Abstract:
BACKGROUND:Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS:In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS:Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2), and the presence of antibodies against PAF were investigated in 17 SLE patients without active nephritis and in 17 healthy controls. RESULTS:Blood PAF levels were not different (p=0.45) between SLE patients (6.7+/-2.8 pg/ml) and healthy subjects (9.6+/-3.1 pg/ml). Plasma acetylhydrolase activity (the PAF-degrading enzyme) was significantly (p=0.03) elevated in SLE patients (57.8+/-6.4 nmol/min/ml) as compared with controls (37.9+/-2.6 nmol/min/ml). Plasma soluble phospholipase A(2) (the key enzyme for PAF formation) was not different (p=0.6) between SLE patients (59.1+/-5.1 U/ml) and controls (54.7+/-2.4 U/ml). Antibodies against PAF were detected only in 3/17 SLE patients. Flow cytometry analysis did not highlight PAF receptors on circulating leukocytes of SLE patients. CONCLUSION:This clinical study highlights no evidence for a putative important role of PAF in SLE patients without active nephritis.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Denizot Y,Liozon E,Guglielmi L,Ly K,Soria P,Loustaud V,Vidal E,Jauberteau MOdoi
10.1080/0962935031000097718subject
Has Abstractpub_date
2003-04-01 00:00:00pages
101-5issue
2eissn
0962-9351issn
1466-1861pii
MA13BDHG2TKXWE8Djournal_volume
12pub_type
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journal_title:Mediators of inflammation
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abstract::[This retracts the article DOI: 10.1155/2018/4514329.]. ...
journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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