Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb.

abstract：:The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...

journal_title：Mediators of inflammation

authors： Li XH,Gong X,Zhang L,Jiang R,Li HZ,Wu MJ,Wan JY

更新日期：2013-01-01 00:00:00

abstract：:Fibrosis of oesophagus, lungs, heart, and kidney in the course of systemic sclerosis (SSc) may lead to dysfunction of the above organs or even patients death. Recent studies point out the role of angiogenesis and fibrosis disturbances in the pathogenesis of SSc. Heart fibrosis is one of the most important prognostic f...

journal_title：Mediators of inflammation

authors： Dziankowska-Bartkowiak B,Waszczykowska E,Zalewska A,Sysa-Jedrzejowska A

更新日期：2005-08-14 00:00:00

abstract：:The objective of this study was to evaluate the effects of peptides derived from synbiotics on improving inflammatory bowel disease (IBD). Five-week-old male C57BL/6 mice were administered with dextran sulfate sodium (DSS) via drinking water for seven days to induce IBD (IBD group). The mice in the IBD group were oral...

journal_title：Mediators of inflammation

authors： Ha J,Oh H,Oh NS,Seo Y,Kang J,Park MH,Kim KS,Kang SH,Yoon Y

更新日期：2020-07-04 00:00:00

abstract：:It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...

journal_title：Mediators of inflammation

authors： Poulain-Godefroy O,Le Bacquer O,Plancq P,Lecoeur C,Pattou F,Frühbeck G,Froguel P

更新日期：2010-01-01 00:00:00

abstract：:OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...

journal_title：Mediators of inflammation

authors： Roayaie S,Sheiner PA,Emre S,Guy S,Schwartz ME,Boros P,Miller CM

更新日期：2000-01-01 00:00:00

abstract：:Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individ...

journal_title：Mediators of inflammation

authors： Posadas-Sánchez R,Pérez-Hernández N,Angeles-Martínez J,López-Bautista F,Villarreal-Molina T,Rodríguez-Pérez JM,Fragoso JM,Posadas-Romero C,Vargas-Alarcón G

更新日期：2017-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased l...

journal_title：Mediators of inflammation

authors： Nokhbehsaim M,Keser S,Jäger A,Jepsen S,Deschner J

更新日期：2013-01-01 00:00:00

abstract：:Aim. Inflammation is important in heart failure (HF). The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF. We investigated the role of TLR9 in a murine diastolic HF model caused by cardiomyocyte SERCA2a excision. Methods and Results. We crossed SERCA...

journal_title：Mediators of inflammation

authors： Dhondup Y,Sjaastad I,Sandanger Ø,Aronsen JM,Ahmed MS,Attramadal H,Finsen AV,Zhang L,Ranheim T,Alfsnes K,Aukrust P,Christensen G,Yndestad A,Vinge LE

更新日期：2017-01-01 00:00:00

abstract：:Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...

journal_title：Mediators of inflammation

authors： Costantini E,D'Angelo C,Reale M

更新日期：2018-03-08 00:00:00

abstract：:Type 2 Diabetes Mellitus (T2DM) is well known to include an inflammatory component that has been considered to be related to diabetic complications. Diabetic nephropathy (DN) is one of the significant complications as it constitutes the most frequent cause of end-stage renal disease. Tumor Necrosis Factor-α (TNF-α) is...

journal_title：Mediators of inflammation

authors： Emara M,El-Edel R,Fathy WM,Aboelkhair NT,Watany MM,Abou-Elela DH

更新日期：2020-07-01 00:00:00

abstract：:Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the regulation of the ant...

journal_title：Mediators of inflammation

authors： Makeeva A,Rodriguez-Montesinos J,Zelenikhin P,Nesmelov A,Preissner KT,Cabrera-Fuentes HA,Ilinskaya ON

更新日期：2017-01-01 00:00:00

abstract：:The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are invo...

journal_title：Mediators of inflammation

authors： Pniewska E,Pawliczak R

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2019/2056085.]. ...

journal_title：Mediators of inflammation

authors： Pacheco-Fernández T,Juárez-Avelar I,Illescas O,Terrazas LI,Hernández-Pando R,Pérez-Plasencia C,Gutiérrez-Cirlos EB,Ávila-Moreno F,Chirino YI,Reyes JL,Maldonado V,Rodriguez-Sosa M

更新日期：2020-06-17 00:00:00

abstract：:Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...

journal_title：Mediators of inflammation

authors： Bao N,Dai D

更新日期：2020-04-03 00:00:00

abstract：:Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...

journal_title：Mediators of inflammation

authors： Lehmann C,Islam S,Jarosch S,Zhou J,Hoskin D,Greenshields A,Al-Banna N,Sharawy N,Sczcesniak A,Kelly M,Wafa K,Cheliak W,Holbein B

更新日期：2015-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...

journal_title：Mediators of inflammation

authors： Zhang D,Kuolee R,Harris G,Zhang Q,Conlan JW,Chen W

更新日期：2008-01-01 00:00:00

abstract：:Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...

journal_title：Mediators of inflammation

authors： Bronisz E,Kurkowska-Jastrzębska I

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...

journal_title：Mediators of inflammation

authors： Noguchi T,Sado T,Naruse K,Shigetomi H,Onogi A,Haruta S,Kawaguchi R,Nagai A,Tanase Y,Yoshida S,Kitanaka T,Oi H,Kobayashi H

更新日期：2010-01-01 00:00:00

abstract：:Long-term exposure to crystalline silica leads to silicosis, which is characterized by persistent lung inflammation and lung fibrosis. Multiple immune cells have been demonstrated to participate in crystalline silica-induced immune responses. Our previous study indicated that B10 could control lung inflammation throug...

journal_title：Mediators of inflammation

authors： Lu Y,Liu F,Li C,Chen Y,Weng D,Chen J

更新日期：2017-01-01 00:00:00

abstract：:Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF-...

journal_title：Mediators of inflammation

authors： Zarzynska JM

更新日期：2014-01-01 00:00:00

abstract：:Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems and in conditions of neuropa...

journal_title：Mediators of inflammation

authors： Ramesh G,MacLean AG,Philipp MT

更新日期：2013-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with other cytokines. However, exorbitant or ...

journal_title：Mediators of inflammation

authors： Dirisala VR,Jeevan A,Ly LH,McMurray DN

更新日期：2015-01-01 00:00:00

abstract：:The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-deri...

journal_title：Mediators of inflammation

authors： Alvarez Y,Valera I,Municio C,Hugo E,Padrón F,Blanco L,Rodríguez M,Fernández N,Crespo MS

更新日期：2010-01-01 00:00:00

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...

journal_title：Mediators of inflammation

authors： Passos BN,Lima MC,Sierra APR,Oliveira RA,Maciel JFS,Manoel R,Rogante JI,Pesquero JB,Cury-Boaventura MF

更新日期：2019-10-07 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display signi...

journal_title：Mediators of inflammation

authors： Yin G,Wang Y,Cen XM,Yang M,Liang Y,Xie QB

更新日期：2015-01-01 00:00:00

abstract：:Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...

journal_title：Mediators of inflammation

authors： Zhang L,Haddouti EM,Beckert H,Biehl R,Pariyar S,Rüwald JM,Li X,Jaenisch M,Burger C,Wirtz DC,Kabir K,Schildberg FA

更新日期：2020-12-03 00:00:00

abstract：:Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...

journal_title：Mediators of inflammation

authors： Wang W,Xu D,Wang B,Yan S,Wang X,Yin Y,Wang X,Sun B,Sun X

更新日期：2015-01-01 00:00:00

abstract：:Procalcitonin (PCT) is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested ...

journal_title：Mediators of inflammation

authors： Rami D,La Bianca M,Agostinis C,Zauli G,Radillo O,Bulla R

更新日期：2014-01-01 00:00:00