Abstract:
:The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of follow-up, some patients showed "enticing" improvements on some exploratory efficacy measures, although a significant benefit was not observed for any measure across the entire group. Neither the progression of disability nor relapses were observed in any cases. In four patients, we found new gadolinium+ (Gd+) lesions on MRI. Our results indicate that ASC therapy is safe and does not produce any substantial side effects. Disease progression-free survival (PFS) of 18 months was seen in all patients with RRMS and SPMS. In these patients, EDSS scores did not progress above baseline scores. Gd-enhancing lesions were observed in two cases with RRMS, but these patients did not exhibit changes in EDSS score. Conclusion. Intrathecal treatment with ASCs is an attractive form of therapy for patients with MS but should be reserved for cases with aggressive disease progression, for cases that are still in the inflammatory phase, and for the malignant form.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Zdoi
10.1155/2016/5302120subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5302120eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
杂志文章abstract::Periploca forrestii Schltr. has been used as a Chinese folk medicine due to its versatile pharmacological effects such as promoting wounds and rheumatoid arthritis. However, the antiarthritic activity of Periploca forrestii saponin (PFS) and its active compound Periplocin has still not been demonstrated. Here, we eval...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7941684
更新日期:2016-01-01 00:00:00
abstract::The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the presence of adipose tissue. Furthermore, we hypothesized that this au...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8811001
更新日期:2020-11-12 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2120971
更新日期:2020-04-03 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/38210
更新日期:2007-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/785265
更新日期:2011-01-01 00:00:00
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journal_title:Mediators of inflammation
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更新日期:2015-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/9086758
更新日期:2019-07-10 00:00:00
abstract:AIM:This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. METHODS:BALB/c mice were infected intraperitoneally with a lethal challenge of Klebsiell...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/69431
更新日期:2006-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/715130
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2018/3809092.]. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,已发布勘误
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更新日期:2019-06-18 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350050024339
更新日期:2000-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/7570452
更新日期:2019-11-12 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/4981916
更新日期:2016-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5425346
更新日期:2018-10-21 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/767185
更新日期:2014-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/6769032
更新日期:2016-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.210
更新日期:2005-08-31 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6716419
更新日期:2017-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000518
更新日期:1996-01-01 00:00:00
abstract::Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4097574
更新日期:2016-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8467849
更新日期:2016-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
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