Abstract:
:Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identification of its roles in regulating cellular homeostatic processes, ranging from cellular bioenergetics to apoptosis. MAM provides an excellent platform for numerous signaling pathways; among them, inflammatory signaling pathways associated with MAM play a critical role in cellular defense during pathogenic infections and metabolic disorders. However, induction of MAM causes deleterious effects by amplifying mitochondrial reactive oxygen species generation through increased calcium transfer from the ER to mitochondria, thereby causing mitochondrial damage and release of mitochondrial components into the cytosol as damage-associated molecular patterns (DAMPs). These mitochondrial DAMPs rapidly activate MAM-resident inflammasome components and other inflammatory factors, which promote inflammasome complex formation and release of proinflammatory cytokines in pathological conditions. Long-term stimulation of the inflammasome instigates chronic inflammation, leading to the pathogenesis of metabolic diseases. In this review, we summarize the current understanding of MAM and its association with inflammation-mediated metabolic diseases.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Thoudam T,Jeon JH,Ha CM,Lee IKdoi
10.1155/2016/1851420subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1851420eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
杂志文章,评审abstract::Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/984643
更新日期:2012-01-01 00:00:00
abstract::Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/912595
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abstract::Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/recept...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/486758
更新日期:2015-01-01 00:00:00
abstract::Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for...
journal_title:Mediators of inflammation
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abstract::OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...
journal_title:Mediators of inflammation
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doi:10.1080/09629350020002877
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abstract::Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/145293
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8102170
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4097574
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abstract:BACKGROUND:Influenza virus is a worldwide health problem with significant economic consequences. To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study. AIMS:To assess...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935021000051557
更新日期:2002-12-01 00:00:00
abstract::The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and is the first line of defense against chemical and/or bacterial insult. Peritonitis remains a major complication of PD and is a predominant cause ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/484167
更新日期:2012-01-01 00:00:00
abstract::Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple cytokines. Although dysregulation of interleukin- (IL-) 22 is invol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/209179
更新日期:2013-01-01 00:00:00
abstract::The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two cytokines--transforming growth fact...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/413238
更新日期:2010-01-01 00:00:00
abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/239740
更新日期:2008-01-01 00:00:00
abstract::This study investigated the protective effects of intravitreal Resolvin D1 (RvD1) against LPS-induced rat endotoxic uveitis (EIU). RvD1 was administered into the right eye at a single injection of 5 μL volume containing 10-100-1000 ng/kg RvD1 1 h post-LPS injection (200 μg, Salmonella minnesota) into thefootpad of Spr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/149381
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. METHODS:Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/407972
更新日期:2008-01-01 00:00:00
abstract::Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/528568
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases. OBJECTIVE:To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/708608
更新日期:2014-01-01 00:00:00
abstract::Edelweiss (Leontopodium alpinum Cass.) is traditionally employed in folk medicine as an anti-inflammatory remedy. In nature, the plant is sparsely available and protected; therefore production of callus cultures was established. A concentrated ethanolic extract of culture homogenate, with leontopodic acid representing...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/498373
更新日期:2012-01-01 00:00:00
abstract::Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3824593
更新日期:2020-12-03 00:00:00
abstract::BCG, the only registered vaccine against Mycobacterial Tuberculosis (TB) infection, has been questioned for its protective efficacy for decades. Although lots of efforts were made to improve the BCG antigenicity, few studies were devoted to understand the role of host factors in the variability of the BCG protection. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/8616154
更新日期:2019-06-12 00:00:00
abstract::Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5649214
更新日期:2017-01-01 00:00:00
abstract::Incubation of rat hepatocytes in primary culture with IL-1beta at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (-35%) in the amount of apoE mRNA, but increased apoE synthesi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000498
更新日期:1992-01-01 00:00:00
abstract::Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/386148
更新日期:2014-01-01 00:00:00
abstract::Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/3541283
更新日期:2016-01-01 00:00:00
abstract::The causes of retinal hypoxia are many and varied. Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines. Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biologica...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/935301
更新日期:2013-01-01 00:00:00
abstract::Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137 signaling activation was activated by agonis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1382805
更新日期:2017-01-01 00:00:00
abstract::Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2432958
更新日期:2017-01-01 00:00:00
abstract:Background:Multiple sclerosis (MS) is a chronic debilitating disorder characterized by persisting damage to the brain caused by autoreactive leukocytes. Leukocyte activation is regulated by cytokines, which are readily detected in MS serum and cerebrospinal fluid (CSF). Objective:Serum and CSF levels of forty-five cyt...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2727042
更新日期:2020-10-22 00:00:00
abstract::Colitis is a major form of inflammatory bowel disease which involved mucosal immune dysfunction. Aloperine is an alkaloid isolated from the shrub Sophora alopecuroides L. and has been recognized as an effective treatment for inflammatory and allergic diseases. The present study aimed to examine the molecular mechanism...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5706152
更新日期:2017-01-01 00:00:00
abstract::Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.385
更新日期:2005-12-14 00:00:00