Abstract:
:Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal monocytes with ongoing proinflammatory cytokine release, could be associated with the progression of various inflammatory diseases in neonates. Our previous data indicate that amphiregulin (AREG) is increasingly expressed on the cell surface of neonatal monocytes, resulting in remarkably higher soluble AREG levels after proteolytic shedding. In this study, we found that E. coli-infected neonatal monocytes show an increased phosphorylation of ERK, increased expression of Bcl-2 and Bcl-XL, and reduced levels of cleaved caspase-3 and caspase-9 compared to adult monocytes. In both cell types, additional stimulation with soluble AREG further increased ERK activation and expression of Bcl-2 and Bcl-XL and reduced levels of cleaved caspase-3 and caspase-9 in an EGFR-dependent manner. These data suggest that reduced PICD of neonatal monocytes could be due to reduced intrinsic apoptosis and that AREG can promote protection against PICD. This reduction of the intrinsic apoptosis pathway in neonatal monocytes could be relevant for severely prolonged inflammatory responses of neonates.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Platen C,Dreschers S,Wappler J,Ludwig A,Düsterhöft S,Reiss LK,Orlikowsky TWdoi
10.1155/2019/1603131subject
Has Abstractpub_date
2019-11-03 00:00:00pages
1603131eissn
0962-9351issn
1466-1861journal_volume
2019pub_type
杂志文章abstract::In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/3064643
更新日期:2016-01-01 00:00:00
abstract::Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammator...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2021/8874339
更新日期:2021-01-14 00:00:00
abstract::The study monitored in vitro early response of connective tissue cells and immunocompetent cells to enosseal implant materials coated by different blood components (serum, activated plasma, and plasma/platelets) to evaluate human osteoblast proliferation and synthetic activity and inflammatory response presented as a ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8769347
更新日期:2016-01-01 00:00:00
abstract::To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation anal...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/5830361
更新日期:2016-01-01 00:00:00
abstract::Paraoxonase 1 (PON1) activity is markedly influenced by coding polymorphisms, Q/R at position 192 and M/L at position 55 of the PON1 gene. We investigated the frequencies of these polymorphisms and their effects on PON1 and antioxidant activities in 844 South African mixed ancestry individuals. Genotyping was done usi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/217019
更新日期:2014-01-01 00:00:00
abstract::We previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has been reported that this venom presents an important inflammatory effect when inoculated in animal mo...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935029000041
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY:To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD:The eff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350410001664798
更新日期:2004-02-01 00:00:00
abstract::Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Educa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/959281
更新日期:2009-01-01 00:00:00
abstract::Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/506450
更新日期:2014-01-01 00:00:00
abstract::Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anae...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.312
更新日期:2005-10-24 00:00:00
abstract::Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics me...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/469358
更新日期:2014-01-01 00:00:00
abstract::In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. The corticotropin-releasing hormone and glucocorticoids are cr...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/893521
更新日期:2013-01-01 00:00:00
abstract::The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are invo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/793505
更新日期:2013-01-01 00:00:00
abstract::Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000499
更新日期:1994-01-01 00:00:00
abstract::Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5649214
更新日期:2017-01-01 00:00:00
abstract::The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were examined in mice. BALB/c mice were sensitized by intraperitoneal ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/096293500411532
更新日期:2000-01-01 00:00:00
abstract::Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/682193
更新日期:2014-01-01 00:00:00
abstract::To elucidate the role of (1-->3)-beta-D-glucan in pulmonary aspergilloma, serum concentrations of (1-->3)-beta-D-glucan were measured repeatedly for as long as 10 months in eight patients. In four patients with inactive disease, concentrations of (1-->3)-beta-D-glucan were in the normal range.The concentrations of (1-...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359791631
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS:In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS:Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935031000097718
更新日期:2003-04-01 00:00:00
abstract::We investigated whether TNB alters colonic tissue levels of PAF at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene. Strain gauge transducers were sewn...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000032
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has be...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350220131944
更新日期:2002-04-01 00:00:00
abstract::Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/2650590
更新日期:2019-01-08 00:00:00
abstract::Alcohol-related disorders are one of the challenging current health problems with medical, social, and economic consequences. Endotoxemia, oxidative stress, and release of a variety of inflammatory molecules are established mediators in alcoholic liver injury (ALD). Probiotics like L. plantarum though were reported to...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/715130
更新日期:2014-01-01 00:00:00
abstract::This study tested the hypothesis that shock wave therapy (SW) enhances mitochondrial uptake into the lung epithelial and parenchymal cells to attenuate lung injury from acute respiratory distress syndrome (ARDS). ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed applicat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5425346
更新日期:2018-10-21 00:00:00
abstract::The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/354087
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8045161
更新日期:2017-01-01 00:00:00
abstract::Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calciu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/375427
更新日期:2015-01-01 00:00:00
abstract::Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signal...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/3858032
更新日期:2018-03-11 00:00:00
abstract:BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/691491
更新日期:2015-01-01 00:00:00
abstract::The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/390951
更新日期:2009-01-01 00:00:00