Abstract:
:Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). We contend that there is ample evidence to consider nitric oxide as a molecular aggressor in inflammation, particularly chronic inflammation. Therapeutic benefit can be achieved by inhibition of inducible nitric oxide synthase and not the donation of additional nitric oxide. Furthermore, there is growing appreciation that nitric oxide and products derived thereof, are critical components linking the increased incidence of cancer in states of chronic inflammation.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Miller MJ,Grisham MBdoi
10.1155/S0962935195000639subject
Has Abstractpub_date
1995-01-01 00:00:00pages
387-96issue
6eissn
0962-9351issn
1466-1861journal_volume
4pub_type
杂志文章abstract:Purpose:To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5483981
更新日期:2020-12-28 00:00:00
abstract::Periploca forrestii Schltr. has been used as a Chinese folk medicine due to its versatile pharmacological effects such as promoting wounds and rheumatoid arthritis. However, the antiarthritic activity of Periploca forrestii saponin (PFS) and its active compound Periplocin has still not been demonstrated. Here, we eval...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7941684
更新日期:2016-01-01 00:00:00
abstract::In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production ofcytokines and to in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000591
更新日期:1994-01-01 00:00:00
abstract::Behçet's disease (BD) is a multisystemic disorder of unknown etiology characterized by the "triple symptom complex" consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis. Recurrent mucocutaneous lesions are generally considered the hallmark of the disease, being the most commo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/451675
更新日期:2015-01-01 00:00:00
abstract::TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/909827
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. METHODS:The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group. Myocardial infarct size, markers of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/1232103
更新日期:2016-01-01 00:00:00
abstract::Group A streptococcus (GAS) imposes a great burden on humans. Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3 β (GSK-3 β) is known to regulate inflammatory response in infectious diseases. However, the regulation of GSK-3 β in GAS infection is still unk...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/720689
更新日期:2013-01-01 00:00:00
abstract::Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/850471
更新日期:2015-01-01 00:00:00
abstract::Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3738409
更新日期:2019-11-14 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/145293
更新日期:2015-01-01 00:00:00
abstract::Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors incl...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/7570452
更新日期:2019-11-12 00:00:00
abstract::This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124118
更新日期:2001-08-01 00:00:00
abstract::A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020002930
更新日期:2000-01-01 00:00:00
abstract::Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4260204
更新日期:2020-05-08 00:00:00
abstract::We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-alpha,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000731
更新日期:1995-01-01 00:00:00
abstract::Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. Previously, we have found that exosome-encapsulated miR-6803-5p is increa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/8128501
更新日期:2019-11-20 00:00:00
abstract::Type 2 Diabetes Mellitus (T2DM) is well known to include an inflammatory component that has been considered to be related to diabetic complications. Diabetic nephropathy (DN) is one of the significant complications as it constitutes the most frequent cause of end-stage renal disease. Tumor Necrosis Factor-α (TNF-α) is...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/1498278
更新日期:2020-07-01 00:00:00
abstract::Behçet's disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways. The objective of this study was to investigate the association of the DC stimulatory molecu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/5761392
更新日期:2019-09-09 00:00:00
abstract:OBJECTIVES:In the present study, the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to stimulate osteoblast function and inhibit the release of bone-resorbing mediators was investigated in osteoblastic MC3T3-E1 cells. METHODS:Osteoblast function was measured by cell growth, a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/829650
更新日期:2012-01-01 00:00:00
abstract::A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6716419
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8045161
更新日期:2017-01-01 00:00:00
abstract::The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/287387
更新日期:2009-01-01 00:00:00
abstract::Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosphate-activated protein ki...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/6209140
更新日期:2018-07-05 00:00:00
abstract::The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000292
更新日期:1992-01-01 00:00:00
abstract::We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000330
更新日期:1995-01-01 00:00:00
abstract::CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8512417
更新日期:2016-01-01 00:00:00
abstract::Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/167572
更新日期:2015-01-01 00:00:00
abstract::Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4316316
更新日期:2017-01-01 00:00:00
abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/792393
更新日期:2010-01-01 00:00:00
abstract::Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3513651
更新日期:2017-01-01 00:00:00