Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.

abstract：:Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintena...

journal_title：Mediators of inflammation

authors： Sykes L,MacIntyre DA,Yap XJ,Teoh TG,Bennett PR

更新日期：2012-01-01 00:00:00

abstract：:It has been suggested that the supernatant of LPSstimulated macrophages (macrophage nociceptive factor, MNF) promotes nociception in mice. Intraperitoneal administration of MNF induced dose-related writhing, which reached a plateau between 18 and 26 min after injection and decreased within 60 min. The release of MNF w...

journal_title：Mediators of inflammation

authors： Thomazzi SM,Ribeiro RA,Campos DI,Cunha FQ,Ferreira SH

更新日期：1997-01-01 00:00:00

abstract：:We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...

journal_title：Mediators of inflammation

authors： Cho CW,Ahn S,Lim TG,Hong HD,Rhee YK,Yang DC,Jang M

更新日期：2017-01-01 00:00:00

abstract：:Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition....

journal_title：Mediators of inflammation

authors： Correa-Costa M,Braga TT,Felizardo RJ,Andrade-Oliveira V,Perez KR,Cuccovia IM,Hiyane MI,da Silva JS,Câmara NO

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...

journal_title：Mediators of inflammation

authors： Wei CC,Ping DQ,You FT,Qiang CY,Tao C

更新日期：2016-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into ...

journal_title：Mediators of inflammation

authors： Parisi C,Napoli G,Pelegrin P,Volonté C

更新日期：2016-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...

journal_title：Mediators of inflammation

authors： Sedda S,Marafini I,Figliuzzi MM,Pallone F,Monteleone G

更新日期：2014-01-01 00:00:00

abstract：:The probiotic Enterococcus faecium HDRsEf1 (Ef1) has been shown to have positive effects on piglet diarrhoea, but the mechanism has not yet been elucidated. In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal p...

journal_title：Mediators of inflammation

authors： Tian Z,Liu X,Dai R,Xiao Y,Wang X,Bi D,Shi D

更新日期：2016-01-01 00:00:00

abstract：:Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...

journal_title：Mediators of inflammation

authors： Chai Y,Yu R,Liu Y,Wang S,Yuan D,Chen J

更新日期：2020-02-10 00:00:00

abstract：:The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and is the first line of defense against chemical and/or bacterial insult. Peritonitis remains a major complication of PD and is a predominant cause ...

journal_title：Mediators of inflammation

authors： Yung S,Chan TM

更新日期：2012-01-01 00:00:00

abstract：:Both alveolar macrophages (AMs) and alveolar epithelial cells (AECs) are main targets of Mycobacterium tuberculosis (M. tuberculosis (Mtb)). Intercellular communications between mucosal AECs and AMs have important implications in cellular responses to exogenous insults. However, molecular mechanisms underpinning inter...

journal_title：Mediators of inflammation

authors： Yang Y,Sun Y,Xu J,Bao K,Luo M,Liu X,Wang Y

更新日期：2018-09-26 00:00:00

abstract：:Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal mon...

journal_title：Mediators of inflammation

authors： Platen C,Dreschers S,Wappler J,Ludwig A,Düsterhöft S,Reiss LK,Orlikowsky TW

更新日期：2019-11-03 00:00:00

abstract：:In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during...

journal_title：Mediators of inflammation

authors： Hernández Cruz A,Barbosa Navarro L,Mendonça RZ,Petricevich VL

更新日期：2011-01-01 00:00:00

abstract：:Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobility group box 1 (HMGB...

journal_title：Mediators of inflammation

authors： Jiang Y,Liu L,Curtiss E,Steinle JJ

更新日期：2017-01-01 00:00:00

abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

journal_title：Mediators of inflammation

authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

更新日期：1993-01-01 00:00:00

abstract：:Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study the effects of trea...

journal_title：Mediators of inflammation

authors： Misdaq M,Ziegler S,von Ahsen N,Oellerich M,Asif AR

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

journal_title：Mediators of inflammation

authors： Bajnok A,Ivanova M,Rigó J Jr,Toldi G

更新日期：2017-01-01 00:00:00

abstract：:The study monitored in vitro early response of connective tissue cells and immunocompetent cells to enosseal implant materials coated by different blood components (serum, activated plasma, and plasma/platelets) to evaluate human osteoblast proliferation and synthetic activity and inflammatory response presented as a ...

journal_title：Mediators of inflammation

authors： Himmlova L,Kubies D,Hulejova H,Bartova J,Riedel T,Stikarova J,Suttnar J,Pesakova V

更新日期：2016-01-01 00:00:00

abstract：:Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...

journal_title：Mediators of inflammation

authors： Branco ACCC,Yoshikawa FSY,Pietrobon AJ,Sato MN

更新日期：2018-08-27 00:00:00

abstract：:Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...

journal_title：Mediators of inflammation

authors： Cheng YL,Lin YS,Chen CL,Wan SW,Ou YD,Yu CY,Tsai TT,Tseng PC,Lin CF

更新日期：2015-01-01 00:00:00

abstract：:Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...

journal_title：Mediators of inflammation

authors： Baptista FI,Aveleira CA,Castilho ÁF,Ambrósio AF

更新日期：2017-01-01 00:00:00

abstract：:The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two cytokines--transforming growth fact...

journal_title：Mediators of inflammation

authors： Su WH,Cheng MH,Lee WL,Tsou TS,Chang WH,Chen CS,Wang PH

更新日期：2010-01-01 00:00:00

abstract：:Aim. Inflammation is important in heart failure (HF). The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF. We investigated the role of TLR9 in a murine diastolic HF model caused by cardiomyocyte SERCA2a excision. Methods and Results. We crossed SERCA...

journal_title：Mediators of inflammation

authors： Dhondup Y,Sjaastad I,Sandanger Ø,Aronsen JM,Ahmed MS,Attramadal H,Finsen AV,Zhang L,Ranheim T,Alfsnes K,Aukrust P,Christensen G,Yndestad A,Vinge LE

更新日期：2017-01-01 00:00:00

abstract：AIM:This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. METHODS:BALB/c mice were infected intraperitoneally with a lethal challenge of Klebsiell...

journal_title：Mediators of inflammation

authors： Rukavina T,Ticac B,Vasiljev V

更新日期：2006-01-01 00:00:00

abstract：:Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...

journal_title：Mediators of inflammation

authors： Sartori C,Lazzeroni P,Merli S,Patianna VD,Viaroli F,Cirillo F,Amarri S,Street ME

更新日期：2016-01-01 00:00:00

abstract：:OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...

journal_title：Mediators of inflammation

authors： Roayaie S,Sheiner PA,Emre S,Guy S,Schwartz ME,Boros P,Miller CM

更新日期：2000-01-01 00:00:00

abstract：:Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...

journal_title：Mediators of inflammation

authors： De Cunto G,Lamberti A,de Santi MM,Miracco C,Fimiani M,Lungarella G,Cavarra E

更新日期：2017-01-01 00:00:00

abstract：:[This retracts the article DOI: 10.1155/2018/4514329.]. ...

journal_title：Mediators of inflammation

authors： Of Inflammation M

更新日期：2020-09-29 00:00:00

abstract：:Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune disease...

journal_title：Mediators of inflammation

authors： Yen JH,Chang CM,Hsu YW,Lee CH,Wu MS,Hwang DY,Chen BK,Liao HT,Wu MT,Chang WC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....

journal_title：Mediators of inflammation

authors： Liu Y,Liu T,Wu J,Li T,Jiao X,Zhang H,Zhao J,Wang J,Liu L,Cao L,Li S,Xu J,Xu J,Ma X,Yang L,Dong L

更新日期：2017-01-01 00:00:00