Abstract:
INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking. The characteristics of cellular adhesion molecules in preeclampsia are yet to be described. MATERIAL AND METHODS:Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins. RESULTS:We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy. No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes. CONCLUSIONS:Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Bajnok A,Ivanova M,Rigó J Jr,Toldi Gdoi
10.1155/2017/8045161subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8045161eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章abstract::Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/2650590
更新日期:2019-01-08 00:00:00
abstract::Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chronic kidney diseases. Prolonged injurious stimuli and chronic inflammati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5103672
更新日期:2018-10-14 00:00:00
abstract:UNLABELLED:The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children. METHODS:A cross-sectional study was performed in 180 steroid dependent atopic children...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/49240
更新日期:2007-01-01 00:00:00
abstract::Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory pro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/942159
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND AIM:Immunization with live virus vaccines may cause an immunosuppression with lymphopaenia, impaired cytokine production and defective lymphocyte response to mitogenes. These abnormalities were described in subjects vaccinated against measles. This study was performed to analyse the host immune response ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350310001599639
更新日期:2003-08-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2018/4514329.]. ...
journal_title:Mediators of inflammation
pub_type: 撤回出版物
doi:10.1155/2020/7859157
更新日期:2020-09-29 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/2056085.]. ...
journal_title:Mediators of inflammation
pub_type: 已发布勘误
doi:10.1155/2020/2195341
更新日期:2020-06-17 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2985051
更新日期:2017-01-01 00:00:00
abstract::Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/516740
更新日期:2015-01-01 00:00:00
abstract::The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/690525
更新日期:2012-01-01 00:00:00
abstract::Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6573802
更新日期:2017-01-01 00:00:00
abstract::Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identificati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/1851420
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09511920410001713510
更新日期:2004-06-01 00:00:00
abstract::Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/9213074
更新日期:2019-04-17 00:00:00
abstract::The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8360936
更新日期:2020-08-21 00:00:00
abstract::Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/5628404
更新日期:2016-01-01 00:00:00
abstract::Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/803095
更新日期:2014-01-01 00:00:00
abstract::Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8172706
更新日期:2016-01-01 00:00:00
abstract::Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/432785
更新日期:2014-01-01 00:00:00
abstract::Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and pu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2309175
更新日期:2019-01-16 00:00:00
abstract::Cardiovascular disease linked to atherosclerosis is the leading cause of death worldwide. Atherosclerosis is mainly linked to dysfunction in vascular endothelial cells and subendothelial accumulation of oxidized forms of LDL. In the present study, we investigated the role of myeloperoxidase oxidized LDL (Mox-LDL) in e...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/134635
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans. In this study, we investigated the influence of cardiovascular risk factors on the expression of the PGE2 pathway in human AAA...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/316150
更新日期:2014-01-01 00:00:00
abstract::Behçet's disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways. The objective of this study was to investigate the association of the DC stimulatory molecu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/5761392
更新日期:2019-09-09 00:00:00
abstract::Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7369020
更新日期:2016-01-01 00:00:00
abstract::Paraoxonase 1 (PON1) activity is markedly influenced by coding polymorphisms, Q/R at position 192 and M/L at position 55 of the PON1 gene. We investigated the frequencies of these polymorphisms and their effects on PON1 and antioxidant activities in 844 South African mixed ancestry individuals. Genotyping was done usi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/217019
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/958403
更新日期:2010-01-01 00:00:00
abstract::High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA IgG antibodies from patients with ty...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/196297
更新日期:2015-01-01 00:00:00
abstract::Systemic sclerosis (SSc) is an autoimmune connective tissue disorder of unknown etiology. This disease is characterized by a large variety of clinical patterns, which include the fibrosis of skin and visceral organs causing a variety of clinical manifestations. Genetic and environmental factors participate in the etio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/389582
更新日期:2014-01-01 00:00:00
abstract:Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4798209
更新日期:2018-06-28 00:00:00
abstract::The probiotic Enterococcus faecium HDRsEf1 (Ef1) has been shown to have positive effects on piglet diarrhoea, but the mechanism has not yet been elucidated. In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal p...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7474306
更新日期:2016-01-01 00:00:00