Abstract:
:Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1β and IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Zhao Y,Huang L,Xu H,Wu G,Zhu M,Tian J,Wang H,Wang X,Yu W,Yang L,Su Ddoi
10.1155/2016/3271579subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3271579eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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