The differential diagnostic values of cytokine levels in pleural effusions.

abstract：PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...

journal_title：Mediators of inflammation

authors： Pawlowski P,Reszec J,Eckstein A,Johnson K,Grzybowski A,Chyczewski L,Mysliwiec J

更新日期：2014-01-01 00:00:00

abstract：:Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...

journal_title：Mediators of inflammation

authors： Bao N,Dai D

更新日期：2020-04-03 00:00:00

abstract：:The carrageenan pleurisy model, which is characterized by cellular influx and oedema, has been used to examine the effects of anti-inflammatory compounds such as naproxen. Interleukin-1alpha and beta (IL-1) are known to be pro-inflammatory mediators, and their roles in this model are unknown. Intrapleural injection of...

journal_title：Mediators of inflammation

authors： Goodman R,Mantegna LR,McAilister CL,Bruin E,Dowling RL,George H,Feeser W,Freimark B,Lischwe M,Pick S,Harris RR,Kerr JS

更新日期：1993-01-01 00:00:00

abstract：:Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, part...

journal_title：Mediators of inflammation

authors： Kirschneck C,Küchler EC,Wolf M,Spanier G,Proff P,Schröder A

更新日期：2019-03-10 00:00:00

abstract：:Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...

journal_title：Mediators of inflammation

authors： Wołowiec D,Dybko J,Wróbel T,Urbaniak-Kujda D,Jaźwiec B,Tomaszewska-Toporska B,Kapelko-Słowik K,Potoczek S,Kuliczkowski K

更新日期：2006-01-01 00:00:00

abstract：:Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...

journal_title：Mediators of inflammation

authors： Vaswani K,Chan HW,Peiris HN,Nitert MD,Bradley RJ,Armitage JA,Rice GE,Mitchell MD

更新日期：2015-01-01 00:00:00

abstract：:Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...

journal_title：Mediators of inflammation

authors： Miller MJ,Grisham MB

更新日期：1995-01-01 00:00:00

abstract：:The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...

journal_title：Mediators of inflammation

authors： Safrankova B,Gajdova S,Kubala L

更新日期：2010-01-01 00:00:00

abstract：:Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and ...

journal_title：Mediators of inflammation

authors： Wang J,Zhao P,Guo H,Sun X,Jiang Z,Xu L,Feng J,Niu J,Jiang Y

更新日期：2012-01-01 00:00:00

abstract：:Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...

journal_title：Mediators of inflammation

authors： Yan X,Xie B,Wu G,Hu J,Wang D,Cai X,Li J

更新日期：2019-01-08 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in ...

journal_title：Mediators of inflammation

authors： Ślebioda TJ,Kmieć Z

更新日期：2014-01-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics me...

journal_title：Mediators of inflammation

authors： Liu D,Mao P,Huang Y,Liu Y,Liu X,Pang X,Li Y

更新日期：2014-01-01 00:00:00

abstract：:An underlying endothelial dysfunction plays a fundamental role in the pathogenesis of cardiovascular events and is the central feature of atherosclerosis. The protein-based communication between leukocytes and inflamed endothelial cells leading to diapedesis has been largely investigated and several key players such a...

journal_title：Mediators of inflammation

authors： Dorosz SA,Ginolhac A,Kähne T,Naumann M,Sauter T,Salsmann A,Bueb JL

更新日期：2015-01-01 00:00:00

abstract：:This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, a...

journal_title：Mediators of inflammation

authors： Zhou PH,Hu W,Zhang XB,Wang W,Zhang LJ

更新日期：2016-01-01 00:00:00

abstract：:Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...

journal_title：Mediators of inflammation

authors： Branco ACCC,Yoshikawa FSY,Pietrobon AJ,Sato MN

更新日期：2018-08-27 00:00:00

abstract：:It has been suggested that the supernatant of LPSstimulated macrophages (macrophage nociceptive factor, MNF) promotes nociception in mice. Intraperitoneal administration of MNF induced dose-related writhing, which reached a plateau between 18 and 26 min after injection and decreased within 60 min. The release of MNF w...

journal_title：Mediators of inflammation

authors： Thomazzi SM,Ribeiro RA,Campos DI,Cunha FQ,Ferreira SH

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans. In this study, we investigated the influence of cardiovascular risk factors on the expression of the PGE2 pathway in human AAA...

journal_title：Mediators of inflammation

authors： Dilmé JF,Solà-Villà D,Bellmunt S,Romero JM,Escudero JR,Camacho M,Vila L

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...

journal_title：Mediators of inflammation

authors： Hamzaoui A,Hamzaoui K,Kahan A,Chabbou A

更新日期：1996-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...

journal_title：Mediators of inflammation

authors： Sedda S,Marafini I,Figliuzzi MM,Pallone F,Monteleone G

更新日期：2014-01-01 00:00:00

abstract：:Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...

journal_title：Mediators of inflammation

authors： Kazama I

更新日期：2015-01-01 00:00:00

abstract：:To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and...

journal_title：Mediators of inflammation

authors： Mascarenhas-Melo F,Sereno J,Teixeira-Lemos E,Marado D,Palavra F,Pinto R,Rocha-Pereira P,Teixeira F,Reis F

更新日期：2013-01-01 00:00:00

abstract：:The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...

journal_title：Mediators of inflammation

authors： Vaillier D,Daculsi R,Gualdel N

更新日期：1996-01-01 00:00:00

abstract：:S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...

journal_title：Mediators of inflammation

authors： Lovati AB,Drago L,Bottagisio M,Bongio M,Ferrario M,Perego S,Sansoni V,De Vecchi E,Romanò CL

更新日期：2016-01-01 00:00:00

abstract：:Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...

journal_title：Mediators of inflammation

authors： Hernández-Aguilera A,Fernández-Arroyo S,Cabre N,Luciano-Mateo F,Baiges-Gaya G,Fibla M,Martín-Paredero V,Menendez JA,Camps J,Joven J

更新日期：2018-09-20 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common respiratory virus and is associated with pediatric pneumonia, causing bronchiolitis and significant mortality in infants and young children. MicroRNAs (miRNAs) are endogenous noncoding small RNAs that function in gene regulation and are associated with host immune r...

journal_title：Mediators of inflammation

authors： Zhang X,Huang F,Yang D,Peng T,Lu G

更新日期：2020-05-01 00:00:00

abstract：:The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammato...

journal_title：Mediators of inflammation

authors： Fuentes E,Fuentes F,Vilahur G,Badimon L,Palomo I

更新日期：2013-01-01 00:00:00

abstract：:The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-deri...

journal_title：Mediators of inflammation

authors： Alvarez Y,Valera I,Municio C,Hugo E,Padrón F,Blanco L,Rodríguez M,Fernández N,Crespo MS

更新日期：2010-01-01 00:00:00

abstract：:Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA(4) on the expression of cyclooxygenase-2 in lipopolysaccharide-s...

journal_title：Mediators of inflammation

authors： Zheng S,Wang Q,He Q,Song X,Ye D,Gao F,Jin S,Lian Q

更新日期：2011-01-01 00:00:00

abstract：:The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macro...

journal_title：Mediators of inflammation

authors： Boudjeltia KZ,Delporte C,Van Antwerpen P,Franck T,Serteyn D,Moguilevsky N,Raes M,Vanhamme L,Vanhaeverbeek M,Van Meerhaeghe A,Roumeguère T

更新日期：2013-01-01 00:00:00

abstract：:Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signal...

journal_title：Mediators of inflammation

authors： Di Salvo E,Ventura-Spagnolo E,Casciaro M,Navarra M,Gangemi S

更新日期：2018-03-11 00:00:00