A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC.

abstract：:Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF-...

journal_title：Mediators of inflammation

authors： Zarzynska JM

更新日期：2014-01-01 00:00:00

abstract：:Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal mon...

journal_title：Mediators of inflammation

authors： Platen C,Dreschers S,Wappler J,Ludwig A,Düsterhöft S,Reiss LK,Orlikowsky TW

更新日期：2019-11-03 00:00:00

abstract：:Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...

journal_title：Mediators of inflammation

authors： Kazama I

更新日期：2015-01-01 00:00:00

abstract：:The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first li...

journal_title：Mediators of inflammation

authors： Schnúr A,Hegyi P,Rousseau S,Lukacs GL,Veit G

更新日期：2016-01-01 00:00:00

abstract：Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...

journal_title：Mediators of inflammation

authors： Vitale A,Sota J,Obici L,Ricco N,Maggio MC,Cattalini M,Ruscitti P,Caso F,Manna R,Viapiana O,Caggiano V,Emmi G,Insalaco A,Montin D,Licciardi F,Soriano A,Dagna L,Salvarani C,Lamacchia V,Hernández-Rodríguez J,Giacomel

更新日期：2020-05-27 00:00:00

abstract：:Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calciu...

journal_title：Mediators of inflammation

authors： Khaleel A,Wu MS,Wong HS,Hsu YW,Chou YH,Chen HY

更新日期：2015-01-01 00:00:00

abstract：:Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensu...

journal_title：Mediators of inflammation

authors： Wang Y,Gu Y,Huang F,Liu D,Zhang Z,Zhou N,Liang J,Lu C,Yuan D,Hei Z

更新日期：2018-06-20 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...

journal_title：Mediators of inflammation

authors： Cerezo LA,Kuklová M,Hulejová H,Vernerová Z,Kaspříková N,Veigl D,Pavelka K,Vencovský J,Šenolt L

更新日期：2015-01-01 00:00:00

abstract：:There is much evidence that degradation of the extracellular matrix is essential for the development of cholesteatomas and that this is induced by activation of matrix metalloproteinases (MMPs). Vitamin D3 (VD3) has several well-recognised biological activities, including suppression of MMP production. The present stu...

journal_title：Mediators of inflammation

authors： Kobayashi H,Asano K,Kanai K,Suzaki H

更新日期：2005-08-31 00:00:00

abstract：Background:Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced...

journal_title：Mediators of inflammation

authors： Chang B,Li B,Sun Y,Teng G,Huang A,Li J,Zou Z

更新日期：2017-01-01 00:00:00

abstract：:Osteoarthritis (OA) belongs to a group of degenerative diseases. Synovial inflammation, cartilage abrasion, and subchondral sclerosis are characteristics of OA. Researchers do not fully understand the exact etiology of OA. However, matrix metalloproteinases (MMPs), which are responsible for cartilage matrix degradatio...

journal_title：Mediators of inflammation

authors： Chen YT,Hou CH,Hou SM,Liu JF

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...

journal_title：Mediators of inflammation

authors： Gong Y,Lin Y,Zhao N,He X,Lu A,Wei W,Jiang M

更新日期：2016-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...

journal_title：Mediators of inflammation

authors： Bolton C,Paul C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and s...

journal_title：Mediators of inflammation

authors： Shen M,Lu J,Dai W,Wang F,Xu L,Chen K,He L,Cheng P,Zhang Y,Wang C,Wu D,Yang J,Zhu R,Zhang H,Zhou Y,Guo C

更新日期：2013-01-01 00:00:00

abstract：:This study tested the hypothesis that shock wave therapy (SW) enhances mitochondrial uptake into the lung epithelial and parenchymal cells to attenuate lung injury from acute respiratory distress syndrome (ARDS). ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed applicat...

journal_title：Mediators of inflammation

authors： Lin KC,Wallace CG,Yin TC,Sung PH,Chen KH,Lu HI,Chai HT,Chen CH,Chen YL,Li YC,Shao PL,Lee MS,Sheu JJ,Yip HK

更新日期：2018-10-21 00:00:00

abstract：:Type 2 Diabetes Mellitus (T2DM) is well known to include an inflammatory component that has been considered to be related to diabetic complications. Diabetic nephropathy (DN) is one of the significant complications as it constitutes the most frequent cause of end-stage renal disease. Tumor Necrosis Factor-α (TNF-α) is...

journal_title：Mediators of inflammation

authors： Emara M,El-Edel R,Fathy WM,Aboelkhair NT,Watany MM,Abou-Elela DH

更新日期：2020-07-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

journal_title：Mediators of inflammation

authors： Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

更新日期：2011-01-01 00:00:00

abstract：Objective:Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods:Rat RI/RI models were constructed by surgical ope...

journal_title：Mediators of inflammation

authors： Chen F,Hu Y,Xie Y,Zhao Z,Ma L,Li Z,Tan W

更新日期：2020-11-24 00:00:00

abstract：:The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intrape...

journal_title：Mediators of inflammation

authors： Ruggiero V,D'Urso CM,Albertoni C,Campo S,Foresta P,Martelli EA

更新日期：1993-01-01 00:00:00

abstract：:Microparticles (MPs) are induced during apoptosis, cell activation, and even "spontaneous" release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs de...

journal_title：Mediators of inflammation

authors： Burbano C,Rojas M,Vásquez G,Castaño D

更新日期：2015-01-01 00:00:00

abstract：:Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 c...

journal_title：Mediators of inflammation

authors： Bystrom J,Taher TE,Muhyaddin MS,Clanchy FI,Mangat P,Jawad AS,Williams RO,Mageed RA

更新日期：2015-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), may be a pathomechanis...

journal_title：Mediators of inflammation

authors： Nokhbehsaim M,Eick S,Nogueira AV,Hoffmann P,Herms S,Fröhlich H,Jepsen S,Jäger A,Cirelli JA,Deschner J

更新日期：2013-01-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

journal_title：Mediators of inflammation

authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

更新日期：2016-01-01 00:00:00

abstract：:The role of eosinophils in inflammation and their mode of activation is not well understood. Eosinophil accumulation and subsequent expression of cytokines at the site of inflammation may play a role in exacerbation of inflammatory responses. In the present study, we have examined the role of TNF-alpha in eosinophil a...

journal_title：Mediators of inflammation

authors： Goldstein LA,Strieter RM,Evanoff HL,Kunkel SL,Lukacs NW

更新日期：1996-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was e...

journal_title：Mediators of inflammation

authors： Tang X,Liu H,Yang S,Li Z,Zhong J,Fang R

更新日期：2016-01-01 00:00:00

abstract：:Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...

journal_title：Mediators of inflammation

authors： Petricevich VL

更新日期：2010-01-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological inflammation, and coexistence with primary sclerosing cholangitis (PSC). Several molecular pathway...

journal_title：Mediators of inflammation

authors： Luo C,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote...

journal_title：Mediators of inflammation

authors： Mc Gee MM

更新日期：2015-01-01 00:00:00

abstract：:To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and...

journal_title：Mediators of inflammation

authors： Mascarenhas-Melo F,Sereno J,Teixeira-Lemos E,Marado D,Palavra F,Pinto R,Rocha-Pereira P,Teixeira F,Reis F

更新日期：2013-01-01 00:00:00

abstract：:We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...

journal_title：Mediators of inflammation

authors： Cho CW,Ahn S,Lim TG,Hong HD,Rhee YK,Yang DC,Jang M

更新日期：2017-01-01 00:00:00