Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development.

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expresse...

journal_title：Mediators of inflammation

authors： Deng Y,Yang L,Xie Q,Yang F,Li G,Zhang G,Li S,Wu Z,Wang J,Kang X

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:The proinflammatory chemokine CXCL10, in addition to its chemotactic properties, is also involved in the stimulation of natural killer and T-cell migration in Mycobacterium tuberculosis infection. In this study, our experiments were designed to determine the role of interferon (IFN)-alphabeta in the producti...

journal_title：Mediators of inflammation

authors： Méndez Samperio P,Trejo A,Miranda E

更新日期：2004-12-01 00:00:00

abstract：:Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine protei...

journal_title：Mediators of inflammation

authors： Yang H,Li T,Wei J,Zhang H,He S

更新日期：2013-01-01 00:00:00

abstract：:Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 pa...

journal_title：Mediators of inflammation

authors： Denizot Y,Fixe P,Cornu E,Nathan N

更新日期：1996-01-01 00:00:00

abstract：:The alteration of resting tension (RT) from 0.5 g to 2.5 g increased significantly airway smooth muscle contractions induced by acetylcholine (ACh) in rabbit trachea. The decrease in extracellular calcium concentration [Ca2+]o from 2 mM to 0.2 mM reduced ACh-induced contractions only at 2.5 g RT with no effect at 0.5 ...

journal_title：Mediators of inflammation

authors： Kitsiopoulou E,Hatziefthimiou AA,Gourgoulianis KI,Molyvdas PA

更新日期：2007-01-01 00:00:00

abstract：:Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through an...

journal_title：Mediators of inflammation

authors： Huang WC,Liou CJ,Shen SC,Hu S,Hsiao CY,Wu SJ

更新日期：2020-10-16 00:00:00

abstract：INTRODUCTION:Proliferative vitreoretinopathy (PVR) is a severe inflammatory complication of retinal detachment. Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases. We evaluated the expression of VEGF-A, Otx1, Otx2, Otx3, and p53 family member...

journal_title：Mediators of inflammation

authors： Azzolini C,Pagani IS,Pirrone C,Borroni D,Donati S,Al Oum M,Pigni D,Chiaravalli AM,Vinciguerra R,Simonelli F,Porta G

更新日期：2013-01-01 00:00:00

abstract：Objective:To profile maternal plasma metabolome in spontaneous preterm birth. Method:In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy (n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy (n = 49)), and with t...

journal_title：Mediators of inflammation

authors： Lizewska B,Teul J,Kuc P,Lemancewicz A,Charkiewicz K,Goscik J,Kacerovsky M,Menon R,Miltyk W,Laudanski P

更新日期：2018-02-15 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

journal_title：Mediators of inflammation

authors： Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

更新日期：2011-01-01 00:00:00

abstract：:To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...

journal_title：Mediators of inflammation

authors： Martini M,Dobrowolny G,Aucello M,Musarò A

更新日期：2015-01-01 00:00:00

abstract：:Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors. The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice. Mice were pretreated with OA-NO...

journal_title：Mediators of inflammation

authors： Wang H,Jia Z,Sun J,Xu L,Zhao B,Yu K,Yang M,Yang T,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorde...

journal_title：Mediators of inflammation

authors： Zhang H,Wu LM,Wu J

更新日期：2011-01-01 00:00:00

abstract：:Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...

journal_title：Mediators of inflammation

authors： van den Oever IA,Raterman HG,Nurmohamed MT,Simsek S

更新日期：2010-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are multifactorial disorders resulting from environmental and genetic factors. Polymorphisms in MDR1 and GSTs genes might explain individual differences in susceptibility to IBD. We carried out a case-control study to examine the association of MDR1 (C1236T and C3435T), GSTT1, and GST...

journal_title：Mediators of inflammation

authors： Senhaji N,Kassogue Y,Fahimi M,Serbati N,Badre W,Nadifi S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS:We employed a chemiluminescence immunoas...

journal_title：Mediators of inflammation

authors： De Giglio L,Marinelli F,Prosperini L,Contessa GM,Gurreri F,Piattella MC,De Angelis F,Barletta VT,Tomassini V,Pantano P,Pozzilli C

更新日期：2015-01-01 00:00:00

abstract：:Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. Previously, we have found that exosome-encapsulated miR-6803-5p is increa...

journal_title：Mediators of inflammation

authors： Yan S,Cheng M,Duan Q,Wang Z,Gao W,Ren B,Xu D

更新日期：2019-11-20 00:00:00

abstract：Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...

journal_title：Mediators of inflammation

authors： Talmac AC,Calisir M,Eroglu EG,Ertugrul AS

更新日期：2019-06-12 00:00:00

abstract：:Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...

journal_title：Mediators of inflammation

authors： Donate-Correa J,Domínguez-Pimentel V,Méndez-Pérez ML,Muros-de-Fuentes M,Mora-Fernández C,Martín-Núñez E,Cazaña-Pérez V,Navarro-González JF

更新日期：2014-01-01 00:00:00

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

journal_title：Mediators of inflammation

authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

更新日期：2016-01-01 00:00:00

abstract：:In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the ...

journal_title：Mediators of inflammation

authors： Post MJ,Biesebeek JD,Wemer J,Rooij HH,Zijlstra FJ,Porsius AJ

更新日期：1992-01-01 00:00:00

abstract：:Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for ...

journal_title：Mediators of inflammation

authors： Lopes MF,Costa-da-Silva AC,DosReis GA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Influenza virus is a worldwide health problem with significant economic consequences. To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study. AIMS:To assess...

journal_title：Mediators of inflammation

authors： Sakai S,Mantani N,Kogure T,Ochiai H,Shimada Y,Terasawa K

更新日期：2002-12-01 00:00:00

abstract：:Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...

journal_title：Mediators of inflammation

authors： Park S,Park NY,Valacchi G,Lim Y

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. METHODS AND SUBJECTS:A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) ...

journal_title：Mediators of inflammation

authors： Samocha-Bonet D,Justo D,Rogowski O,Saar N,Abu-Abeid S,Shenkerman G,Shapira I,Berliner S,Tomer A

更新日期：2008-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activ...

journal_title：Mediators of inflammation

authors： Sun Y,Shang D

更新日期：2015-01-01 00:00:00

abstract：:Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...

journal_title：Mediators of inflammation

authors： Piazza S,Pacchetti B,Fumagalli M,Bonacina F,Dell'Agli M,Sangiovanni E

更新日期：2019-06-25 00:00:00

abstract：:Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...

journal_title：Mediators of inflammation

authors： Vodo S,Bechi N,Petroni A,Muscoli C,Aloisi AM

更新日期：2013-01-01 00:00:00

abstract：:This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, a...

journal_title：Mediators of inflammation

authors： Zhou PH,Hu W,Zhang XB,Wang W,Zhang LJ

更新日期：2016-01-01 00:00:00