Immunotherapy of Crohn's disease.

abstract：:This study investigated the protective effects of intravitreal Resolvin D1 (RvD1) against LPS-induced rat endotoxic uveitis (EIU). RvD1 was administered into the right eye at a single injection of 5 μL volume containing 10-100-1000 ng/kg RvD1 1 h post-LPS injection (200 μg, Salmonella minnesota) into thefootpad of Spr...

journal_title：Mediators of inflammation

authors： Rossi S,Di Filippo C,Gesualdo C,Potenza N,Russo A,Trotta MC,Zippo MV,Maisto R,Ferraraccio F,Simonelli F,D'Amico M

更新日期：2015-01-01 00:00:00

abstract：:Dyslipidemia is associated with increased arterial stiffness (AS) which may lead to hypertension. Among the methods to assess AS are carotid-femoral and brachial-ankle pulse wave velocity. Dyslipidemia is also known to trigger inflammation. C-reactive protein (CRP) is one of the commonest inflammatory markers measured...

journal_title：Mediators of inflammation

authors： Aminuddin A,Lazim MRMLM,Hamid AA,Hui CK,Mohd Yunus MH,Kumar J,Ugusman A

更新日期：2020-08-18 00:00:00

abstract：:There is much evidence that degradation of the extracellular matrix is essential for the development of cholesteatomas and that this is induced by activation of matrix metalloproteinases (MMPs). Vitamin D3 (VD3) has several well-recognised biological activities, including suppression of MMP production. The present stu...

journal_title：Mediators of inflammation

authors： Kobayashi H,Asano K,Kanai K,Suzaki H

更新日期：2005-08-31 00:00:00

abstract：:Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...

journal_title：Mediators of inflammation

authors： De Cunto G,Lamberti A,de Santi MM,Miracco C,Fimiani M,Lungarella G,Cavarra E

更新日期：2017-01-01 00:00:00

abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

journal_title：Mediators of inflammation

authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

更新日期：2010-01-01 00:00:00

abstract：:We investigated whether TNB alters colonic tissue levels of PAF at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene. Strain gauge transducers were sewn...

journal_title：Mediators of inflammation

authors： Longo WE,Standeven J,Chandel B,Deshpande Y,Vernava AM,Kaminski D

更新日期：1995-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoar...

journal_title：Mediators of inflammation

authors： Gelderman MP,Stuart R,Vigerust D,Fuhrmann S,Lefkowitz DL,Allen RC,Lefkowitz SS,Graham S

更新日期：1998-01-01 00:00:00

abstract：:In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement ...

journal_title：Mediators of inflammation

authors： Rouabhia M,Semlali A,Chandra J,Mukherjee P,Chmielewski W,Ghannoum MA

更新日期：2012-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca(2+) channel (L-VDCC) current in cardiac myocytes, an observation that seems parado...

journal_title：Mediators of inflammation

authors： Reyes-García J,Flores-Soto E,Solís-Chagoyán H,Sommer B,Díaz-Hernández V,García-Hernández LM,Montaño LM

更新日期：2016-01-01 00:00:00

abstract：:Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...

journal_title：Mediators of inflammation

authors： Cheng YL,Lin YS,Chen CL,Wan SW,Ou YD,Yu CY,Tsai TT,Tseng PC,Lin CF

更新日期：2015-01-01 00:00:00

abstract：:Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...

journal_title：Mediators of inflammation

authors： Vodo S,Bechi N,Petroni A,Muscoli C,Aloisi AM

更新日期：2013-01-01 00:00:00

abstract：:OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...

journal_title：Mediators of inflammation

authors： Roayaie S,Sheiner PA,Emre S,Guy S,Schwartz ME,Boros P,Miller CM

更新日期：2000-01-01 00:00:00

abstract：:The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...

journal_title：Mediators of inflammation

authors： Safrankova B,Gajdova S,Kubala L

更新日期：2010-01-01 00:00:00

abstract：:Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a compl...

journal_title：Mediators of inflammation

authors： Dong Z,Xiong L,Zhang W,Gibson PG,Wang T,Lu Y,Wang G,Li H,Wang F

更新日期：2016-01-01 00:00:00

abstract：:Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...

journal_title：Mediators of inflammation

authors： Petricevich VL

更新日期：2010-01-01 00:00:00

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...

journal_title：Mediators of inflammation

authors： Daïen CI,Morel J

更新日期：2014-01-01 00:00:00

abstract：:Colitis is a major form of inflammatory bowel disease which involved mucosal immune dysfunction. Aloperine is an alkaloid isolated from the shrub Sophora alopecuroides L. and has been recognized as an effective treatment for inflammatory and allergic diseases. The present study aimed to examine the molecular mechanism...

journal_title：Mediators of inflammation

authors： Fu X,Sun F,Wang F,Zhang J,Zheng B,Zhong J,Yue T,Zheng X,Xu JF,Wang CY

更新日期：2017-01-01 00:00:00

abstract：:Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/recept...

journal_title：Mediators of inflammation

authors： Knerlich-Lukoschus F,Held-Feindt J

更新日期：2015-01-01 00:00:00

abstract：:Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...

journal_title：Mediators of inflammation

authors： Lehmann C,Islam S,Jarosch S,Zhou J,Hoskin D,Greenshields A,Al-Banna N,Sharawy N,Sczcesniak A,Kelly M,Wafa K,Cheliak W,Holbein B

更新日期：2015-01-01 00:00:00

abstract：:Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression ...

journal_title：Mediators of inflammation

authors： Plawecki M,Morena M,Kuster N,Chenine L,Leray-Moragues H,Jover B,Fesler P,Lotierzo M,Dupuy AM,Klouche K,Cristol JP

更新日期：2018-10-08 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological inflammation, and coexistence with primary sclerosing cholangitis (PSC). Several molecular pathway...

journal_title：Mediators of inflammation

authors： Luo C,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...

journal_title：Mediators of inflammation

authors： Wang J,Yan S,Lu H,Wang S,Xu D

更新日期：2019-10-24 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：:The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macro...

journal_title：Mediators of inflammation

authors： Boudjeltia KZ,Delporte C,Van Antwerpen P,Franck T,Serteyn D,Moguilevsky N,Raes M,Vanhamme L,Vanhaeverbeek M,Van Meerhaeghe A,Roumeguère T

更新日期：2013-01-01 00:00:00

abstract：:Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...

journal_title：Mediators of inflammation

authors： Sartori C,Lazzeroni P,Merli S,Patianna VD,Viaroli F,Cirillo F,Amarri S,Street ME

更新日期：2016-01-01 00:00:00

abstract：:We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...

journal_title：Mediators of inflammation

authors： Liu Y,Wu Z,Zhang X,Ni J,Yu W,Zhou Y,Nakanishi H

更新日期：2013-01-01 00:00:00

abstract：Objective:Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity ...

journal_title：Mediators of inflammation

authors： Tang HN,Xiao F,Chen YR,Zhuang SQ,Guo Y,Wu HX,Zhou HD

更新日期：2020-08-04 00:00:00

abstract：:Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and neurodegeneration. During angiogenesis and vascular remodeling, behaviors of stem/progenitor cells, endothelial cells (ECs), and vascular smooth mus...

journal_title：Mediators of inflammation

authors： Chen Q,Jin M,Yang F,Zhu J,Xiao Q,Zhang L

更新日期：2013-01-01 00:00:00

abstract：:Infiltration and local proliferation are known factors that contribute to tubulointerstitial macrophage accumulation. This study explored the time course of these two contributors' roles as tubulointerstitial inflammation and fibrosis progressing, and evaluated the mechanisms of the protective effect of atorvastatin. ...

journal_title：Mediators of inflammation

authors： Tian S,Ding G,Jia R,Chu G

更新日期：2006-01-01 00:00:00