Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in vitro.

abstract：:The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...

journal_title：Mediators of inflammation

authors： Matsushita K,Takeoka M,Sagara J,Itano N,Kurose Y,Nakamura A,Taniguchi S

更新日期：2009-01-01 00:00:00

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:Although the initiating events of Crohn's disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn's disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this under...

journal_title：Mediators of inflammation

authors： van Montfrans C,Camoglio L,van Deventer SJ

更新日期：1998-01-01 00:00:00

abstract：:Silica inhalation can induce chronic lung inflammation and fibrosis. Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells. IL-17A, the typical Th17 cytokine, is reported in some inflammatory d...

journal_title：Mediators of inflammation

authors： Tang W,Liu F,Chen Y,Song L,Dai W,Li C,Weng D,Chen J

更新日期：2014-01-01 00:00:00

abstract：:The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradat...

journal_title：Mediators of inflammation

authors： Sipe JD,Martel-Pelletier J,Otterness IG,Pelletier JP

更新日期：1994-01-01 00:00:00

abstract：:Behçet's disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways. The objective of this study was to investigate the association of the DC stimulatory molecu...

journal_title：Mediators of inflammation

authors： Islam SMS,Byun HO,Choi B,Sohn S

更新日期：2019-09-09 00:00:00

abstract：Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...

journal_title：Mediators of inflammation

authors： Yu J,Liu H,He S,Li P,Ma C,Ma M,Liu Y,Lv L,Ping F,Zhang H,Li W,Sun Q,Xu L,Li Y

更新日期：2020-05-22 00:00:00

abstract：:The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...

journal_title：Mediators of inflammation

authors： Wang SW,Lin TM,Wang CH,Liu HH,Houng JY

更新日期：2012-01-01 00:00:00

abstract：:Alveolar macrophages have recently been postulated as being involved in the aetiology of adult respiratory distress syndrome (ARDS). To evaluate their role, basal cyclic AMP levels and responsiveness of adenylyl cyclase alveolar macrophages were determined at four intermediate stages of developing respiratory distress...

journal_title：Mediators of inflammation

authors： Amsterdam JG,Heijde RM,Grotjohan HP,Beusenberg FD

更新日期：1993-01-01 00:00:00

abstract：:Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...

journal_title：Mediators of inflammation

authors： Zhou YH,Yu JP,Liu YF,Teng XJ,Ming M,Lv P,An P,Liu SQ,Yu HG

更新日期：2006-01-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor used for hematologic cancer treatment. Since it can suppress NF-κB activation, which is critical for the inflammatory process, bortezomib has been found to possess anti-inflammatory activity. In this study, we evaluated the effect of bortezomib on experimental autoimmune uveitis (E...

journal_title：Mediators of inflammation

authors： Hsu SM,Yang CH,Shen FH,Chen SH,Lin CJ,Shieh CC

更新日期：2015-01-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of peptides derived from synbiotics on improving inflammatory bowel disease (IBD). Five-week-old male C57BL/6 mice were administered with dextran sulfate sodium (DSS) via drinking water for seven days to induce IBD (IBD group). The mice in the IBD group were oral...

journal_title：Mediators of inflammation

authors： Ha J,Oh H,Oh NS,Seo Y,Kang J,Park MH,Kim KS,Kang SH,Yoon Y

更新日期：2020-07-04 00:00:00

abstract：:Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...

journal_title：Mediators of inflammation

authors： Memmert S,Damanaki A,Nogueira AVB,Eick S,Nokhbehsaim M,Papadopoulou AK,Till A,Rath B,Jepsen S,Götz W,Piperi C,Basdra EK,Cirelli JA,Jäger A,Deschner J

更新日期：2017-01-01 00:00:00

abstract：:As a noninvasive method, exhaled breath condensate (EBC) has gained importance to improve monitoring of lung diseases and to detect biomarkers. The aim of the study was to investigate, whether erythropoietin (EPO) is detectable in EBC. EBC was collected from 22 consecutive patients as well as from healthy individuals....

journal_title：Mediators of inflammation

authors： Schumann C,Triantafilou K,Krueger S,Hombach V,Triantafilou M,Becher G,Lepper PM

更新日期：2006-01-01 00:00:00

abstract：:Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...

journal_title：Mediators of inflammation

authors： Bayer A,Lammel J,Tohidnezhad M,Lippross S,Behrendt P,Klüter T,Pufe T,Cremer J,Jahr H,Rademacher F,Gläser R,Harder J

更新日期：2017-01-01 00:00:00

abstract：:It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction. The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported. We hypothes...

journal_title：Mediators of inflammation

authors： He Y,Li Z,Zuo YX

更新日期：2015-01-01 00:00:00

abstract：:Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroi...

journal_title：Mediators of inflammation

authors： Traina G,Cataldi S,Siccu P,Loreti E,Ferri I,Sidoni A,Codini M,Gizzi C,Sichetti M,Ambesi-Impiombato FS,Beccari T,Curcio F,Albi E

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...

journal_title：Mediators of inflammation

authors： McKay S,Bromhaar MM,de Jongste JC,Hoogsteden HC,Saxena PR,Sharma HS

更新日期：2001-06-01 00:00:00

abstract：:Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...

journal_title：Mediators of inflammation

authors： Kazama I

更新日期：2015-01-01 00:00:00

abstract：:Invertebrates do not display the level of sophistication in immune reactivity characteristic of mammals and other 'higher' vertebrates. Their great number and diversity of forms, however, reflect their evolutionary success and hence they must have effective mechanisms of defence to deal with parasites and pathogens an...

journal_title：Mediators of inflammation

authors： Rowley AF

更新日期：1996-01-01 00:00:00

abstract：AIM:This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. METHODS:BALB/c mice were infected intraperitoneally with a lethal challenge of Klebsiell...

journal_title：Mediators of inflammation

authors： Rukavina T,Ticac B,Vasiljev V

更新日期：2006-01-01 00:00:00

abstract：Objective:To profile maternal plasma metabolome in spontaneous preterm birth. Method:In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy (n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy (n = 49)), and with t...

journal_title：Mediators of inflammation

authors： Lizewska B,Teul J,Kuc P,Lemancewicz A,Charkiewicz K,Goscik J,Kacerovsky M,Menon R,Miltyk W,Laudanski P

更新日期：2018-02-15 00:00:00

abstract：:BCG, the only registered vaccine against Mycobacterial Tuberculosis (TB) infection, has been questioned for its protective efficacy for decades. Although lots of efforts were made to improve the BCG antigenicity, few studies were devoted to understand the role of host factors in the variability of the BCG protection. ...

journal_title：Mediators of inflammation

authors： Xu H,Jia Y,Li Y,Wei C,Wang W,Guo R,Jia J,Wu Y,Li Z,Wei Z,Qi X,Li Y,Gao X

更新日期：2019-06-12 00:00:00

abstract：:Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...

journal_title：Mediators of inflammation

authors： Blancke F,Claeys MJ,Jorens P,Vermeiren G,Bosmans J,Wuyts FL,Vrints CJ

更新日期：2005-12-14 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2019/2056085.]. ...

journal_title：Mediators of inflammation

authors： Pacheco-Fernández T,Juárez-Avelar I,Illescas O,Terrazas LI,Hernández-Pando R,Pérez-Plasencia C,Gutiérrez-Cirlos EB,Ávila-Moreno F,Chirino YI,Reyes JL,Maldonado V,Rodriguez-Sosa M

更新日期：2020-06-17 00:00:00

abstract：Background:Gut barrier dysfunction with alterant mucosal permeability during sepsis is a challenge problem in clinical practice. Intestinal epithelial cells (IECs) are strongly involved in mucosal oxidative stress and inflammatory response. The current study aimed at investigating the effect of MitoQ, a mitochondrial t...

journal_title：Mediators of inflammation

authors： Zhang S,Zhou Q,Li Y,Zhang Y,Wu Y

更新日期：2020-04-11 00:00:00

abstract：:Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...

journal_title：Mediators of inflammation

authors： Sartori C,Lazzeroni P,Merli S,Patianna VD,Viaroli F,Cirillo F,Amarri S,Street ME

更新日期：2016-01-01 00:00:00

abstract：:Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensu...

journal_title：Mediators of inflammation

authors： Wang Y,Gu Y,Huang F,Liu D,Zhang Z,Zhou N,Liang J,Lu C,Yuan D,Hei Z

更新日期：2018-06-20 00:00:00

abstract：:Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...

journal_title：Mediators of inflammation

authors： Donate-Correa J,Domínguez-Pimentel V,Méndez-Pérez ML,Muros-de-Fuentes M,Mora-Fernández C,Martín-Núñez E,Cazaña-Pérez V,Navarro-González JF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. METHODS:Using a hapten (ethanol-dinitr...

journal_title：Mediators of inflammation

authors： Stanton MM,Nelson LK,Benediktsson H,Hollenberg MD,Buret AG,Ceri H

更新日期：2013-01-01 00:00:00