Abstract:
:Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological inflammation, and coexistence with primary sclerosing cholangitis (PSC). Several molecular pathways that contribute to sporadic CRC are also involved in the pathogenesis of colitis-associated CRC. It is well established that long-standing chronic inflammation is a key predisposing factor of CRC in IBD. Proinflammatory pathways, including nuclear factor kappa B (NF-κB), IL-6/STAT3, cyclooxygenase-2 (COX-2)/PGE2, and IL-23/Th17, promote tumorigenesis by inducing the production of inflammatory mediators, upregulating the expression of antiapoptotic genes, and stimulating cell proliferation as well as angiogenesis. Better understanding of the underlying mechanisms may provide some promising targets for prevention and therapy. This review aims to elucidate the role of these signaling pathways in the pathogenesis of colitis-associated CRC using evidence-based approaches.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Luo C,Zhang Hdoi
10.1155/2017/5126048subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5126048eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章,评审abstract::Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and pu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2309175
更新日期:2019-01-16 00:00:00
abstract::High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA IgG antibodies from patients with ty...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/196297
更新日期:2015-01-01 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/9524075
更新日期:2018-08-27 00:00:00
abstract:UNLABELLED:The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children. METHODS:A cross-sectional study was performed in 180 steroid dependent atopic children...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/49240
更新日期:2007-01-01 00:00:00
abstract::Interleukin-10 (IL-10) is a cytokine derived from CD4+ T-helper type 2 (T(H2)) cells identified as a suppressor of cytokines from T-helper type 1(T(H1)) cells. Interleukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates T(H1) cell differentiation, while suppressing the expan...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1080/09629350120054518
更新日期:2001-04-01 00:00:00
abstract::Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/850940
更新日期:2009-01-01 00:00:00
abstract:Background:Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4321912
更新日期:2020-06-06 00:00:00
abstract::Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased dono...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/501430
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/6947482.]. ...
journal_title:Mediators of inflammation
pub_type: 已发布勘误
doi:10.1155/2020/2637019
更新日期:2020-11-21 00:00:00
abstract::Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/9086758
更新日期:2019-07-10 00:00:00
abstract::Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8102170
更新日期:2017-01-01 00:00:00
abstract::Fluid of artificial blisters from erythromelalgic skin areas in primary thrombocythaemia contained a high amount of prostaglandin-E-like activity. Dazoxiben did not alleviate the erythromelalgia in patients with primary thrombocythaemia despite complete inhibition of platelet malondialdehyde and thromboxane B(2) synth...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000547
更新日期:1993-01-01 00:00:00
abstract:Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/5650627
更新日期:2017-01-01 00:00:00
abstract::Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/7501985
更新日期:2018-11-18 00:00:00
abstract::Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8026494
更新日期:2016-01-01 00:00:00
abstract::Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3270513
更新日期:2020-01-20 00:00:00
abstract::Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/754965
更新日期:2014-01-01 00:00:00
abstract::Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calciu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/375427
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/31919
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7089137
更新日期:2016-01-01 00:00:00
abstract::B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Although B-1a cells are ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/9289417
更新日期:2018-12-23 00:00:00
abstract::Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammator...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2021/8874339
更新日期:2021-01-14 00:00:00
abstract::Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/574817
更新日期:2012-01-01 00:00:00
abstract::Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4786170
更新日期:2017-01-01 00:00:00
abstract::Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induced skeletal muscle i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/865159
更新日期:2013-01-01 00:00:00
abstract::Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4097574
更新日期:2016-01-01 00:00:00
abstract:Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/1936960
更新日期:2020-05-27 00:00:00
abstract::Observation of the microcirculation of the hamster cheek pouch by intravital microscopy revealed five steps of neutrophil migration from the venules after topical application of leukotriene B(4) to the microvasculature: rolling along the venular wall (Step 1), adhesion to it (Step 2), disappearance from the vascular l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000238
更新日期:1995-01-01 00:00:00
abstract::Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/134605
更新日期:2012-01-01 00:00:00
abstract::To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/612038
更新日期:2013-01-01 00:00:00