Abstract:
:Inflammatory bowel diseases (IBD) are multifactorial disorders resulting from environmental and genetic factors. Polymorphisms in MDR1 and GSTs genes might explain individual differences in susceptibility to IBD. We carried out a case-control study to examine the association of MDR1 (C1236T and C3435T), GSTT1, and GSTM1 polymorphisms with the risk of IBD. Subjects were genotyped using PCR-RFLP for MDR1 gene and multiplex PCR for GSTT1 and GSTM1. Meta-analysis was performed to test the association of variant allele carriage with IBD risk. We report that GSTT1 null genotype is significantly associated with the risk of CD (OR: 2.5, CI: 1.2-5, P = 0.013) and UC (OR: 3.5, CI: 1.5-8.5, P = 0.004) and can influence Crohn's disease behavior. The interaction between GSTT1 and GSTM1 genes showed that the combined null genotypes were associated with the risk of UC (OR: 3.1, CI: 1.1-9, P = 0.049). Furthermore, when compared to combined 1236CC/CT genotypes, the 1236TT genotype of MDR1 gene was associated with the risk of UC (OR: 3.7, CI: 1.3-10.7, P = 0.03). Meta-analysis demonstrated significantly higher frequencies of 3435T carriage in IBD patients. Our results show that GSTT1 null and MDR1 polymorphisms could play a role in susceptibility to IBD.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Senhaji N,Kassogue Y,Fahimi M,Serbati N,Badre W,Nadifi Sdoi
10.1155/2015/248060subject
Has Abstractpub_date
2015-01-01 00:00:00pages
248060eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
杂志文章,meta分析abstract::We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890875
更新日期:1998-01-01 00:00:00
abstract::Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14(hi) TIMP-3(lo) rabbit foam cells are more invasive and more prone to apoptosis than MMP-14(lo) TIMP-3(hi) cells. We investigated the implica...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/276457
更新日期:2014-01-01 00:00:00
abstract::The development of an acidic tissue environment is a hallmark of a variety of inflammatory processes and solid tumors. However, little attention has been paid so far to analyze the influence exerted by extracellular pH on the immune response. Tissue acidosis (pH 6.0 to 7.0) is usually associated with the course of inf...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/1218297
更新日期:2018-12-30 00:00:00
abstract::Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 c...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/205156
更新日期:2015-01-01 00:00:00
abstract::The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.2
更新日期:2005-02-24 00:00:00
abstract::Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3421897
更新日期:2018-11-28 00:00:00
abstract::In addition to its well-established effect on T cells, cyclosporin A (CsA) also inhibits inflammatory cytokine production by macrophages. However, little is known about the mechanism of action of CsA on macrophage cytokine production. We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulate...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990423
更新日期:1999-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8172706
更新日期:2016-01-01 00:00:00
abstract:Background:Gut barrier dysfunction with alterant mucosal permeability during sepsis is a challenge problem in clinical practice. Intestinal epithelial cells (IECs) are strongly involved in mucosal oxidative stress and inflammatory response. The current study aimed at investigating the effect of MitoQ, a mitochondrial t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3276148
更新日期:2020-04-11 00:00:00
abstract::Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data abou...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/3271579
更新日期:2016-01-01 00:00:00
abstract::Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/606819
更新日期:2015-01-01 00:00:00
abstract::Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/804298
更新日期:2010-01-01 00:00:00
abstract:AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1080/09629350400003118
更新日期:2004-08-01 00:00:00
abstract::The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359891162
更新日期:1998-01-01 00:00:00
abstract::Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/274025
更新日期:2015-01-01 00:00:00
abstract::Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3952526
更新日期:2018-10-08 00:00:00
abstract:BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has be...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350220131944
更新日期:2002-04-01 00:00:00
abstract::Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.385
更新日期:2005-12-14 00:00:00
abstract::There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a "firebreak" to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or st...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/409596
更新日期:2015-01-01 00:00:00
abstract::Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine protei...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/165453
更新日期:2013-01-01 00:00:00
abstract::Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintena...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/967629
更新日期:2012-01-01 00:00:00
abstract::Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was e...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/1927348
更新日期:2016-01-01 00:00:00
abstract::Bortezomib is a proteasome inhibitor used for hematologic cancer treatment. Since it can suppress NF-κB activation, which is critical for the inflammatory process, bortezomib has been found to possess anti-inflammatory activity. In this study, we evaluated the effect of bortezomib on experimental autoimmune uveitis (E...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/847373
更新日期:2015-01-01 00:00:00
abstract:Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5270657
更新日期:2018-06-21 00:00:00
abstract:OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/490406
更新日期:2010-01-01 00:00:00
abstract::Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were expo...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000050
更新日期:1994-01-01 00:00:00
abstract:Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/5650627
更新日期:2017-01-01 00:00:00
abstract:Objective:Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7903140
更新日期:2020-08-04 00:00:00
abstract::A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6716419
更新日期:2017-01-01 00:00:00
abstract::High-fructose diet induced changes in gut microbiota structure and function, which have been linked to inflammatory response. However, the effect of small or appropriate doses of fructose on gut microbiota and inflammatory cytokines is not fully understood. Hence, the abundance changes of gut microbiota in fructose-tr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/6672636
更新日期:2020-11-30 00:00:00