Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability.

abstract：:The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised ...

journal_title：Mediators of inflammation

authors： Sallam N,Khazaei M,Laher I

更新日期：2010-01-01 00:00:00

abstract：:S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...

journal_title：Mediators of inflammation

authors： Lovati AB,Drago L,Bottagisio M,Bongio M,Ferrario M,Perego S,Sansoni V,De Vecchi E,Romanò CL

更新日期：2016-01-01 00:00:00

abstract：:Recently, we revealed the importance of follicular helper T cells (T(FH)) in the pathogenesis of primary Sjögren's syndrome (pSS). In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on ...

journal_title：Mediators of inflammation

authors： Szabo K,Papp G,Dezso B,Zeher M

更新日期：2014-01-01 00:00:00

abstract：:Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine protei...

journal_title：Mediators of inflammation

authors： Yang H,Li T,Wei J,Zhang H,He S

更新日期：2013-01-01 00:00:00

abstract：:Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients w...

journal_title：Mediators of inflammation

authors： Lenglet S,Quercioli A,Fabre M,Galan K,Pelli G,Nencioni A,Bauer I,Pende A,Python M,Bertolotto M,Spinella G,Pane B,Palombo D,Dallegri F,Mach F,Vuilleumier N,Montecucco F

更新日期：2014-01-01 00:00:00

abstract：:The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...

journal_title：Mediators of inflammation

authors： Westin U,Lundberg E,Ohlsson K

更新日期：1998-01-01 00:00:00

abstract：:This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...

journal_title：Mediators of inflammation

authors： Varriano MA,Varriano AA,Datti F,Datti M,Antunes E,Teixeira NA

更新日期：2001-08-01 00:00:00

abstract：:Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...

journal_title：Mediators of inflammation

authors： Wang W,Xu D,Wang B,Yan S,Wang X,Yin Y,Wang X,Sun B,Sun X

更新日期：2015-01-01 00:00:00

abstract：:The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...

journal_title：Mediators of inflammation

authors： Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Z

更新日期：2016-01-01 00:00:00

abstract：:Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...

journal_title：Mediators of inflammation

authors： Costantini E,D'Angelo C,Reale M

更新日期：2018-03-08 00:00:00

abstract：BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...

journal_title：Mediators of inflammation

authors： Brandt C,Pedersen M,Rinnov A,Andreasen AS,Møller K,Hojman P,Pedersen BK,Plomgaard P

更新日期：2014-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

journal_title：Mediators of inflammation

authors： Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

更新日期：2011-01-01 00:00:00

abstract：:In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors...

journal_title：Mediators of inflammation

authors： Capone F,Guerriero E,Sorice A,Colonna G,Ciliberto G,Costantini S

更新日期：2016-01-01 00:00:00

abstract：:The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...

journal_title：Mediators of inflammation

authors： Safrankova B,Gajdova S,Kubala L

更新日期：2010-01-01 00:00:00

abstract：:To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...

journal_title：Mediators of inflammation

authors： Tamaoki J,Chiyotani A,Tagaya E,Isono K,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobility group box 1 (HMGB...

journal_title：Mediators of inflammation

authors： Jiang Y,Liu L,Curtiss E,Steinle JJ

更新日期：2017-01-01 00:00:00

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anae...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan F,Caglayan O,Basar M,Cakmak M,Batislam E,Ulusoy S

更新日期：2005-10-24 00:00:00

abstract：:Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...

journal_title：Mediators of inflammation

authors： Chung HJ,Koh W,Kim WK,Shin JS,Lee J,Lee SK,Ha IH

更新日期：2018-04-05 00:00:00

abstract：:There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning ...

journal_title：Mediators of inflammation

authors： León OS,Menéndez S,Merino N,Castillo R,Sam S,Pérez L,Cruz E,Bocci V

更新日期：1998-01-01 00:00:00

abstract：:The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the...

journal_title：Mediators of inflammation

authors： Focà A,Liberto MC,Quirino A,Marascio N,Zicca E,Pavia G

更新日期：2015-01-01 00:00:00

abstract：:This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...

journal_title：Mediators of inflammation

authors： Zhang D,Kuolee R,Harris G,Zhang Q,Conlan JW,Chen W

更新日期：2008-01-01 00:00:00

abstract：:The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92...

journal_title：Mediators of inflammation

authors： Moura TC,Amoras ED,Araújo MS,Freitas Queiroz MA,Conde SR,Demachki S,Martins-Feitosa RN,Machado LF,Cayres-Vallinoto IM,Ishak R,Vallinoto AC

更新日期：2017-01-01 00:00:00

abstract：:We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys admini...

journal_title：Mediators of inflammation

authors： Lomakin Y,Belogurov A Jr,Glagoleva I,Stepanov A,Zakharov K,Okunola J,Smirnov I,Genkin D,Gabibov A

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the presence of adipose tissue. Furthermore, we hypothesized that this au...

journal_title：Mediators of inflammation

authors： Pearson W,Garland AEN,Nixon A,Cant JP,Hurtig MB

更新日期：2020-11-12 00:00:00

abstract：:As a noninvasive method, exhaled breath condensate (EBC) has gained importance to improve monitoring of lung diseases and to detect biomarkers. The aim of the study was to investigate, whether erythropoietin (EPO) is detectable in EBC. EBC was collected from 22 consecutive patients as well as from healthy individuals....

journal_title：Mediators of inflammation

authors： Schumann C,Triantafilou K,Krueger S,Hombach V,Triantafilou M,Becher G,Lepper PM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on ...

journal_title：Mediators of inflammation

authors： Bodini A,Peroni DG,Zardini F,Corradi M,Alinovi R,Boner AL,Piacentini GL

更新日期：2006-01-01 00:00:00

abstract：:Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...

journal_title：Mediators of inflammation

authors： Ren JD,Ma J,Hou J,Xiao WJ,Jin WH,Wu J,Fan KH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS:We employed a chemiluminescence immunoas...

journal_title：Mediators of inflammation

authors： De Giglio L,Marinelli F,Prosperini L,Contessa GM,Gurreri F,Piattella MC,De Angelis F,Barletta VT,Tomassini V,Pantano P,Pozzilli C

更新日期：2015-01-01 00:00:00

abstract：:Thymosin beta(4) is a polypeptide isolated from thymosin fraction 5. This peptide exhibits important activities in the regulation and differentiation of thymus-dependent lymphocytes. An analogue of thymosin beta(4), [Phe(4F)(12)] deacetyl- thymosin beta(4), was synthesized by a solution method, followed by deprotectio...

journal_title：Mediators of inflammation

authors： Abiko T,Sekino H

更新日期：1992-01-01 00:00:00