Tubulointerstitial macrophage accumulation is regulated by sequentially expressed osteopontin and macrophage colony-stimulating factor: implication for the role of atorvastatin.

abstract：BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...

journal_title：Mediators of inflammation

authors： McKay S,Bromhaar MM,de Jongste JC,Hoogsteden HC,Saxena PR,Sharma HS

更新日期：2001-06-01 00:00:00

abstract：:Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...

journal_title：Mediators of inflammation

authors： Yan X,Xie B,Wu G,Hu J,Wang D,Cai X,Li J

更新日期：2019-01-08 00:00:00

abstract：:Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...

journal_title：Mediators of inflammation

authors： Wang J,Yan S,Lu H,Wang S,Xu D

更新日期：2019-10-24 00:00:00

abstract：:Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintena...

journal_title：Mediators of inflammation

authors： Sykes L,MacIntyre DA,Yap XJ,Teoh TG,Bennett PR

更新日期：2012-01-01 00:00:00

abstract：:Long-term exposure to crystalline silica leads to silicosis, which is characterized by persistent lung inflammation and lung fibrosis. Multiple immune cells have been demonstrated to participate in crystalline silica-induced immune responses. Our previous study indicated that B10 could control lung inflammation throug...

journal_title：Mediators of inflammation

authors： Lu Y,Liu F,Li C,Chen Y,Weng D,Chen J

更新日期：2017-01-01 00:00:00

abstract：:The effects of intravenous injection of Porphyromonas gingivalis (Pg) on rabbit inflammatory immune response and atherosclerosis were evaluated by establishing a microamount Pg bacteremia model combined with high-fat diet. Twenty-four New Zealand rabbits were randomly divided into Groups A-D (n = 6). After 14 weeks, l...

journal_title：Mediators of inflammation

authors： Lin G,Chen S,Lei L,You X,Huang M,Luo L,Li Y,Zhao X,Yan F

更新日期：2015-01-01 00:00:00

abstract：:Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...

journal_title：Mediators of inflammation

authors： Sartori C,Lazzeroni P,Merli S,Patianna VD,Viaroli F,Cirillo F,Amarri S,Street ME

更新日期：2016-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...

journal_title：Mediators of inflammation

authors： Sedda S,Marafini I,Figliuzzi MM,Pallone F,Monteleone G

更新日期：2014-01-01 00:00:00

abstract：:Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and ...

journal_title：Mediators of inflammation

authors： Wang J,Zhao P,Guo H,Sun X,Jiang Z,Xu L,Feng J,Niu J,Jiang Y

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised ...

journal_title：Mediators of inflammation

authors： Sallam N,Khazaei M,Laher I

更新日期：2010-01-01 00:00:00

abstract：Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...

journal_title：Mediators of inflammation

authors： Han W,Wang H,Su L,Long Y,Cui N,Liu D

更新日期：2018-06-28 00:00:00

abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

journal_title：Mediators of inflammation

authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

更新日期：1993-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are multifactorial disorders resulting from environmental and genetic factors. Polymorphisms in MDR1 and GSTs genes might explain individual differences in susceptibility to IBD. We carried out a case-control study to examine the association of MDR1 (C1236T and C3435T), GSTT1, and GST...

journal_title：Mediators of inflammation

authors： Senhaji N,Kassogue Y,Fahimi M,Serbati N,Badre W,Nadifi S

更新日期：2015-01-01 00:00:00

abstract：:Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA(4) on the expression of cyclooxygenase-2 in lipopolysaccharide-s...

journal_title：Mediators of inflammation

authors： Zheng S,Wang Q,He Q,Song X,Ye D,Gao F,Jin S,Lian Q

更新日期：2011-01-01 00:00:00

abstract：:Cardiovascular disease linked to atherosclerosis is the leading cause of death worldwide. Atherosclerosis is mainly linked to dysfunction in vascular endothelial cells and subendothelial accumulation of oxidized forms of LDL. In the present study, we investigated the role of myeloperoxidase oxidized LDL (Mox-LDL) in e...

journal_title：Mediators of inflammation

authors： Daher J,Martin M,Rousseau A,Nuyens V,Fayyad-Kazan H,Van Antwerpen P,Courbebaisse G,Martiat P,Badran B,Dequiedt F,Zouaoui Boudjeltia K,Vanhamme L

更新日期：2014-01-01 00:00:00

abstract：:Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in of...

journal_title：Mediators of inflammation

authors： Almeida Morais C,Oyama LM,de Oliveira JL,Carvalho Garcia M,de Rosso VV,Sousa Mendes Amigo L,do Nascimento CM,Pisani LP

更新日期：2014-01-01 00:00:00

abstract：:Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inf...

journal_title：Mediators of inflammation

authors： Zhang S,Kan QC,Xu Y,Zhang GX,Zhu L

更新日期：2013-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune connective tissue disorder of unknown etiology. This disease is characterized by a large variety of clinical patterns, which include the fibrosis of skin and visceral organs causing a variety of clinical manifestations. Genetic and environmental factors participate in the etio...

journal_title：Mediators of inflammation

authors： Grygiel-Górniak B,Puszczewicz M

更新日期：2014-01-01 00:00:00

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill patients. Despite decades of research, few therapeutic strategies for clinical ARDS have emerged. Here we carefully evaluated the effect o...

journal_title：Mediators of inflammation

authors： Guo Z,Li Q,Han Y,Liang Y,Xu Z,Ren T

更新日期：2012-01-01 00:00:00

abstract：:CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...

journal_title：Mediators of inflammation

authors： Rotondi M,Coperchini F,Awwad O,Pignatti P,Di Buduo CA,Abbonante V,Magri F,Balduini A,Chiovato L

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...

journal_title：Mediators of inflammation

authors： Jung C,Gerdes N,Fritzenwanger M,Figulla HR

更新日期：2010-01-01 00:00:00

abstract：:In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. The corticotropin-releasing hormone and glucocorticoids are cr...

journal_title：Mediators of inflammation

authors： Aguirre A,Maturana CJ,Harcha PA,Sáez JC

更新日期：2013-01-01 00:00:00

abstract：:H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...

journal_title：Mediators of inflammation

authors： Li R,Jiang XX,Zhang LF,Liu XM,Hu TZ,Xia XJ,Li M,Xu CX

更新日期：2017-01-01 00:00:00

abstract：:Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body's response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, pr...

journal_title：Mediators of inflammation

authors： Albulescu R,Codrici E,Popescu ID,Mihai S,Necula LG,Petrescu D,Teodoru M,Tanase CP

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

journal_title：Mediators of inflammation

authors： Bajnok A,Ivanova M,Rigó J Jr,Toldi G

更新日期：2017-01-01 00:00:00

abstract：Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...

journal_title：Mediators of inflammation

authors： Colica C,Avolio E,Bollero P,Costa de Miranda R,Ferraro S,Sinibaldi Salimei P,De Lorenzo A,Di Renzo L

更新日期：2017-01-01 00:00:00

abstract：:Procalcitonin (PCT) is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested ...

journal_title：Mediators of inflammation

authors： Rami D,La Bianca M,Agostinis C,Zauli G,Radillo O,Bulla R

更新日期：2014-01-01 00:00:00

abstract：:There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning ...

journal_title：Mediators of inflammation

authors： León OS,Menéndez S,Merino N,Castillo R,Sam S,Pérez L,Cruz E,Bocci V

更新日期：1998-01-01 00:00:00

abstract：:Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during ...

journal_title：Mediators of inflammation

authors： Gandini M,Petitinga-Paiva F,Marinho CF,Correa G,De Oliveira-Pinto LM,de Souza LJ,Cunha RV,Kubelka CF,de Azeredo EL

更新日期：2017-01-01 00:00:00