretion and maintenance of the mucosal barrier as part of inadequate expression of mucin genes. The aim of the present study was to determine the expression of MUC12, MUC16, and MUC20 in colonic tissue from patients with UC in regard to their clinica...

journal_title：Mediators of inflammation

authors： Yamamoto-Furusho JK,Ascaño-Gutiérrez I,Furuzawa-Carballeda J,Fonseca-Camarillo G

更新日期：2015-01-01 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00

abstract：:In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3(+) CD4(+) T cell subsets in sarcoidosis remains unclear. Bronchoalveolar lavage fluid ce...

journal_title：Mediators of inflammation

authors： Tøndell A,Moen T,Børset M,Salvesen Ø,Rø AD,Sue-Chu M

更新日期：2014-01-01 00:00:00

abstract：:Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...

journal_title：Mediators of inflammation

authors： Passos BN,Lima MC,Sierra APR,Oliveira RA,Maciel JFS,Manoel R,Rogante JI,Pesquero JB,Cury-Boaventura MF

更新日期：2019-10-07 00:00:00

abstract：:The objective of this study was to evaluate the effects of peptides derived from synbiotics on improving inflammatory bowel disease (IBD). Five-week-old male C57BL/6 mice were administered with dextran sulfate sodium (DSS) via drinking water for seven days to induce IBD (IBD group). The mice in the IBD group were oral...

journal_title：Mediators of inflammation

authors： Ha J,Oh H,Oh NS,Seo Y,Kang J,Park MH,Kim KS,Kang SH,Yoon Y

更新日期：2020-07-04 00:00:00

abstract：:Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...

journal_title：Mediators of inflammation

authors： Fernandes ES,Brito CX,Teixeira SA,Barboza R,dos Reis AS,Azevedo-Santos AP,Muscará M,Costa SK,Marinho CR,Brain SD,Grisotto MA

更新日期：2014-01-01 00:00:00

abstract：:Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137 signaling activation was activated by agonis...

journal_title：Mediators of inflammation

authors： Zhong W,Li B,Li XY,Wang ZQ,Shao C,Wang CP,Chen R,Yan JC

更新日期：2017-01-01 00:00:00

abstract：:Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contrib...

journal_title：Mediators of inflammation

authors： Stunault MI,Bories G,Guinamard RR,Ivanov S

更新日期：2018-12-10 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and infla...

journal_title：Mediators of inflammation

authors： Li Y,Wang Y,Liu Y,Wang Y,Zuo X,Li Y,Lu X

更新日期：2014-01-01 00:00:00

abstract：:Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...

journal_title：Mediators of inflammation

authors： Branco ACCC,Yoshikawa FSY,Pietrobon AJ,Sato MN

更新日期：2018-08-27 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...

journal_title：Mediators of inflammation

authors： Cerezo LA,Kuklová M,Hulejová H,Vernerová Z,Kaspříková N,Veigl D,Pavelka K,Vencovský J,Šenolt L

更新日期：2015-01-01 00:00:00

abstract：:Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; correc...

journal_title：Mediators of inflammation

authors： Naruse K,Noguchi T,Sado T,Tsunemi T,Shigetomi H,Kanayama S,Akasaka J,Koike N,Oi H,Kobayashi H

更新日期：2012-01-01 00:00:00

abstract：:The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammato...

journal_title：Mediators of inflammation

authors： Fuentes E,Fuentes F,Vilahur G,Badimon L,Palomo I

更新日期：2013-01-01 00:00:00

abstract：:Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...

journal_title：Mediators of inflammation

authors： Memmert S,Damanaki A,Nogueira AVB,Eick S,Nokhbehsaim M,Papadopoulou AK,Till A,Rath B,Jepsen S,Götz W,Piperi C,Basdra EK,Cirelli JA,Jäger A,Deschner J

更新日期：2017-01-01 00:00:00

abstract：:The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill patients. Despite decades of research, few therapeutic strategies for clinical ARDS have emerged. Here we carefully evaluated the effect o...

journal_title：Mediators of inflammation

authors： Guo Z,Li Q,Han Y,Liang Y,Xu Z,Ren T

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...

journal_title：Mediators of inflammation

authors： Wei CC,Ping DQ,You FT,Qiang CY,Tao C

更新日期：2016-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are multifactorial disorders resulting from environmental and genetic factors. Polymorphisms in MDR1 and GSTs genes might explain individual differences in susceptibility to IBD. We carried out a case-control study to examine the association of MDR1 (C1236T and C3435T), GSTT1, and GST...

journal_title：Mediators of inflammation

authors： Senhaji N,Kassogue Y,Fahimi M,Serbati N,Badre W,Nadifi S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...

journal_title：Mediators of inflammation

authors： Pawlowski P,Reszec J,Eckstein A,Johnson K,Grzybowski A,Chyczewski L,Mysliwiec J

更新日期：2014-01-01 00:00:00

abstract：:Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...

journal_title：Mediators of inflammation

authors： Vodo S,Bechi N,Petroni A,Muscoli C,Aloisi AM

更新日期：2013-01-01 00:00:00

abstract：:The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...

journal_title：Mediators of inflammation

authors： Westin U,Lundberg E,Ohlsson K

更新日期：1998-01-01 00:00:00

abstract：:Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...

journal_title：Mediators of inflammation

authors： Oviedo-Boyso J,Bravo-Patiño A,Baizabal-Aguirre VM

更新日期：2014-01-01 00:00:00

abstract：:Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 +/...

journal_title：Mediators of inflammation

authors： Taquet N,Dumont S,Vonesch JL,Hentsch D,Reimund JM,Muller CD

更新日期：2009-01-01 00:00:00

abstract：STUDY OBJECTIVES:To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome. METHODS:We studied prospectively 57 consecutive patients with PPE (empyema (EMP), complicated (CPE), and uncomplicated parapneumonic effu...

journal_title：Mediators of inflammation

authors： Boultadakis V,Skouras V,Makris D,Damianaki A,Nikoulis DJ,Kiropoulos T,Oikonomidi S,Tsilioni I,Gourgoulianis K

更新日期：2011-01-01 00:00:00

abstract：:Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...

journal_title：Mediators of inflammation

authors： Dunne MR,Mangan BA,Madrigal-Estebas L,Doherty DG

更新日期：2010-01-01 00:00:00