Increased peripheral proinflammatory T helper subsets contribute to cardiovascular complications in diabetic patients.

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：OBJECTIVE:To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. METHODS:Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. The...

journal_title：Mediators of inflammation

authors： Zhao YJ,Li Q,Cheng BX,Zhang M,Chen YJ

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5(-/-)), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice. RESULTS:TLR5(-/-) and C57BL/6 male mice were divided into thre...

journal_title：Mediators of inflammation

authors： Wu SC,Rau CS,Lu TH,Tzeng SL,Wu YC,Wu CJ,Lin CW,Hsieh CH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...

journal_title：Mediators of inflammation

authors： López E,Zafra MP,Sastre B,Gámez C,Lahoz C,del Pozo V

更新日期：2011-01-01 00:00:00

abstract：Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...

journal_title：Mediators of inflammation

authors： Hou J,Zhang M,Ding Y,Wang X,Li T,Gao P,Jiang Y

更新日期：2018-06-21 00:00:00

abstract：:Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of further depletion. No biomarkers of fat mass alterations have been defi...

journal_title：Mediators of inflammation

authors： Ebadi M,Mazurak VC

更新日期：2015-01-01 00:00:00

abstract：Purpose:To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (...

journal_title：Mediators of inflammation

authors： Sheng J,Li T,Zhuang D,Cai S,Yang J,Ding F,Chen X,Tian F,Huang M,Li L,Li K,Chen W

更新日期：2020-12-28 00:00:00

abstract：:Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 pa...

journal_title：Mediators of inflammation

authors： Denizot Y,Fixe P,Cornu E,Nathan N

更新日期：1996-01-01 00:00:00

abstract：Background:Acute lung injury (ALI) and subsequent pulmonary infection are the most severe and usually fatal complications for elderly hip fracture patients. It is necessary to find some biomarkers for early diagnosis and prognosis of it. Objective:This study is aimed at examining the differential expression of miR-146...

journal_title：Mediators of inflammation

authors： Gan L,Sun T,Li B,Tian J,Zhang J,Chen X,Zhong J,Yang X,Li Q

更新日期：2018-10-28 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00

abstract：:Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for...

journal_title：Mediators of inflammation

authors： Masekela R,Green RJ

更新日期：2012-01-01 00:00:00

abstract：:Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...

journal_title：Mediators of inflammation

authors： Bao N,Dai D

更新日期：2020-04-03 00:00:00

abstract：:Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition....

journal_title：Mediators of inflammation

authors： Correa-Costa M,Braga TT,Felizardo RJ,Andrade-Oliveira V,Perez KR,Cuccovia IM,Hiyane MI,da Silva JS,Câmara NO

更新日期：2014-01-01 00:00:00

abstract：:Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investiga...

journal_title：Mediators of inflammation

authors： Oh SJ,Park HY,Choi KU,Choi SW,Kim SD,Kong SK,Cho KS

更新日期：2018-03-18 00:00:00

abstract：:Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorph...

journal_title：Mediators of inflammation

authors： Aljarba NH,Al-Anazi MR,Shafeai MI,Rudiny FH,Bin Dajem SM,Alothaid H,Darraj M,Alkahtani S,Alghamdi J,Al-Ahdal MN,Al-Qahtani AA

更新日期：2020-02-19 00:00:00

abstract：:Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...

journal_title：Mediators of inflammation

authors： Dunne MR,Mangan BA,Madrigal-Estebas L,Doherty DG

更新日期：2010-01-01 00:00:00

abstract：:The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...

journal_title：Mediators of inflammation

authors： Lemos Vde A,dos Santos RV,Lira FS,Rodrigues B,Tufik S,de Mello MT

更新日期：2013-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a major worldwide health problem. Chronic infection induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual cirrhosis, and possible hepatocellular carcinoma. Eradication of the virus is one of the most important treatment aims. A number of promising ...

journal_title：Mediators of inflammation

authors： Tamori A,Enomoto M,Kawada N

更新日期：2016-01-01 00:00:00

abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

journal_title：Mediators of inflammation

authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

journal_title：Mediators of inflammation

authors： Bajnok A,Ivanova M,Rigó J Jr,Toldi G

更新日期：2017-01-01 00:00:00

abstract：:To elucidate the role of (1-->3)-beta-D-glucan in pulmonary aspergilloma, serum concentrations of (1-->3)-beta-D-glucan were measured repeatedly for as long as 10 months in eight patients. In four patients with inactive disease, concentrations of (1-->3)-beta-D-glucan were in the normal range.The concentrations of (1-...

journal_title：Mediators of inflammation

authors： Yuasa K,Goto H

更新日期：1997-01-01 00:00:00

abstract：:Background. Patients with UC have shown an important defect in the secretion and maintenance of the mucosal barrier as part of inadequate expression of mucin genes. The aim of the present study was to determine the expression of MUC12, MUC16, and MUC20 in colonic tissue from patients with UC in regard to their clinica...

journal_title：Mediators of inflammation

authors： Yamamoto-Furusho JK,Ascaño-Gutiérrez I,Furuzawa-Carballeda J,Fonseca-Camarillo G

更新日期：2015-01-01 00:00:00

abstract：:Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...

journal_title：Mediators of inflammation

authors： Park S,Park NY,Valacchi G,Lim Y

更新日期：2012-01-01 00:00:00

abstract：:Periodontitis is a kind of chronic inflammatory disease that affects the tooth-supporting tissues. ET-1 is related to periodontitis and involved in the regulation of cytokines, but the mechanisms remain unclear. The aim of this study is to investigate how ET-1 affects proinflammatory cytokine expression and differenti...

journal_title：Mediators of inflammation

authors： Liang L,Zhou W,Yang N,Yu J,Liu H

更新日期：2016-01-01 00:00:00

abstract：:Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems and in conditions of neuropa...

journal_title：Mediators of inflammation

authors： Ramesh G,MacLean AG,Philipp MT

更新日期：2013-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display signi...

journal_title：Mediators of inflammation

authors： Yin G,Wang Y,Cen XM,Yang M,Liang Y,Xie QB

更新日期：2015-01-01 00:00:00

abstract：:Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a c...

journal_title：Mediators of inflammation

authors： Puccetti M,Paolicelli G,Oikonomou V,De Luca A,Renga G,Borghi M,Pariano M,Stincardini C,Scaringi L,Giovagnoli S,Ricci M,Romani L,Zelante T

更新日期：2018-02-18 00:00:00

abstract：:Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 c...

journal_title：Mediators of inflammation

authors： Bystrom J,Taher TE,Muhyaddin MS,Clanchy FI,Mangat P,Jawad AS,Williams RO,Mageed RA

更新日期：2015-01-01 00:00:00

abstract：:Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contrib...

journal_title：Mediators of inflammation

authors： Stunault MI,Bories G,Guinamard RR,Ivanov S

更新日期：2018-12-10 00:00:00

abstract：:Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...

journal_title：Mediators of inflammation

authors： Dente FL,Bilotta M,Bartoli ML,Bacci E,Cianchetti S,Latorre M,Malagrinò L,Nieri D,Roggi MA,Vagaggini B,Paggiaro P

更新日期：2015-01-01 00:00:00