Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis.

abstract：:With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understa...

journal_title：Mediators of inflammation

authors： Lu J,Xiong L,Zhang X,Liu Z,Wang S,Zhang C,Zheng J,Wang G,Zheng R,Simpson JL,Wang F

更新日期：2017-01-01 00:00:00

abstract：:In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

journal_title：Mediators of inflammation

authors： Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

更新日期：2019-04-30 00:00:00

abstract：:A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance...

journal_title：Mediators of inflammation

authors： Lopalco G,Cantarini L,Vitale A,Iannone F,Anelli MG,Andreozzi L,Lapadula G,Galeazzi M,Rigante D

更新日期：2015-01-01 00:00:00

abstract：:Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors. The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice. Mice were pretreated with OA-NO...

journal_title：Mediators of inflammation

authors： Wang H,Jia Z,Sun J,Xu L,Zhao B,Yu K,Yang M,Yang T,Wang R

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...

journal_title：Mediators of inflammation

authors： Noguchi T,Sado T,Naruse K,Shigetomi H,Onogi A,Haruta S,Kawaguchi R,Nagai A,Tanase Y,Yoshida S,Kitanaka T,Oi H,Kobayashi H

更新日期：2010-01-01 00:00:00

abstract：:Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of th...

journal_title：Mediators of inflammation

authors： Marcusso Orsini T,Kawakami NY,Panis C,Fortes Dos Santos Thomazelli AP,Tomiotto-Pellissier F,Cataneo AH,Kian D,Megumi Yamauchi L,Gouveia Júnior FS,de França Lopes LG,Cecchini R,Nazareth Costa I,Jerley Nogueira da Silva J,Conchon

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Influenza virus is a worldwide health problem with significant economic consequences. To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study. AIMS:To assess...

journal_title：Mediators of inflammation

authors： Sakai S,Mantani N,Kogure T,Ochiai H,Shimada Y,Terasawa K

更新日期：2002-12-01 00:00:00

abstract：:Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the regulation of the ant...

journal_title：Mediators of inflammation

authors： Makeeva A,Rodriguez-Montesinos J,Zelenikhin P,Nesmelov A,Preissner KT,Cabrera-Fuentes HA,Ilinskaya ON

更新日期：2017-01-01 00:00:00

abstract：:Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...

journal_title：Mediators of inflammation

authors： Kazama I

更新日期：2015-01-01 00:00:00

abstract：:The aim was to investigate whether bone tissue resorption in early RA is related to crepitus of the temporomandibular joint (TMJ) and systemic levels of inflammatory mediators and markers and sex steroid hormones. Twentynine women and 18 men with recently diagnosed RA were examined for TMJ bone erosions with computeri...

journal_title：Mediators of inflammation

authors： Hajati AK,Näsström K,Alstergren P,Bratt J,Kopp S

更新日期：2010-01-01 00:00:00

abstract：:There is much evidence that degradation of the extracellular matrix is essential for the development of cholesteatomas and that this is induced by activation of matrix metalloproteinases (MMPs). Vitamin D3 (VD3) has several well-recognised biological activities, including suppression of MMP production. The present stu...

journal_title：Mediators of inflammation

authors： Kobayashi H,Asano K,Kanai K,Suzaki H

更新日期：2005-08-31 00:00:00

abstract：:Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important ...

journal_title：Mediators of inflammation

authors： Bryan PF,Karla C,Edgar Alejandro MT,Sara Elva EP,Gemma F,Luz C

更新日期：2016-01-01 00:00:00

abstract：:To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...

journal_title：Mediators of inflammation

authors： Song HT,Qin Y,Yao GD,Tian ZN,Fu SB,Geng JS

更新日期：2014-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

journal_title：Mediators of inflammation

authors： Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

更新日期：2011-01-01 00:00:00

abstract：:Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods...

journal_title：Mediators of inflammation

authors： Ying F,Cunjing Z,Feng F,Shuo W,Xin Z,Fukang X,Zhongdao W

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...

journal_title：Mediators of inflammation

authors： Cerezo LA,Kuklová M,Hulejová H,Vernerová Z,Kaspříková N,Veigl D,Pavelka K,Vencovský J,Šenolt L

更新日期：2015-01-01 00:00:00

abstract：:The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...

journal_title：Mediators of inflammation

authors： Vaillier D,Daculsi R,Gualdel N

更新日期：1996-01-01 00:00:00

abstract：:A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute ...

journal_title：Mediators of inflammation

authors： Juczynska K,Wozniacka A,Waszczykowska E,Danilewicz M,Wagrowska-Danilewicz M,Wieczfinska J,Pawliczak R,Zebrowska A

更新日期：2017-01-01 00:00:00

abstract：AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...

journal_title：Mediators of inflammation

authors： Basyigit I,Yildiz F,Ozkara SK,Boyaci H,Ilgazli A

更新日期：2004-08-01 00:00:00

abstract：:Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...

journal_title：Mediators of inflammation

authors： Hernández-Aguilera A,Fernández-Arroyo S,Cabre N,Luciano-Mateo F,Baiges-Gaya G,Fibla M,Martín-Paredero V,Menendez JA,Camps J,Joven J

更新日期：2018-09-20 00:00:00

abstract：:Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...

journal_title：Mediators of inflammation

authors： Wang ZY,Zhang JA,Wu XJ,Liang YF,Lu YB,Gao YC,Dai YC,Yu SY,Jia Y,Fu XX,Rao X,Xu JF,Zhong J

更新日期：2016-01-01 00:00:00

abstract：:Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...

journal_title：Mediators of inflammation

authors： Karamanolis G,Delladetsima I,Kouloulias V,Papaxoinis K,Panayiotides I,Haldeopoulos D,Triantafyllou K,Kelekis N,Ladas SD

更新日期：2013-01-01 00:00:00

abstract：:Inflammatory processes are known to be involved at least in the early phase of complex regional pain syndrome type 1 (CRPS1). Blister fluid obtained from the involved extremities displayed increased amounts of proinflammatory cytokines IL-6 and TNFalpha compared with the noninvolved extremities. The aim of this paper ...

journal_title：Mediators of inflammation

authors： Heijmans-Antonissen C,Wesseldijk F,Munnikes RJ,Huygen FJ,van der Meijden P,Hop WC,Hooijkaas H,Zijlstra FJ

更新日期：2006-01-01 00:00:00

abstract：:Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and ...

journal_title：Mediators of inflammation

authors： Wang J,Zhao P,Guo H,Sun X,Jiang Z,Xu L,Feng J,Niu J,Jiang Y

更新日期：2012-01-01 00:00:00

abstract：:Fibrosis of oesophagus, lungs, heart, and kidney in the course of systemic sclerosis (SSc) may lead to dysfunction of the above organs or even patients death. Recent studies point out the role of angiogenesis and fibrosis disturbances in the pathogenesis of SSc. Heart fibrosis is one of the most important prognostic f...

journal_title：Mediators of inflammation

authors： Dziankowska-Bartkowiak B,Waszczykowska E,Zalewska A,Sysa-Jedrzejowska A

更新日期：2005-08-14 00:00:00

abstract：:The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzy...

journal_title：Mediators of inflammation

authors： Gora-Tybor J,Blonski JZ,Robak T

更新日期：2003-06-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/3809092.]. ...

journal_title：Mediators of inflammation

authors： Curtiss E,Jiang Y,Liu L,Hawthorne C,Zhang J,Steinle JJ

更新日期：2019-06-18 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：:Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 c...

journal_title：Mediators of inflammation

authors： Bystrom J,Taher TE,Muhyaddin MS,Clanchy FI,Mangat P,Jawad AS,Williams RO,Mageed RA

更新日期：2015-01-01 00:00:00

abstract：:Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml(-1). The clinical outcome correlated with the level of tumour necrosis factor alpha (...

journal_title：Mediators of inflammation

authors： Endo S,Inada K,Inoue Y,Otsu T,Kasai T,Kuwata Y,Hoshi S,Yoshida M

更新日期：1992-01-01 00:00:00