Unravelling the Interplay between Extracellular Acidosis and Immune Cells.

Abstract:

:The development of an acidic tissue environment is a hallmark of a variety of inflammatory processes and solid tumors. However, little attention has been paid so far to analyze the influence exerted by extracellular pH on the immune response. Tissue acidosis (pH 6.0 to 7.0) is usually associated with the course of infectious processes in peripheral tissues. Moreover, it represents a prominent feature of solid tumors. In fact, values of pH ranging from 5.7 to 7.0 are usually found in a number of solid tumors such as breast cancer, brain tumors, sarcomas, malignant melanoma, squamous cell carcinomas, and adenocarcinomas. Both the innate and adaptive arms of the immune response appear to be finely regulated by extracellular acidosis in the range of pH values found at inflammatory sites and tumors. Low pH has been shown to delay neutrophil apoptosis, promoting their differentiation into a proangiogenic profile. Acting on monocytes and macrophages, it induces the activation of the inflammasome and the production of IL-1β, while the exposure of conventional dendritic cells to low pH promotes the acquisition of a mature phenotype. Overall, these observations suggest that high concentrations of protons could be recognized by innate immune cells as a danger-associated molecular pattern (DAMP). On the other hand, by acting on T lymphocytes, low pH has been shown to suppress the cytotoxic response mediated by CD8+ T cells as well as the production of IFN-γ by TH1 cells. Interestingly, modulation of tumor microenvironment acidity has been shown to be able not only to reverse anergy in human and mouse tumor-infiltrating T lymphocytes but also to improve the antitumor immune response induced by checkpoint inhibitors. Here, we provide an integrated view of the influence exerted by low pH on immune cells and discuss its implications in the immune response against infectious agents and tumor cells.

journal_name

Mediators Inflamm

authors

Erra Díaz F,Dantas E,Geffner J

doi

10.1155/2018/1218297

subject

Has Abstract

pub_date

2018-12-30 00:00:00

pages

1218297

eissn

0962-9351

issn

1466-1861

journal_volume

2018

pub_type

杂志文章,评审
  • Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study.

    abstract::Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/6012795

    authors: Posadas-Sánchez R,Pérez-Hernández N,Angeles-Martínez J,López-Bautista F,Villarreal-Molina T,Rodríguez-Pérez JM,Fragoso JM,Posadas-Romero C,Vargas-Alarcón G

    更新日期:2017-01-01 00:00:00

  • Testosterone-induced effects on lipids and inflammation.

    abstract::Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2013/183041

    authors: Vodo S,Bechi N,Petroni A,Muscoli C,Aloisi AM

    更新日期:2013-01-01 00:00:00

  • Pulmonary granulocyte influx and impaired alveolar macrophage adenylyl cyclase responsiveness in developing respiratory distress.

    abstract::Alveolar macrophages have recently been postulated as being involved in the aetiology of adult respiratory distress syndrome (ARDS). To evaluate their role, basal cyclic AMP levels and responsiveness of adenylyl cyclase alveolar macrophages were determined at four intermediate stages of developing respiratory distress...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/S0962935193000341

    authors: Amsterdam JG,Heijde RM,Grotjohan HP,Beusenberg FD

    更新日期:1993-01-01 00:00:00

  • Association of Daily Dietary Intake and Inflammation Induced by Marathon Race.

    abstract::Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...

    journal_title:Mediators of inflammation

    pub_type: 临床试验,杂志文章

    doi:10.1155/2019/1537274

    authors: Passos BN,Lima MC,Sierra APR,Oliveira RA,Maciel JFS,Manoel R,Rogante JI,Pesquero JB,Cury-Boaventura MF

    更新日期:2019-10-07 00:00:00

  • Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors.

    abstract::Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/9398401

    authors: Hsu LA,Wu S,Juang JJ,Chiang FT,Teng MS,Lin JF,Huang HL,Ko YL

    更新日期:2017-01-01 00:00:00

  • The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages.

    abstract::Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,收录出版

    doi:10.1155/2018/4514329

    authors: Chung HJ,Koh W,Kim WK,Shin JS,Lee J,Lee SK,Ha IH

    更新日期:2018-04-05 00:00:00

  • Endotoxin and cytokines in patients with gastrointestinal tract perforation.

    abstract::Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml(-1). The clinical outcome correlated with the level of tumour necrosis factor alpha (...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/S0962935192000097

    authors: Endo S,Inada K,Inoue Y,Otsu T,Kasai T,Kuwata Y,Hoshi S,Yoshida M

    更新日期:1992-01-01 00:00:00

  • Effects of Er,Cr:YSGG and Diode Lasers on Clinical Parameters and Gingival Crevicular Fluid IL-1β and IL-37 Levels in Generalized Aggressive Periodontitis.

    abstract:Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/2780794

    authors: Talmac AC,Calisir M,Eroglu EG,Ertugrul AS

    更新日期:2019-06-12 00:00:00

  • The traditional Japanese formula keishibukuryogan inhibits the production of inflammatory cytokines by dermal endothelial cells.

    abstract::Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2010/804298

    authors: Yoshihisa Y,Furuichi M,Ur Rehman M,Ueda C,Makino T,Shimizu T

    更新日期:2010-01-01 00:00:00

  • Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling.

    abstract::To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/287381

    authors: Song HT,Qin Y,Yao GD,Tian ZN,Fu SB,Geng JS

    更新日期:2014-01-01 00:00:00

  • Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells.

    abstract::Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2020/7039854

    authors: Chai Y,Yu R,Liu Y,Wang S,Yuan D,Chen J

    更新日期:2020-02-10 00:00:00

  • L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure.

    abstract::Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock. Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2012/210454

    authors: Brenner T,Fleming TH,Rosenhagen C,Krauser U,Mieth M,Bruckner T,Martin E,Nawroth PP,Weigand MA,Bierhaus A,Hofer S

    更新日期:2012-01-01 00:00:00

  • Activation of Macrophages by Oligomeric Proteins of Different Size and Origin.

    abstract::Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2018/7501985

    authors: Dalgėdienė I,Lučiūnaitė A,Žvirblienė A

    更新日期:2018-11-18 00:00:00

  • NF-κB signaling in the brain of autistic subjects.

    abstract::Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2011/785265

    authors: Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

    更新日期:2011-01-01 00:00:00

  • Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain.

    abstract::Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems and in conditions of neuropa...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2013/480739

    authors: Ramesh G,MacLean AG,Philipp MT

    更新日期:2013-01-01 00:00:00

  • Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer.

    abstract::Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences shows that MDSC...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2015/159269

    authors: Katoh H,Watanabe M

    更新日期:2015-01-01 00:00:00

  • Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis.

    abstract:BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2016/9529630

    authors: Wei CC,Ping DQ,You FT,Qiang CY,Tao C

    更新日期:2016-01-01 00:00:00

  • Proteinase-activated receptor-1 and immunomodulatory effects of a PAR1-activating peptide in a mouse model of prostatitis.

    abstract:BACKGROUND:Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. METHODS:Using a hapten (ethanol-dinitr...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2013/748395

    authors: Stanton MM,Nelson LK,Benediktsson H,Hollenberg MD,Buret AG,Ceri H

    更新日期:2013-01-01 00:00:00

  • Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results.

    abstract::The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2016/5302120

    authors: Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Z

    更新日期:2016-01-01 00:00:00

  • Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion.

    abstract::The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study. We found that the plasma concentrations and protein expressions of TGF-β1 were s...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2016/4158287

    authors: Salma U,Xue M,Ali Sheikh MS,Guan X,Xu B,Zhang A,Huang L,Xu D

    更新日期:2016-01-01 00:00:00

  • Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells.

    abstract::A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include proinflammatory cytokines, adhesion molecules, and matrix degrading enzymes. At the transcriptional level, they are regulated by the histone deacetylase sirtuin (SIRT) 1 via its actions on t...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2012/597514

    authors: Lappas M

    更新日期:2012-01-01 00:00:00

  • Suppression of neutrophil recruitment in mice by geranium essential oil.

    abstract:BACKGROUND:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY:To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD:The eff...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1080/09629350410001664798

    authors: Abe S,Maruyama N,Hayama K,Inouye S,Oshima H,Yamaguchi H

    更新日期:2004-02-01 00:00:00

  • The Monocyte-to-Lymphocyte Ratio at Hospital Admission Is a Novel Predictor for Acute Traumatic Intraparenchymal Hemorrhage Expansion after Cerebral Contusion.

    abstract:Purpose:To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2020/5483981

    authors: Sheng J,Li T,Zhuang D,Cai S,Yang J,Ding F,Chen X,Tian F,Huang M,Li L,Li K,Chen W

    更新日期:2020-12-28 00:00:00

  • Corrigendum to "Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer".

    abstract::[This corrects the article DOI: 10.1155/2019/2056085.]. ...

    journal_title:Mediators of inflammation

    pub_type: 已发布勘误

    doi:10.1155/2020/2195341

    authors: Pacheco-Fernández T,Juárez-Avelar I,Illescas O,Terrazas LI,Hernández-Pando R,Pérez-Plasencia C,Gutiérrez-Cirlos EB,Ávila-Moreno F,Chirino YI,Reyes JL,Maldonado V,Rodriguez-Sosa M

    更新日期:2020-06-17 00:00:00

  • Auricular Cartilage Regeneration with Adipose-Derived Stem Cells in Rabbits.

    abstract::Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investiga...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2018/4267158

    authors: Oh SJ,Park HY,Choi KU,Choi SW,Kim SD,Kong SK,Cho KS

    更新日期:2018-03-18 00:00:00

  • Inflammation and the peritoneal membrane: causes and impact on structure and function during peritoneal dialysis.

    abstract::Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2012/912595

    authors: Baroni G,Schuinski A,de Moraes TP,Meyer F,Pecoits-Filho R

    更新日期:2012-01-01 00:00:00

  • Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages.

    abstract::Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2020/3824593

    authors: Zhang L,Haddouti EM,Beckert H,Biehl R,Pariyar S,Rüwald JM,Li X,Jaenisch M,Burger C,Wirtz DC,Kabir K,Schildberg FA

    更新日期:2020-12-03 00:00:00

  • The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes.

    abstract::Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/6157491

    authors: Bayer A,Lammel J,Tohidnezhad M,Lippross S,Behrendt P,Klüter T,Pufe T,Cremer J,Jahr H,Rademacher F,Gläser R,Harder J

    更新日期:2017-01-01 00:00:00

  • Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates the gene and protein expression of inflammation biomarkers induced by trans-fatty acids in the colon of offspring.

    abstract::Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in of...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/987927

    authors: Almeida Morais C,Oyama LM,de Oliveira JL,Carvalho Garcia M,de Rosso VV,Sousa Mendes Amigo L,do Nascimento CM,Pisani LP

    更新日期:2014-01-01 00:00:00

  • Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease.

    abstract::Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9890141

    authors: Bryan PF,Karla C,Edgar Alejandro MT,Sara Elva EP,Gemma F,Luz C

    更新日期:2016-01-01 00:00:00