Abstract:
:Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serves as a potential immunotherapeutic target for cancer treatment. However, it is not fully understood whether anticytokine therapy could reverse chemosensitivity and enhance the suppressive effect of chemotherapy on tumor growth. In this study, we aimed to investigate the effect of IL-6 inhibition therapy on the antitumor effect of carboplatin. Enhanced expression of IL-6 and activation of STAT3 were observed in human colorectal carcinoma samples compared to normal colorectal tissue, with higher levels of IL-6/STAT3 in low grade carcinomas. Treatment of carboplatin (CBP) dose-dependently increased IL-6 production and STAT3 activation in human colorectal LoVo cells. Blockade of IL-6 with neutralizing antibody enhanced chemosensitivity of LoVo cells to carboplatin as evidenced by increased cell apoptosis. IL-6 blockade abolished carboplatin-induced STAT3 activation. IL-6 blockade and carboplatin synergistically reduced cyclin D1 expression and enhanced caspase-3 activity in LoVo cells. Our results suggest that inhibition of IL-6 may enhance chemosensitivity of colon cancers with overactive STAT3 to platinum agents.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Wang ZY,Zhang JA,Wu XJ,Liang YF,Lu YB,Gao YC,Dai YC,Yu SY,Jia Y,Fu XX,Rao X,Xu JF,Zhong Jdoi
10.1155/2016/8026494subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8026494eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
杂志文章abstract::The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990621
更新日期:1999-01-01 00:00:00
abstract:Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5270657
更新日期:2018-06-21 00:00:00
abstract:BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124155
更新日期:2001-06-01 00:00:00
abstract::Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3172647
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND/AIM:Coronary artery ectasia (CAE) was thought of as a variant of atherosclerosis. C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovasc...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/89649
更新日期:2007-01-01 00:00:00
abstract:AIM:To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. METHODS:Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/214581
更新日期:2012-01-01 00:00:00
abstract::Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 c...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/205156
更新日期:2015-01-01 00:00:00
abstract::The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill patients. Despite decades of research, few therapeutic strategies for clinical ARDS have emerged. Here we carefully evaluated the effect o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/540794
更新日期:2012-01-01 00:00:00
abstract::Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/987927
更新日期:2014-01-01 00:00:00
abstract:Objective:Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods:Rat RI/RI models were constructed by surgical ope...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8869511
更新日期:2020-11-24 00:00:00
abstract::We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000330
更新日期:1995-01-01 00:00:00
abstract::The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/279365
更新日期:2013-01-01 00:00:00
abstract::We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/407562
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. METHODS:The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group. Myocardial infarct size, markers of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/1232103
更新日期:2016-01-01 00:00:00
abstract::Early onset sepsis due to group B streptococcus leads to neonatal morbidity, increased mortality, and long-term neurological deficencies. Interaction between septicemic GBS and confluent monolayers of human coronary artery endothelial cells (HCAECs) was analyzed by genome wide expression profiling. In total, 124 genes...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/971502
更新日期:2011-01-01 00:00:00
abstract::Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune disease...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/834831
更新日期:2014-01-01 00:00:00
abstract:Objective:Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7903140
更新日期:2020-08-04 00:00:00
abstract::Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study wa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6848430
更新日期:2017-01-01 00:00:00
abstract::Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/183041
更新日期:2013-01-01 00:00:00
abstract::Bortezomib is a proteasome inhibitor used for hematologic cancer treatment. Since it can suppress NF-κB activation, which is critical for the inflammatory process, bortezomib has been found to possess anti-inflammatory activity. In this study, we evaluated the effect of bortezomib on experimental autoimmune uveitis (E...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/847373
更新日期:2015-01-01 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/785265
更新日期:2011-01-01 00:00:00
abstract::This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7201549
更新日期:2016-01-01 00:00:00
abstract::Observation of the microcirculation of the hamster cheek pouch by intravital microscopy revealed five steps of neutrophil migration from the venules after topical application of leukotriene B(4) to the microvasculature: rolling along the venular wall (Step 1), adhesion to it (Step 2), disappearance from the vascular l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000238
更新日期:1995-01-01 00:00:00
abstract::Behçet's disease (BD) is a multisystemic disorder of unknown etiology characterized by the "triple symptom complex" consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis. Recurrent mucocutaneous lesions are generally considered the hallmark of the disease, being the most commo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/451675
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/740357
更新日期:2015-01-01 00:00:00
abstract::Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investiga...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4267158
更新日期:2018-03-18 00:00:00
abstract::We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-alpha,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000731
更新日期:1995-01-01 00:00:00
abstract::Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/930894
更新日期:2014-01-01 00:00:00
abstract::Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4097574
更新日期:2016-01-01 00:00:00
abstract::Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Different species of the genus Lactobacillus can evoke differe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/237921
更新日期:2013-01-01 00:00:00