Abstract:
:Bortezomib is a proteasome inhibitor used for hematologic cancer treatment. Since it can suppress NF-κB activation, which is critical for the inflammatory process, bortezomib has been found to possess anti-inflammatory activity. In this study, we evaluated the effect of bortezomib on experimental autoimmune uveitis (EAU) in mice and investigated the potential mechanisms related to NF-κB inactivation. High-dose bortezomib (0.75 mg/kg), low-dose bortezomib (0.15 mg/kg), or phosphate buffered saline was given after EAU induction. We found that the EAU is ameliorated by high-dose bortezomib treatment when compared with low-dose bortezomib or PBS treatment. The DNA-binding activity of NF-κB was suppressed and expression of several key inflammatory mediators including TNF-α, IL-1α, IL-1β, IL-12, IL-17, and MCP-1 was lowered in the high-dose bortezomib-treated group. These results suggest that proteasome inhibition is a promising treatment strategy for autoimmune uveitis.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Hsu SM,Yang CH,Shen FH,Chen SH,Lin CJ,Shieh CCdoi
10.1155/2015/847373subject
Has Abstractpub_date
2015-01-01 00:00:00pages
847373eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
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journal_title:Mediators of inflammation
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更新日期:2014-01-01 00:00:00
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