Opposing roles of leptin and ghrelin in the equine corpus luteum regulation: an in vitro study.

abstract：:The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the presence of adipose tissue. Furthermore, we hypothesized that this au...

journal_title：Mediators of inflammation

authors： Pearson W,Garland AEN,Nixon A,Cant JP,Hurtig MB

更新日期：2020-11-12 00:00:00

abstract：:Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...

journal_title：Mediators of inflammation

authors： Cheng W,Chen G

更新日期：2014-01-01 00:00:00

abstract：:Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...

journal_title：Mediators of inflammation

authors： Cheng YL,Lin YS,Chen CL,Wan SW,Ou YD,Yu CY,Tsai TT,Tseng PC,Lin CF

更新日期：2015-01-01 00:00:00

abstract：:Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors incl...

journal_title：Mediators of inflammation

authors： Wojdasiewicz P,Turczyn P,Dobies-Krzesniak B,Frasunska J,Tarnacka B

更新日期：2019-11-12 00:00:00

abstract：:We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...

journal_title：Mediators of inflammation

authors： Cho CW,Ahn S,Lim TG,Hong HD,Rhee YK,Yang DC,Jang M

更新日期：2017-01-01 00:00:00

abstract：:The carrageenan pleurisy model, which is characterized by cellular influx and oedema, has been used to examine the effects of anti-inflammatory compounds such as naproxen. Interleukin-1alpha and beta (IL-1) are known to be pro-inflammatory mediators, and their roles in this model are unknown. Intrapleural injection of...

journal_title：Mediators of inflammation

authors： Goodman R,Mantegna LR,McAilister CL,Bruin E,Dowling RL,George H,Feeser W,Freimark B,Lischwe M,Pick S,Harris RR,Kerr JS

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...

journal_title：Mediators of inflammation

authors： Gong Y,Lin Y,Zhao N,He X,Lu A,Wei W,Jiang M

更新日期：2016-01-01 00:00:00

abstract：:Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of th...

journal_title：Mediators of inflammation

authors： Marcusso Orsini T,Kawakami NY,Panis C,Fortes Dos Santos Thomazelli AP,Tomiotto-Pellissier F,Cataneo AH,Kian D,Megumi Yamauchi L,Gouveia Júnior FS,de França Lopes LG,Cecchini R,Nazareth Costa I,Jerley Nogueira da Silva J,Conchon

更新日期：2016-01-01 00:00:00

abstract：:Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...

journal_title：Mediators of inflammation

authors： Bayer A,Lammel J,Tohidnezhad M,Lippross S,Behrendt P,Klüter T,Pufe T,Cremer J,Jahr H,Rademacher F,Gläser R,Harder J

更新日期：2017-01-01 00:00:00

abstract：:The causes of retinal hypoxia are many and varied. Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines. Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biologica...

journal_title：Mediators of inflammation

authors： dell'Omo R,Semeraro F,Bamonte G,Cifariello F,Romano MR,Costagliola C

更新日期：2013-01-01 00:00:00

abstract：:The effects of anti-inflammatory plant extracts, such as black tea extract (BTE) and resveratrol (RSV) could modulate cell activation leading to atherosclerosis, however there is little comparative information about how different endothelial cell types are affected by these compounds. In order to compare human endothe...

journal_title：Mediators of inflammation

authors： Lakota K,Mrak-Poljsak K,Rozman B,Sodin-Semrl S

更新日期：2009-01-01 00:00:00

abstract：:A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance...

journal_title：Mediators of inflammation

authors： Lopalco G,Cantarini L,Vitale A,Iannone F,Anelli MG,Andreozzi L,Lapadula G,Galeazzi M,Rigante D

更新日期：2015-01-01 00:00:00

abstract：:The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-deri...

journal_title：Mediators of inflammation

authors： Alvarez Y,Valera I,Municio C,Hugo E,Padrón F,Blanco L,Rodríguez M,Fernández N,Crespo MS

更新日期：2010-01-01 00:00:00

abstract：:Edelweiss (Leontopodium alpinum Cass.) is traditionally employed in folk medicine as an anti-inflammatory remedy. In nature, the plant is sparsely available and protected; therefore production of callus cultures was established. A concentrated ethanolic extract of culture homogenate, with leontopodic acid representing...

journal_title：Mediators of inflammation

authors： Daniela L,Alla P,Maurelli R,Elena D,Giovanna P,Vladimir K,Roberto DT,Chiara de L,Saveria P,Liudmila K

更新日期：2012-01-01 00:00:00

abstract：:Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients w...

journal_title：Mediators of inflammation

authors： Lenglet S,Quercioli A,Fabre M,Galan K,Pelli G,Nencioni A,Bauer I,Pende A,Python M,Bertolotto M,Spinella G,Pane B,Palombo D,Dallegri F,Mach F,Vuilleumier N,Montecucco F

更新日期：2014-01-01 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

journal_title：Mediators of inflammation

authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

更新日期：2016-01-01 00:00:00

abstract：:B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Although B-1a cells are ...

journal_title：Mediators of inflammation

authors： Yamamoto W,Toyoda H,Xu DQ,Hanaki R,Morimoto M,Nakato D,Ito T,Iwamoto S,Bonno M,Tanaka S,Hirayama M

更新日期：2018-12-23 00:00:00

abstract：UNLABELLED:The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children. METHODS:A cross-sectional study was performed in 180 steroid dependent atopic children...

journal_title：Mediators of inflammation

authors： Nuijsink M,Hop WC,Sterk PJ,Duiverman EJ,Hiemstra PS,de Jongste JC,CATO Study Group.

更新日期：2007-01-01 00:00:00

abstract：:The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were examined in mice. BALB/c mice were sensitized by intraperitoneal ...

journal_title：Mediators of inflammation

authors： Asano K,Mizutani T,Shimane T,Hisano M,Hisamitsu T,Suzaki H

更新日期：2000-01-01 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:Interleukin-10 (IL-10) is a cytokine derived from CD4+ T-helper type 2 (T(H2)) cells identified as a suppressor of cytokines from T-helper type 1(T(H1)) cells. Interleukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates T(H1) cell differentiation, while suppressing the expan...

journal_title：Mediators of inflammation

authors： Chung F

更新日期：2001-04-01 00:00:00

abstract：:Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...

journal_title：Mediators of inflammation

authors： Miller MJ,Grisham MB

更新日期：1995-01-01 00:00:00

abstract：:Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...

journal_title：Mediators of inflammation

authors： Dalgėdienė I,Lučiūnaitė A,Žvirblienė A

更新日期：2018-11-18 00:00:00

abstract：:Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...

journal_title：Mediators of inflammation

authors： Park S,Park NY,Valacchi G,Lim Y

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Acute ST-segment elevation myocardial infarction (ASTEMI) is accompanied by increased expression of inflammation and decreased expression of anti-inflammation. IL-37 was found to be involved in the atherosclerosis-related diseases and increased in acute coronary syndrome. However, the level of IL-37 in blood ...

journal_title：Mediators of inflammation

authors： Wang X,Cai X,Chen L,Xu D,Li J

更新日期：2015-01-01 00:00:00

abstract：:Both alveolar macrophages (AMs) and alveolar epithelial cells (AECs) are main targets of Mycobacterium tuberculosis (M. tuberculosis (Mtb)). Intercellular communications between mucosal AECs and AMs have important implications in cellular responses to exogenous insults. However, molecular mechanisms underpinning inter...

journal_title：Mediators of inflammation

authors： Yang Y,Sun Y,Xu J,Bao K,Luo M,Liu X,Wang Y

更新日期：2018-09-26 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in ...

journal_title：Mediators of inflammation

authors： Ślebioda TJ,Kmieć Z

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised ...

journal_title：Mediators of inflammation

authors： Sallam N,Khazaei M,Laher I

更新日期：2010-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important ...

journal_title：Mediators of inflammation

authors： Bryan PF,Karla C,Edgar Alejandro MT,Sara Elva EP,Gemma F,Luz C

更新日期：2016-01-01 00:00:00