Abstract:
:Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroid microstructure and the possibility that molecules involved in thyroid function might be associated with structural changes. Results from this study indicate changes in the height of the thyrocytes and in the amplitude of interfollicular spaces, anomalous expression/localization of thyrotropin, thyrotropin receptor, and thyroglobulin aging. Thyrotropin and thyrotropin receptor are upregulated and are distributed inside the colloid while thyroglobulin fills the interfollicular spaces. In an approach aimed at defining the behavior of molecules that change in different physiopathological conditions of thyroid, such as galectin-3 and sphingomyelinase, we then wondered what was their behavior in the thyroid gland in aging. Importantly, in comparison with the thyroid of young animals, we have found a higher expression of galectin-3 and a delocalization of neutral sphingomyelinase in the thyroid of old animals. A possible relationship between galectin-3, neutral sphingomyelinase, and aging has been discussed.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Traina G,Cataldi S,Siccu P,Loreti E,Ferri I,Sidoni A,Codini M,Gizzi C,Sichetti M,Ambesi-Impiombato FS,Beccari T,Curcio F,Albi Edoi
10.1155/2017/8102170subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8102170eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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更新日期:2020-03-12 00:00:00
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journal_title:Mediators of inflammation
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Mediators of inflammation
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pub_type: 已发布勘误
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journal_title:Mediators of inflammation
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