Myeloperoxidase oxidized LDL interferes with endothelial cell motility through miR-22 and heme oxygenase 1 induction: possible involvement in reendothelialization of vascular injuries.

abstract：:Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased dono...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Spranz D,Schemmer P,Bruckner T,Uhle F,Martin EO,Weigand MA,Hofer S

更新日期：2013-01-01 00:00:00

abstract：:Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 +/...

journal_title：Mediators of inflammation

authors： Taquet N,Dumont S,Vonesch JL,Hentsch D,Reimund JM,Muller CD

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...

journal_title：Mediators of inflammation

authors： Sainaghi PP,Collimedaglia L,Alciato F,Molinari R,Sola D,Ranza E,Naldi P,Monaco F,Leone M,Pirisi M,Avanzi GC

更新日期：2013-01-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions. SUBJECTS AND METHODS:Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a...

journal_title：Mediators of inflammation

authors： Prso IB,Kocjan W,Simić H,Brumini G,Pezelj-Ribarić S,Borcić J,Ferreri S,Karlović IM

更新日期：2007-01-01 00:00:00

abstract：Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...

journal_title：Mediators of inflammation

authors： Hou J,Zhang M,Ding Y,Wang X,Li T,Gao P,Jiang Y

更新日期：2018-06-21 00:00:00

abstract：:Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and neurodegeneration. During angiogenesis and vascular remodeling, behaviors of stem/progenitor cells, endothelial cells (ECs), and vascular smooth mus...

journal_title：Mediators of inflammation

authors： Chen Q,Jin M,Yang F,Zhu J,Xiao Q,Zhang L

更新日期：2013-01-01 00:00:00

abstract：:To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation anal...

journal_title：Mediators of inflammation

authors： Ko YL,Hsu LA,Wu S,Teng MS,Chou HH

更新日期：2016-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...

journal_title：Mediators of inflammation

authors： Tortarolo M,Lo Coco D,Veglianese P,Vallarola A,Giordana MT,Marcon G,Beghi E,Poloni M,Strong MJ,Iyer AM,Aronica E,Bendotti C

更新日期：2017-01-01 00:00:00

abstract：Background:Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods:Fifty Sprague...

journal_title：Mediators of inflammation

authors： Wang L,Chen F,Pan Y,Lin L,Xiong X

更新日期：2017-01-01 00:00:00

abstract：:Both alveolar macrophages (AMs) and alveolar epithelial cells (AECs) are main targets of Mycobacterium tuberculosis (M. tuberculosis (Mtb)). Intercellular communications between mucosal AECs and AMs have important implications in cellular responses to exogenous insults. However, molecular mechanisms underpinning inter...

journal_title：Mediators of inflammation

authors： Yang Y,Sun Y,Xu J,Bao K,Luo M,Liu X,Wang Y

更新日期：2018-09-26 00:00:00

abstract：:Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...

journal_title：Mediators of inflammation

authors： Blancke F,Claeys MJ,Jorens P,Vermeiren G,Bosmans J,Wuyts FL,Vrints CJ

更新日期：2005-12-14 00:00:00

abstract：:Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...

journal_title：Mediators of inflammation

authors： Korniluk A,Koper-Lenkiewicz OM,Kamińska J,Kemona H,Dymicka-Piekarska V

更新日期：2019-04-17 00:00:00

abstract：:The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammato...

journal_title：Mediators of inflammation

authors： Fuentes E,Fuentes F,Vilahur G,Badimon L,Palomo I

更新日期：2013-01-01 00:00:00

abstract：:The role of eosinophils in inflammation and their mode of activation is not well understood. Eosinophil accumulation and subsequent expression of cytokines at the site of inflammation may play a role in exacerbation of inflammatory responses. In the present study, we have examined the role of TNF-alpha in eosinophil a...

journal_title：Mediators of inflammation

authors： Goldstein LA,Strieter RM,Evanoff HL,Kunkel SL,Lukacs NW

更新日期：1996-01-01 00:00:00

abstract：:Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...

journal_title：Mediators of inflammation

authors： Passos BN,Lima MC,Sierra APR,Oliveira RA,Maciel JFS,Manoel R,Rogante JI,Pesquero JB,Cury-Boaventura MF

更新日期：2019-10-07 00:00:00

abstract：:Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...

journal_title：Mediators of inflammation

authors： Wang ZY,Zhang JA,Wu XJ,Liang YF,Lu YB,Gao YC,Dai YC,Yu SY,Jia Y,Fu XX,Rao X,Xu JF,Zhong J

更新日期：2016-01-01 00:00:00

abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

journal_title：Mediators of inflammation

authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

更新日期：2010-01-01 00:00:00

abstract：Background:Inflammation plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We evaluated the lncRNA and mRNA expression profile of peripheral blood mononuclear cells (PBMCs) from healthy nonsmokers, smokers without airflow limitation, and COPD patients. Methods:lncRNA and mRNA pro...

journal_title：Mediators of inflammation

authors： Qu X,Dang X,Wang W,Li Y,Xu D,Shang D,Chang Y

更新日期：2018-03-13 00:00:00

abstract：:The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the presence of adipose tissue. Furthermore, we hypothesized that this au...

journal_title：Mediators of inflammation

authors： Pearson W,Garland AEN,Nixon A,Cant JP,Hurtig MB

更新日期：2020-11-12 00:00:00

abstract：:Microparticles (MPs) are induced during apoptosis, cell activation, and even "spontaneous" release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs de...

journal_title：Mediators of inflammation

authors： Burbano C,Rojas M,Vásquez G,Castaño D

更新日期：2015-01-01 00:00:00

abstract：:Dyslipidemia is associated with increased arterial stiffness (AS) which may lead to hypertension. Among the methods to assess AS are carotid-femoral and brachial-ankle pulse wave velocity. Dyslipidemia is also known to trigger inflammation. C-reactive protein (CRP) is one of the commonest inflammatory markers measured...

journal_title：Mediators of inflammation

authors： Aminuddin A,Lazim MRMLM,Hamid AA,Hui CK,Mohd Yunus MH,Kumar J,Ugusman A

更新日期：2020-08-18 00:00:00

abstract：:Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individ...

journal_title：Mediators of inflammation

authors： Posadas-Sánchez R,Pérez-Hernández N,Angeles-Martínez J,López-Bautista F,Villarreal-Molina T,Rodríguez-Pérez JM,Fragoso JM,Posadas-Romero C,Vargas-Alarcón G

更新日期：2017-01-01 00:00:00

abstract：:Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...

journal_title：Mediators of inflammation

authors： Vaswani K,Chan HW,Peiris HN,Nitert MD,Bradley RJ,Armitage JA,Rice GE,Mitchell MD

更新日期：2015-01-01 00:00:00

abstract：:We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...

journal_title：Mediators of inflammation

authors： Liu Y,Wu Z,Zhang X,Ni J,Yu W,Zhou Y,Nakanishi H

更新日期：2013-01-01 00:00:00

abstract：Background:Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) ...

journal_title：Mediators of inflammation

authors： Zhu X,Ji MH,Li SM,Li B,Mei L,Yang JJ

更新日期：2019-05-09 00:00:00

abstract：:Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psor...

journal_title：Mediators of inflammation

authors： Rodríguez-Cerdeira C,Cordeiro-Rodríguez M,Carnero-Gregorio M,López-Barcenas A,Martínez-Herrera E,Fabbrocini G,Sinani A,Arenas-Guzmán R,González-Cespón JL

更新日期：2019-05-28 00:00:00

abstract：:Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients w...

journal_title：Mediators of inflammation

authors： Lenglet S,Quercioli A,Fabre M,Galan K,Pelli G,Nencioni A,Bauer I,Pende A,Python M,Bertolotto M,Spinella G,Pane B,Palombo D,Dallegri F,Mach F,Vuilleumier N,Montecucco F

更新日期：2014-01-01 00:00:00

abstract：:Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a c...

journal_title：Mediators of inflammation

authors： Puccetti M,Paolicelli G,Oikonomou V,De Luca A,Renga G,Borghi M,Pariano M,Stincardini C,Scaringi L,Giovagnoli S,Ricci M,Romani L,Zelante T

更新日期：2018-02-18 00:00:00

abstract：Background:Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced...

journal_title：Mediators of inflammation

authors： Chang B,Li B,Sun Y,Teng G,Huang A,Li J,Zou Z

更新日期：2017-01-01 00:00:00

abstract：:Trypanosoma cruzi infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high (HIII) or low (LIII) antibody (Ab) responses to complex antigens. Resistance was associated with gender (females) and strain-the high responder lines AIRmax and HIII were re...

journal_title：Mediators of inflammation

authors： Vorraro F,Cabrera WH,Ribeiro OG,Jensen JR,De Franco M,Ibañez OM,Starobinas N

更新日期：2014-01-01 00:00:00