Abstract:
:TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activation of the Nlrc4 inflammasome may lead to induced hepatocyte proliferation and prevent the development of hepatic fibrosis. The gene of Nlrc4 contains two single nucleotide polymorphisms (SNPs), one located within the Nlrc4 promoter and one contained within exon 5. These SNPs regulate Nlrc4 gene transcription and activation as measured through gene reporter assays and IL-1β secretion. The 17C-6 mice have increased IL-1β in plasma after chronic carbon tetrachloride (CCl4) administration compared to B6 mice. After two-thirds partial hepatectomy (2/3PH) 17C-6 mice have earlier restoration of liver mass with greater cyclin D1 protein and BrdU incorporation compared to B6 mice at several time points. These data reveal mild constitutive activation of the Nlrc4 inflammasome as the results of two SNPs, which leads to the stimulation of hepatocyte proliferation. The increased liver regeneration induces rapid liver mass recovery after hepatectomy and may prevent the development of hepatotoxin-induced liver fibrosis.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
DeSantis DA,Ko CW,Wang L,Lee P,Croniger CMdoi
10.1155/2015/909827subject
Has Abstractpub_date
2015-01-01 00:00:00pages
909827eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
杂志文章abstract::Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/515048
更新日期:2013-01-01 00:00:00
abstract::It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/823486
更新日期:2010-01-01 00:00:00
abstract::Behçet's disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways. The objective of this study was to investigate the association of the DC stimulatory molecu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/5761392
更新日期:2019-09-09 00:00:00
abstract::Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; correc...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/432575
更新日期:2012-01-01 00:00:00
abstract:Objective:Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods:Rat RI/RI models were constructed by surgical ope...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8869511
更新日期:2020-11-24 00:00:00
abstract::Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues. In inflamed tissues, superoxide is produced by the phagocytic NOX2 complex, which consists of the catalytic sub...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/730469
更新日期:2012-01-01 00:00:00
abstract::Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple cytokines. Although dysregulation of interleukin- (IL-) 22 is invol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/209179
更新日期:2013-01-01 00:00:00
abstract::With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understa...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/3890601
更新日期:2017-01-01 00:00:00
abstract::The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1155/2016/4739512
更新日期:2016-01-01 00:00:00
abstract::The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were examined in mice. BALB/c mice were sensitized by intraperitoneal ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/096293500411532
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/740357
更新日期:2015-01-01 00:00:00
abstract::Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anae...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.312
更新日期:2005-10-24 00:00:00
abstract:INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8045161
更新日期:2017-01-01 00:00:00
abstract::The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are invo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/793505
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), interleukin 18 (IL-18), an...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/343268
更新日期:2013-01-01 00:00:00
abstract::Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2432958
更新日期:2017-01-01 00:00:00
abstract::The observed effects after ozone exposure strongly depend on ozone concentration and exposure time. We hypothesized that depending on the O3 exposure protocol, mainly either an oxidant damage or an inflammation will determine the O3 toxicity. We compared two different ozone exposure protocols: an acute exposure (3 ppm...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359791497
更新日期:1997-01-01 00:00:00
abstract::Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/680853
更新日期:2015-01-01 00:00:00
abstract::A marked proliferation of synovial fibroblasts in joints leads to pannus formation in rheumatoid arthritis (RA). Various kinds of cytokines are produced in the pannus. The purpose of this study is to elucidate the effects of phosphodiesterase 4 (PDE4) inhibitors in a new animal model for the evaluation of pannus forma...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/58901
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY:To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD:The eff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350410001664798
更新日期:2004-02-01 00:00:00
abstract::Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors. The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice. Mice were pretreated with OA-NO...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/293474
更新日期:2015-01-01 00:00:00
abstract::Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/9086758
更新日期:2019-07-10 00:00:00
abstract::The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and is the first line of defense against chemical and/or bacterial insult. Peritonitis remains a major complication of PD and is a predominant cause ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/484167
更新日期:2012-01-01 00:00:00
abstract:AIMS:This retrospective analysis was aimed at evaluating the effectiveness of treatment of persistent diabetic macular edema with intravitreal injections of 0.7 mg dexamethasone implant Ozurdex. The study comprised three male patients (6 eyes). RESULTS:The average thickness of the retina at baseline was 632 μm, the m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/364143
更新日期:2014-01-01 00:00:00
abstract::In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/398207
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/823279
更新日期:2011-01-01 00:00:00
abstract::In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000395
更新日期:1992-01-01 00:00:00
abstract::Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a compl...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/2180417
更新日期:2016-01-01 00:00:00
abstract::Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8026494
更新日期:2016-01-01 00:00:00
abstract::Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorph...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5193723
更新日期:2020-02-19 00:00:00