TNF-α regulates natriuretic peptides and aquaporins in human bronchial epithelial cells BEAS-2B.

Abstract:

:Postoperative-fluid retention is a severe complication frequently reported in patients undergoing major surgical procedures. The complex network of molecules involved in such a severe surgery-induced condition remains poorly understood. Inflammation has been proposed among the various causes of fluid retention. Since TNF-α is one of the main proinflammatory cytokine initially released after major surgery, it is reasonable to assume its involvement in fluid overload. Here, we showed that TNF-α selectively regulates key molecules involved in fluids balance, such as natriuretic peptides (NPs) and aquaporins, in human bronchial epithelial cells BEAS-2B. In particular, we found that TNF-α induced a decrease of arial natriuretic peptide, natriuretic peptide receptor-1, aquaporin-1 and aquaporin-5 and an increase of brain natriuretic peptide with a different involvement of nuclear factor-κB and mitogen-activated protein kinases signaling pathway activation. Moreover, the observed changes in NPs expression, demonstrate inflammation as an additional cause of brain natriuretic peptide elevation, adding an important piece of information in the novel area of study regarding NPs and inflammation. Finally, we suggest that inflammation is one of the mechanisms of Aquaporin-1 and aquaporin-5 expression regulation. Therefore, in this exploratory study, we speculate that TNF-α might be involved in postoperative-fluid retention related to major surgery.

journal_name

Mediators Inflamm

authors

Mezzasoma L,Cagini L,Antognelli C,Puma F,Pacifico E,Talesa VN

doi

10.1155/2013/159349

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

159349

eissn

0962-9351

issn

1466-1861

journal_volume

2013

pub_type

杂志文章
  • The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast.

    abstract::Osteoarthritis (OA) belongs to a group of degenerative diseases. Synovial inflammation, cartilage abrasion, and subchondral sclerosis are characteristics of OA. Researchers do not fully understand the exact etiology of OA. However, matrix metalloproteinases (MMPs), which are responsible for cartilage matrix degradatio...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/759028

    authors: Chen YT,Hou CH,Hou SM,Liu JF

    更新日期:2014-01-01 00:00:00

  • The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia.

    abstract:INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/8045161

    authors: Bajnok A,Ivanova M,Rigó J Jr,Toldi G

    更新日期:2017-01-01 00:00:00

  • Chagas disease cardiomyopathy: immunopathology and genetics.

    abstract::Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop chronic Chagas disease cardiomyopathy (CCC), a particularly lethal inflammatory cardiomyopathy that occurs decades after the initial infection...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2014/683230

    authors: Cunha-Neto E,Chevillard C

    更新日期:2014-01-01 00:00:00

  • Circulating sCD138 and some angiogenesis-involved cytokines help to anticipate the disease progression of early-stage B-cell chronic lymphocytic leukemia.

    abstract::Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/MI/2006/42394

    authors: Wołowiec D,Dybko J,Wróbel T,Urbaniak-Kujda D,Jaźwiec B,Tomaszewska-Toporska B,Kapelko-Słowik K,Potoczek S,Kuliczkowski K

    更新日期:2006-01-01 00:00:00

  • Chemokines and chemokine receptors in multiple sclerosis.

    abstract::Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2014/659206

    authors: Cheng W,Chen G

    更新日期:2014-01-01 00:00:00

  • Tumour necrosis factor-alpha and adenosine in endotoxin shockleading related cardiovascular symptoms.

    abstract::We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-alpha,...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/S0962935195000731

    authors: Sipka S,Seres T,Dinya Z,Szekanecz Z,Szentmiklósi J,Bodolay E,Szegedi G

    更新日期:1995-01-01 00:00:00

  • Nitric oxide decreases intestinal haemorrhagic lesions in rat anaphylaxis independently of mast cell activation.

    abstract::The purpose of this study is to assess the role of nitric oxide (NO) in the intestinal lesions of passive anaphylaxis, since this experimental model resembles necrotizing enterocolitis. Sprague-Dawley rats were sensitized with IgE anti-dinitrophenol monoclonal antibody. Extravasation of protein-rich plasma and haemorr...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1080/09629359791893

    authors: Tavares JC,Moreno A,Crespo MS

    更新日期:1997-01-01 00:00:00

  • Tumor Necrosis Factor Alpha Inhibits L-Type Ca(2+) Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway.

    abstract::Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca(2+) channel (L-VDCC) current in cardiac myocytes, an observation that seems parado...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2016/5972302

    authors: Reyes-García J,Flores-Soto E,Solís-Chagoyán H,Sommer B,Díaz-Hernández V,García-Hernández LM,Montaño LM

    更新日期:2016-01-01 00:00:00

  • Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy.

    abstract:Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2018/5270657

    authors: Hou J,Zhang M,Ding Y,Wang X,Li T,Gao P,Jiang Y

    更新日期:2018-06-21 00:00:00

  • Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation.

    abstract::CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2016/8512417

    authors: Rotondi M,Coperchini F,Awwad O,Pignatti P,Di Buduo CA,Abbonante V,Magri F,Balduini A,Chiovato L

    更新日期:2016-01-01 00:00:00

  • Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway.

    abstract::Human gingival fibroblast barrier dysfunction caused by inflammation contributes to gingivitis and can lead to inflammatory periodontal disease. The disease features include upregulated epithelial permeability, increased inflammatory mediators, and downregulated junctional complex molecules. Carbon monoxide- (CO-) rel...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2020/6302391

    authors: Lv J,Liu Y,Jia S,Zhang Y,Tian H,Li J,Song H

    更新日期:2020-04-28 00:00:00

  • MiR-6803-5p Promotes Cancer Cell Proliferation and Invasion via PTPRO/NF-κB Axis in Colorectal Cancer.

    abstract::Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. Previously, we have found that exosome-encapsulated miR-6803-5p is increa...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/8128501

    authors: Yan S,Cheng M,Duan Q,Wang Z,Gao W,Ren B,Xu D

    更新日期:2019-11-20 00:00:00

  • The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics.

    abstract:BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/7918472

    authors: Liu Y,Liu T,Wu J,Li T,Jiao X,Zhang H,Zhao J,Wang J,Liu L,Cao L,Li S,Xu J,Xu J,Ma X,Yang L,Dong L

    更新日期:2017-01-01 00:00:00

  • Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in vitro.

    abstract::There is much evidence that degradation of the extracellular matrix is essential for the development of cholesteatomas and that this is induced by activation of matrix metalloproteinases (MMPs). Vitamin D3 (VD3) has several well-recognised biological activities, including suppression of MMP production. The present stu...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/MI.2005.210

    authors: Kobayashi H,Asano K,Kanai K,Suzaki H

    更新日期:2005-08-31 00:00:00

  • Calorie restriction with a high-fat diet effectively attenuated inflammatory response and oxidative stress-related markers in obese tissues of the high diet fed rats.

    abstract::Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2012/984643

    authors: Park S,Park NY,Valacchi G,Lim Y

    更新日期:2012-01-01 00:00:00

  • Proteinase-activated receptor-1 and immunomodulatory effects of a PAR1-activating peptide in a mouse model of prostatitis.

    abstract:BACKGROUND:Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. METHODS:Using a hapten (ethanol-dinitr...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2013/748395

    authors: Stanton MM,Nelson LK,Benediktsson H,Hollenberg MD,Buret AG,Ceri H

    更新日期:2013-01-01 00:00:00

  • No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis.

    abstract:BACKGROUND:Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS:In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS:Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1080/0962935031000097718

    authors: Denizot Y,Liozon E,Guglielmi L,Ly K,Soria P,Loustaud V,Vidal E,Jauberteau MO

    更新日期:2003-04-01 00:00:00

  • Bronchoalveolar lavage fluid IFN-γ+ Th17 cells and regulatory T cells in pulmonary sarcoidosis.

    abstract::In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3(+) CD4(+) T cell subsets in sarcoidosis remains unclear. Bronchoalveolar lavage fluid ce...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/438070

    authors: Tøndell A,Moen T,Børset M,Salvesen Ø,Rø AD,Sue-Chu M

    更新日期:2014-01-01 00:00:00

  • Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF-κB and MAPK Activation.

    abstract::In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/1897820

    authors: Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

    更新日期:2019-04-30 00:00:00

  • Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm.

    abstract::Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2015/606819

    authors: Fleischman AG

    更新日期:2015-01-01 00:00:00

  • Chemokine-ligands/receptors: multiplayers in traumatic spinal cord injury.

    abstract::Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/recept...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2015/486758

    authors: Knerlich-Lukoschus F,Held-Feindt J

    更新日期:2015-01-01 00:00:00

  • Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia.

    abstract::The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzy...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1080/0962935031000134888

    authors: Gora-Tybor J,Blonski JZ,Robak T

    更新日期:2003-06-01 00:00:00

  • CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway.

    abstract:Background:Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2020/4321912

    authors: Geng T,Yan Y,Zhang Y,Xu L,Zang G,Yan JC

    更新日期:2020-06-06 00:00:00

  • Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats.

    abstract::Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2020/2120971

    authors: Bao N,Dai D

    更新日期:2020-04-03 00:00:00

  • Macrophage trafficking as key mediator of adenine-induced kidney injury.

    abstract::Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition....

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/291024

    authors: Correa-Costa M,Braga TT,Felizardo RJ,Andrade-Oliveira V,Perez KR,Cuccovia IM,Hiyane MI,da Silva JS,Câmara NO

    更新日期:2014-01-01 00:00:00

  • Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases.

    abstract::Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identificati...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1851420

    authors: Thoudam T,Jeon JH,Ha CM,Lee IK

    更新日期:2016-01-01 00:00:00

  • Efficiency of double layered microencapsulated probiotic to modulate proinflammatory molecular markers for the management of alcoholic liver disease.

    abstract::Alcohol-related disorders are one of the challenging current health problems with medical, social, and economic consequences. Endotoxemia, oxidative stress, and release of a variety of inflammatory molecules are established mediators in alcoholic liver injury (ALD). Probiotics like L. plantarum though were reported to...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/715130

    authors: Arora S,Kaur IP,Chopra K,Rishi P

    更新日期:2014-01-01 00:00:00

  • Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring.

    abstract::Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). In rodents, MIA results in changes in cytokine profiles and abnormal behaviors in the offspring that model these neuropsychiatric conditions. Given the central role that mitochondria have in immunity ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2013/609602

    authors: Giulivi C,Napoli E,Schwartzer J,Careaga M,Ashwood P

    更新日期:2013-01-01 00:00:00

  • Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus.

    abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2010/792393

    authors: van den Oever IA,Raterman HG,Nurmohamed MT,Simsek S

    更新日期:2010-01-01 00:00:00

  • The possible role of the novel cytokines il-35 and il-37 in inflammatory bowel disease.

    abstract::Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and infla...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/136329

    authors: Li Y,Wang Y,Liu Y,Wang Y,Zuo X,Li Y,Lu X

    更新日期:2014-01-01 00:00:00