Abstract:
:Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in intestines and disruption of intestinal epithelial barrier. Members of the tumour necrosis factor superfamily (TNFSF) are molecules of broad spectrum of activity, including direct disruption of intestinal epithelial barrier integrity and costimulation of proinflammatory functions of lymphocytes. Tumour necrosis factor (TNF) has a well-established pathological role in IBD which also serves as a target in IBD treatment. In this review we discuss the role of TNF and other TNFSF members, notably, TL1A, FasL, LIGHT, TRAIL, and TWEAK, in the pathogenesis of IBD.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Ślebioda TJ,Kmieć Zdoi
10.1155/2014/325129subject
Has Abstractpub_date
2014-01-01 00:00:00pages
325129eissn
0962-9351issn
1466-1861journal_volume
2014pub_type
杂志文章,评审abstract::Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/146282
更新日期:2015-01-01 00:00:00
abstract::The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1155/2016/4739512
更新日期:2016-01-01 00:00:00
abstract::To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000153
更新日期:1994-01-01 00:00:00
abstract:Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/1936960
更新日期:2020-05-27 00:00:00
abstract::Thymosin beta(4) is a polypeptide isolated from thymosin fraction 5. This peptide exhibits important activities in the regulation and differentiation of thymus-dependent lymphocytes. An analogue of thymosin beta(4), [Phe(4F)(12)] deacetyl- thymosin beta(4), was synthesized by a solution method, followed by deprotectio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S096293519200019X
更新日期:1992-01-01 00:00:00
abstract::Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/2760272
更新日期:2018-09-20 00:00:00
abstract::Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosphate-activated protein ki...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/6209140
更新日期:2018-07-05 00:00:00
abstract::Systemic sclerosis (SSc) is an autoimmune connective tissue disorder of unknown etiology. This disease is characterized by a large variety of clinical patterns, which include the fibrosis of skin and visceral organs causing a variety of clinical manifestations. Genetic and environmental factors participate in the etio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/389582
更新日期:2014-01-01 00:00:00
abstract::The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/1094352
更新日期:2018-04-02 00:00:00
abstract::The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8360936
更新日期:2020-08-21 00:00:00
abstract::Invertebrates do not display the level of sophistication in immune reactivity characteristic of mammals and other 'higher' vertebrates. Their great number and diversity of forms, however, reflect their evolutionary success and hence they must have effective mechanisms of defence to deal with parasites and pathogens an...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000014
更新日期:1996-01-01 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/145293
更新日期:2015-01-01 00:00:00
abstract::Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/6039171
更新日期:2018-03-08 00:00:00
abstract:OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/958403
更新日期:2010-01-01 00:00:00
abstract::Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3120391
更新日期:2019-10-24 00:00:00
abstract::The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/380948
更新日期:2010-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/2989548
更新日期:2016-01-01 00:00:00
abstract::There is much evidence that degradation of the extracellular matrix is essential for the development of cholesteatomas and that this is induced by activation of matrix metalloproteinases (MMPs). Vitamin D3 (VD3) has several well-recognised biological activities, including suppression of MMP production. The present stu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.210
更新日期:2005-08-31 00:00:00
abstract::This study investigated whether the administration of resolvin D1 to rats with endotoxininduced uveitis (EIU) ameliorates the immuno-inflammatory profile of the eye. 24 h after the administration of 200 μg LPS into the footpad of Sprague-Dawley rats, severe changes of the structure of the eye occurred concomitantly wi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/318621
更新日期:2012-01-01 00:00:00
abstract::Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3952526
更新日期:2018-10-08 00:00:00
abstract::Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS). Studies have revealed that both early enteral nutrition (EEN) a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/29638
更新日期:2007-01-01 00:00:00
abstract::Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,收录出版
doi:10.1155/2018/4514329
更新日期:2018-04-05 00:00:00
abstract::Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anae...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.312
更新日期:2005-10-24 00:00:00
abstract::Postoperative-fluid retention is a severe complication frequently reported in patients undergoing major surgical procedures. The complex network of molecules involved in such a severe surgery-induced condition remains poorly understood. Inflammation has been proposed among the various causes of fluid retention. Since ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/159349
更新日期:2013-01-01 00:00:00
abstract::Statins exert pleiotropic effects on endothelial cells in addition to lowering cholesterol. 15-Lipoxygenase-1 (ALOX15) has been implicated in vascular inflammation and disease. The relationship between atorvastatin and ALOX15 was investigated using a rat carotid artery balloon-injury model. Hematoxylin and eosin (HE) ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/6769032
更新日期:2016-01-01 00:00:00
abstract::Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psor...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/7353420
更新日期:2019-05-28 00:00:00
abstract::Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA(4) on the expression of cyclooxygenase-2 in lipopolysaccharide-s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/745340
更新日期:2011-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2018/4514329.]. ...
journal_title:Mediators of inflammation
pub_type: 撤回出版物
doi:10.1155/2020/7859157
更新日期:2020-09-29 00:00:00
abstract::Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Different species of the genus Lactobacillus can evoke differe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/237921
更新日期:2013-01-01 00:00:00
abstract::Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data abou...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/3271579
更新日期:2016-01-01 00:00:00