Ozone oxidative preconditioning: a protection against cellular damage by free radicals.

abstract：:Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 pa...

journal_title：Mediators of inflammation

authors： Denizot Y,Fixe P,Cornu E,Nathan N

更新日期：1996-01-01 00:00:00

abstract：:Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...

journal_title：Mediators of inflammation

authors： Galvão A,Tramontano A,Rebordão MR,Amaral A,Bravo PP,Szóstek A,Skarzynski D,Mollo A,Ferreira-Dias G

更新日期：2014-01-01 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00

abstract：:Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...

journal_title：Mediators of inflammation

authors： Costantini E,D'Angelo C,Reale M

更新日期：2018-03-08 00:00:00

abstract：OBJECTIVE:Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. METHODS:Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-a...

journal_title：Mediators of inflammation

authors： Kartal Durmazlar SP,Akgul A,Eskioglu F

更新日期：2008-01-01 00:00:00

abstract：:The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass in...

journal_title：Mediators of inflammation

authors： Ma J,Guo W,Li Z,Wang B,Li S,Wang P

更新日期：2017-01-01 00:00:00

abstract：:Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple cytokines. Although dysregulation of interleukin- (IL-) 22 is invol...

journal_title：Mediators of inflammation

authors： Liang M,Wang J,Chu H,Zhu X,He H,Liu Q,Qiu J,Zhou X,Guan M,Xue Y,Chen X,Zou H

更新日期：2013-01-01 00:00:00

abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

journal_title：Mediators of inflammation

authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (co...

journal_title：Mediators of inflammation

authors： Ferreira L,Teixeira-de-Lemos E,Pinto F,Parada B,Mega C,Vala H,Pinto R,Garrido P,Sereno J,Fernandes R,Santos P,Velada I,Melo A,Nunes S,Teixeira F,Reis F

更新日期：2010-01-01 00:00:00

abstract：:Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and infla...

journal_title：Mediators of inflammation

authors： Li Y,Wang Y,Liu Y,Wang Y,Zuo X,Li Y,Lu X

更新日期：2014-01-01 00:00:00

abstract：:Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...

journal_title：Mediators of inflammation

authors： Daïen CI,Morel J

更新日期：2014-01-01 00:00:00

abstract：AIM:To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. METHODS:Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided i...

journal_title：Mediators of inflammation

authors： Doğan Y,Erkan T,Önal Z,Usta M,Doğusoy G,Çokuğraş FÇ,Kutlu T

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), interleukin 18 (IL-18), an...

journal_title：Mediators of inflammation

authors： El-Mesallamy HO,Hamdy NM,El-Etriby AK,Wasfey EF

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:TRAIL is a potential biomarker of cardiovascular (CV) disease. Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with metabolic syndrome (MeS) and accelerated atherosclerosis. We assessed whether disease activity, systemic inflammation, and MeS features were associated with circulating ...

journal_title：Mediators of inflammation

authors： Genre F,López-Mejías R,Rueda-Gotor J,Miranda-Filloy JA,Ubilla B,Carnero-López B,Palmou-Fontana N,Gómez-Acebo I,Blanco R,Pina T,Ochoa R,González-Juanatey C,Llorca J,González-Gay MA

更新日期：2014-01-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor used for hematologic cancer treatment. Since it can suppress NF-κB activation, which is critical for the inflammatory process, bortezomib has been found to possess anti-inflammatory activity. In this study, we evaluated the effect of bortezomib on experimental autoimmune uveitis (E...

journal_title：Mediators of inflammation

authors： Hsu SM,Yang CH,Shen FH,Chen SH,Lin CJ,Shieh CC

更新日期：2015-01-01 00:00:00

abstract：:Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...

journal_title：Mediators of inflammation

authors： Alipoor SD,Mortaz E,Garssen J,Movassaghi M,Mirsaeidi M,Adcock IM

更新日期：2016-01-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several experimental disease models. We used the non...

journal_title：Mediators of inflammation

authors： Cornélio Favarin D,Martins Teixeira M,Lemos de Andrade E,de Freitas Alves C,Lazo Chica JE,Artério Sorgi C,Faccioli LH,Paula Rogerio A

更新日期：2013-01-01 00:00:00

abstract：:Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calciu...

journal_title：Mediators of inflammation

authors： Khaleel A,Wu MS,Wong HS,Hsu YW,Chou YH,Chen HY

更新日期：2015-01-01 00:00:00

abstract：AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...

journal_title：Mediators of inflammation

authors： Basyigit I,Yildiz F,Ozkara SK,Boyaci H,Ilgazli A

更新日期：2004-08-01 00:00:00

abstract：:Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...

journal_title：Mediators of inflammation

authors： Wang J,Li Y,Zhao P,Tian Y,Liu X,He H,Jia R,Oliver BG,Li J

更新日期：2020-05-08 00:00:00

abstract：:L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS). NO decomposes into other nitrogen oxides such as nitrite (NO(2) (-)) and nitrate (NO(2) (-)), and in the presence of superoxide anion to the potent oxidizing agent peroxynitrit...

journal_title：Mediators of inflammation

authors： Jorens PG,Matthys KE,Bult H

更新日期：1995-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefo...

journal_title：Mediators of inflammation

authors： Arcidiacono MV,Martinez-Alonso M,Belart M,Vilar A,Martín M,Craver L,Betriu À,Mauricio D,Valdivielso JM,Fernández E,Borràs M

更新日期：2017-01-01 00:00:00

abstract：:Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inf...

journal_title：Mediators of inflammation

authors： Zhang S,Kan QC,Xu Y,Zhang GX,Zhu L

更新日期：2013-01-01 00:00:00

abstract：:Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacill...

journal_title：Mediators of inflammation

authors： Jiang M,Deng K,Jiang C,Fu M,Guo C,Wang X,Wang X,Meng F,Yang S,Deng K,Chen T,Xin H

更新日期：2016-01-01 00:00:00

abstract：:We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia ...

journal_title：Mediators of inflammation

authors： Góra-Tybor J,Warzocha K,Robak T

更新日期：1995-01-01 00:00:00

abstract：:To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...

journal_title：Mediators of inflammation

authors： Tamaoki J,Chiyotani A,Tagaya E,Isono K,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with ...

journal_title：Mediators of inflammation

authors： Hermouet S,Bigot-Corbel E,Gardie B

更新日期：2015-01-01 00:00:00

abstract：:Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal mon...

journal_title：Mediators of inflammation

authors： Platen C,Dreschers S,Wappler J,Ludwig A,Düsterhöft S,Reiss LK,Orlikowsky TW

更新日期：2019-11-03 00:00:00

abstract：:The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...

journal_title：Mediators of inflammation

authors： Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Z

更新日期：2016-01-01 00:00:00