Abstract:
:Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Pre-, peri-, and postoperative clinical data of the sepsis-positive (n = 85) and sepsis-negative (n = 41) groups were analyzed for potential risk factors of OLT-related sepsis. The sepsis-positive patients had a significantly higher rate of dialysis (49.4%), longer time under mechanical ventilation (1.5 d), higher hospitalization costs (0.41 million RMB), and worse survival rate (68.5%), compared with the sepsis-negative patients (4.8%, 1 d, 0.30 million RMB, and 73.1%, resp.). The multivariate logistic analysis identified the following as risk factors for OLT-related sepsis: preoperative Child-Pugh grade C (OR 10.43; 95% CI 2.081-52.292; P = 0.004), preoperative hypercalcemia (OR 6.372; 95% CI 1.693-23.98; P = 0.006), and perioperative acidosis (OR 6.364; 95% CI 1.196-33.869; P = 0.030). Patients with preoperative Child-Pugh grade C, preoperative hypercalcemia, or perioperative acidosis are at higher risk for developing sepsis after OLT. When any of these problems occur, timely sepsis management should be planned.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Wang Y,Gu Y,Huang F,Liu D,Zhang Z,Zhou N,Liang J,Lu C,Yuan D,Hei Zdoi
10.1155/2018/8703172subject
Has Abstractpub_date
2018-06-20 00:00:00pages
8703172eissn
0962-9351issn
1466-1861journal_volume
2018pub_type
杂志文章abstract::Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors incl...
journal_title:Mediators of inflammation
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abstract::[This corrects the article DOI: 10.1155/2019/2056085.]. ...
journal_title:Mediators of inflammation
pub_type: 已发布勘误
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/834153
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/748395
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journal_title:Mediators of inflammation
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doi:10.1155/2007/29638
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journal_title:Mediators of inflammation
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doi:10.1155/2019/7420468
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/971502
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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