Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling.

abstract：:Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...

journal_title：Mediators of inflammation

authors： Dente FL,Bilotta M,Bartoli ML,Bacci E,Cianchetti S,Latorre M,Malagrinò L,Nieri D,Roggi MA,Vagaggini B,Paggiaro P

更新日期：2015-01-01 00:00:00

abstract：:Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of further depletion. No biomarkers of fat mass alterations have been defi...

journal_title：Mediators of inflammation

authors： Ebadi M,Mazurak VC

更新日期：2015-01-01 00:00:00

abstract：:The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-...

journal_title：Mediators of inflammation

authors： Akarsu S,Kurt AN,Dogan Y,Yilmaz E,Godekmerdan A,Aygun AD

更新日期：2005-02-24 00:00:00

abstract：BACKGROUND:This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5(-/-)), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice. RESULTS:TLR5(-/-) and C57BL/6 male mice were divided into thre...

journal_title：Mediators of inflammation

authors： Wu SC,Rau CS,Lu TH,Tzeng SL,Wu YC,Wu CJ,Lin CW,Hsieh CH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS:We employed a chemiluminescence immunoas...

journal_title：Mediators of inflammation

authors： De Giglio L,Marinelli F,Prosperini L,Contessa GM,Gurreri F,Piattella MC,De Angelis F,Barletta VT,Tomassini V,Pantano P,Pozzilli C

更新日期：2015-01-01 00:00:00

abstract：:Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...

journal_title：Mediators of inflammation

authors： Yan X,Xie B,Wu G,Hu J,Wang D,Cai X,Li J

更新日期：2019-01-08 00:00:00

abstract：:[This retracts the article DOI: 10.1155/2018/4514329.]. ...

journal_title：Mediators of inflammation

authors： Of Inflammation M

更新日期：2020-09-29 00:00:00

abstract：:We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys admini...

journal_title：Mediators of inflammation

authors： Lomakin Y,Belogurov A Jr,Glagoleva I,Stepanov A,Zakharov K,Okunola J,Smirnov I,Genkin D,Gabibov A

更新日期：2016-01-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data abou...

journal_title：Mediators of inflammation

authors： Zhao Y,Huang L,Xu H,Wu G,Zhu M,Tian J,Wang H,Wang X,Yu W,Yang L,Su D

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoar...

journal_title：Mediators of inflammation

authors： Gelderman MP,Stuart R,Vigerust D,Fuhrmann S,Lefkowitz DL,Allen RC,Lefkowitz SS,Graham S

更新日期：1998-01-01 00:00:00

abstract：:Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorph...

journal_title：Mediators of inflammation

authors： Aljarba NH,Al-Anazi MR,Shafeai MI,Rudiny FH,Bin Dajem SM,Alothaid H,Darraj M,Alkahtani S,Alghamdi J,Al-Ahdal MN,Al-Qahtani AA

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...

journal_title：Mediators of inflammation

authors： Brandt C,Pedersen M,Rinnov A,Andreasen AS,Møller K,Hojman P,Pedersen BK,Plomgaard P

更新日期：2014-01-01 00:00:00

abstract：:Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...

journal_title：Mediators of inflammation

authors： Wang J,Li Y,Zhao P,Tian Y,Liu X,He H,Jia R,Oliver BG,Li J

更新日期：2020-05-08 00:00:00

abstract：AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...

journal_title：Mediators of inflammation

authors： Basyigit I,Yildiz F,Ozkara SK,Boyaci H,Ilgazli A

更新日期：2004-08-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...

journal_title：Mediators of inflammation

authors： Bolton C,Paul C

更新日期：2006-01-01 00:00:00

abstract：:Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock. Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical ...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Rosenhagen C,Krauser U,Mieth M,Bruckner T,Martin E,Nawroth PP,Weigand MA,Bierhaus A,Hofer S

更新日期：2012-01-01 00:00:00

abstract：:Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...

journal_title：Mediators of inflammation

authors： Oviedo-Boyso J,Bravo-Patiño A,Baizabal-Aguirre VM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. METHODS:Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-a...

journal_title：Mediators of inflammation

authors： Kartal Durmazlar SP,Akgul A,Eskioglu F

更新日期：2008-01-01 00:00:00

abstract：:The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...

journal_title：Mediators of inflammation

authors： Matsushita K,Takeoka M,Sagara J,Itano N,Kurose Y,Nakamura A,Taniguchi S

更新日期：2009-01-01 00:00:00

abstract：:TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activ...

journal_title：Mediators of inflammation

authors： DeSantis DA,Ko CW,Wang L,Lee P,Croniger CM

更新日期：2015-01-01 00:00:00

abstract：:As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...

journal_title：Mediators of inflammation

authors： Liu C,Li Y,Chen Y,Huang S,Wang X,Luo S,Su Y,Zhou L,Luo X

更新日期：2020-10-05 00:00:00

abstract：:Both alveolar macrophages (AMs) and alveolar epithelial cells (AECs) are main targets of Mycobacterium tuberculosis (M. tuberculosis (Mtb)). Intercellular communications between mucosal AECs and AMs have important implications in cellular responses to exogenous insults. However, molecular mechanisms underpinning inter...

journal_title：Mediators of inflammation

authors： Yang Y,Sun Y,Xu J,Bao K,Luo M,Liu X,Wang Y

更新日期：2018-09-26 00:00:00

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

journal_title：Mediators of inflammation

authors： Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

更新日期：2019-04-30 00:00:00

abstract：AIM:To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. METHODS:Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided i...

journal_title：Mediators of inflammation

authors： Doğan Y,Erkan T,Önal Z,Usta M,Doğusoy G,Çokuğraş FÇ,Kutlu T

更新日期：2012-01-01 00:00:00

abstract：:The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...

journal_title：Mediators of inflammation

authors： Wei Y,Liu S,Yu H,Zhang Y,Gao W,Cui M,Li L

更新日期：2020-08-21 00:00:00

abstract：:Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction. The inflammatory mediator Krüppel-like factor 4 is upregulated during inflammation and plays an important role in en...

journal_title：Mediators of inflammation

authors： Luo X,Chen J,Ruan J,Chen Y,Mo X,Xie J,Lv G

更新日期：2016-01-01 00:00:00

abstract：:The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...

journal_title：Mediators of inflammation

authors： Vaillier D,Daculsi R,Gualdel N

更新日期：1996-01-01 00:00:00

abstract：:Observation of the microcirculation of the hamster cheek pouch by intravital microscopy revealed five steps of neutrophil migration from the venules after topical application of leukotriene B(4) to the microvasculature: rolling along the venular wall (Step 1), adhesion to it (Step 2), disappearance from the vascular l...

journal_title：Mediators of inflammation

authors： Oda T,Katori M,Hatanaka K,Nagai Y

更新日期：1995-01-01 00:00:00

abstract：:Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients w...

journal_title：Mediators of inflammation

authors： Lenglet S,Quercioli A,Fabre M,Galan K,Pelli G,Nencioni A,Bauer I,Pende A,Python M,Bertolotto M,Spinella G,Pane B,Palombo D,Dallegri F,Mach F,Vuilleumier N,Montecucco F

更新日期：2014-01-01 00:00:00