Abstract:
BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. METHODS:We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed. Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy. Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters. RESULTS:Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) (p = 0.009). Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs = 0.529, p = 0.043) and α-smooth muscle actin (α-SMA) (rs = 0.554, p = 0.032). FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (rs = 0.536, p = 0.040), α-SMA (rs = 0.561, p = 0.029), fibrosis levels (rs = 0.779, p = 0.001), and the thickness of the airway reticular basement membrane (RBM) (rs = 0.660, p = 0.007). CONCLUSIONS:FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Liu Y,Liu T,Wu J,Li T,Jiao X,Zhang H,Zhao J,Wang J,Liu L,Cao L,Li S,Xu J,Xu J,Ma X,Yang L,Dong Ldoi
10.1155/2017/7918472subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7918472eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章abstract::The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...
journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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更新日期:2010-01-01 00:00:00
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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pub_type: 杂志文章,meta分析,评审
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journal_title:Mediators of inflammation
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pub_type: 杂志文章
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/9191743
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/501430
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/3890601
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350210000015683
更新日期:2002-10-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/720987
更新日期:2014-01-01 00:00:00