Abstract:
:Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoarticular arthritis was induced in female Lewis rats by injection of streptococcal cell wall extracts (PG-APS). After swelling and erythema subsided, joints were re-injected with one of the following: porcine MPO or partially inactivated MPO (iMPO). Injection with either MPO or iMPO induced a 'flare' of experimental RA. Blocking the Mphi-mannose receptor by mannans, ablated exacerbation of disease. These results indicate that MPO or iMPO can play a pivotal role in the perpetuation but not initiation of this RA model.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Gelderman MP,Stuart R,Vigerust D,Fuhrmann S,Lefkowitz DL,Allen RC,Lefkowitz SS,Graham Sdoi
10.1080/09629359890758subject
Has Abstractpub_date
1998-01-01 00:00:00pages
381-9issue
6eissn
0962-9351issn
1466-1861journal_volume
7pub_type
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