The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia.

Abstract:

INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking. The characteristics of cellular adhesion molecules in preeclampsia are yet to be described. MATERIAL AND METHODS:Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins. RESULTS:We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy. No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes. CONCLUSIONS:Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia.

journal_name

Mediators Inflamm

authors

Bajnok A,Ivanova M,Rigó J Jr,Toldi G

doi

10.1155/2017/8045161

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

8045161

eissn

0962-9351

issn

1466-1861

journal_volume

2017

pub_type

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